Sreenivas Vishnubhatla

Cost‐Effectiveness of Early Empirical Antibiotic Cessation in Pediatric High‐Risk Febrile Neutropenia

Rupak Kumar Giri, Manraj Singh, Santhosh Kumar Kn, Archana Sasi et autres

PURPOSE: for children with high-risk febrile neutropenia (FN). In this prospective trial-based economic evaluation, we aimed to estimate the healthcare resource utilization and cost-effectiveness of early discontinuation of EAT versus continuation of EAT in children with high-risk FN in India. PATIENTS AND …

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MAP Detection: Identifying a Pathogenic Driver Rather Than a Diagnostic Marker

Sudheer K. Vuyyuru, Sreenivas Vishnubhatla, Vineet Ahuja

To the Editor—We thank the author [1] for their thoughtful, balanced, and constructive commentary on our multicenter study [2] evaluating Mycobacterium avium subspecies paratuberculosis (MAP) across Crohn disease (CD), intestinal tuberculosis (ITB), and control populations in a tuberculosis-endemic setting. We appreciate their …

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Intravenous Fosaprepitant Versus Oral Aprepitant for Children Receiving Highly Emetogenic Chemotherapy: An Investigator‐Initiated Randomized, Open‐Label, Non‐Inferiority Trial

Azgar Abdul Rasheed, Shuvadeep Ganguly, Manraj Singh, Santhosh E. Kumar et autres

BACKGROUND: Fosaprepitant is non-inferior to aprepitant in adults receiving highly emetogenic chemotherapy (HEC). We evaluated whether fosaprepitant is non-inferior to aprepitant in children receiving HEC. METHODS: In this open-label, non-inferiority trial, children aged 5-18 years, receiving their first cycle of HEC, were …

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Prevention of Neural Tube Defects in India

Aparna Sharma, Ravindra Vora, Hemonta Kr. Dutta, Santosh Karmarkar et autres

This White Paper contains details of the state-of-the-art knowledge on several issues related to the "NAMS Task Force Annals of the National Academy of Medical Sciences (India) • Article in Press • 4 METHODOLOGYThe National Academy of Medical Sciences (NAMS), recommended this …

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Association of Mycobacterium avium paratuberculosis With Crohn's Disease: A Large Multicenter Study From a Tuberculosis-Endemic Region

Sudheer K. Vuyyuru, Urvashi B. Singh, P. Ananda Selva Das, Shiv K. Basant et autres

BACKGROUND: The causal relationship between Crohn's disease (CD) and Mycobacterium avium subspecies paratuberculosis (MAP) remains controversial. METHODS: This multicenter observational study, conducted across 7 tertiary care centers in India, enrolled newly diagnosed, treatment-naive patients with CD as cases and treatment-naive patients with …

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Prevalence of Chlamydia trachomatis, Ureaplasma spp., Mycoplasma hominis and Mycoplasma genitalium in patients with sterile pyuria

Anivita Aggarwal, Debasish Biswal, Jyoti Rawre, Naval K. Vikram et autres

INTRODUCTION: Sterile pyuria poses a diagnostic challenge due to varied aetiologies. Atypical pathogens including Chlamydia trachomatis and genital mycoplasmas are considered etiological agents but are under-reported, especially in resource-limited settings. This study determined the prevalence of these atypical pathogens in sterile pyuria …

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Early stoppage of empirical antibiotic therapy in paediatric acute leukaemia with high-risk febrile neutropenia: a randomized, open-label, phase 3, non-inferiority trial

Santosh Chellapuram, Manraj Singh, Rupak Kumar Giri, Deepam Pushpam et autres

Background: Empirical antibiotic therapy (EAT) is commonly continued until recovery of neutrophil counts in paediatric acute leukaemia with high-risk febrile neutropenia. This study assessed whether early discontinuation of EAT was non-inferior to the continuation of EAT until absolute neutrophil count (ANC) ≥500/μL …

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Response to Weekly Oral Vitamin D Supplementation in Children Living with Obesity versus those with Normal BMI

Kanhaiya Lal, Shikha Sharma, Medha Mittal, Rajesh Khadgawat et autres

Abstract Introduction: Individuals living with obesity are prone to vitamin D deficiency. On supplementing vitamin D, lower serum 25(OH)D levels may be achieved in them. The present study aimed to compare the change in serum 25(OH)D after supplementation with vitamin D in …

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A randomised trial to assess the efficacy of add on therapy with aspirin or clopidogrel to the standard medical therapy alone in patients with tubercular meningitis: ACT TBM

Ritu Shree, Manish Modi, Abhishek Anand, Ajay Garg et autres

Background: Benefit of antiplatelet therapy for stroke prevention or treatment among patients of Tubercular meningitis (TBM) is uncertain. We hypothesised that add-on therapy with aspirin or clopidogrel to standard treatment will be safe and effective in reducing clinical stroke and/or cerebral infarction …

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Superparamagnetic Iron Oxide Nanoparticle Implantation and Magnetic Field Exposure Modulate Bone Microarchitecture Following Spinal Cord Injury in Adult Male Rats

Arpita Chakraborty, Konica Porwal, Srishty Raman, Subhash Chandra Yadav et autres

Background: Osteoporosis is one of the detrimental effects of spinal cord injury (SCI), leading to bone loss. It has already been established that superparamagnetic nanoparticles when exposed to an external magnetic field (MF) show strong magnetisation and promote locomotor recovery. Purpose: The …

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Efficacy of exercises in early-stage Parkinson’s disease (PARK-EASE trial): single-blind, randomised, controlled trial

Raktim Swarnakar, Sanjay Wadhwa, Srikumar Venkataraman, Vinay Goyal et autres

Objectives: To assess the efficacy of exercises in early-stage Parkinson's disease (PD). Design: Single-blind, randomised controlled trial. Setting: Tertiary rehabilitation care centre. Participants: Forty individuals (≥18 years, either gender) with newly diagnosed PD (Hoehn and Yahr stage ≤2) on a stable dose …

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Early Chemotherapeutic Response Evaluation In Ewing Sarcoma Using Diffusion Weighted MRI

Esha Baidya Kayal, Jayendra Tiru Alampally, Raju Sharma, Sameer Bakhshi et autres

The objective of this prospective study was to assess the role of diffusion weighted MRI for early evaluation of chemotherapy response in patients with Ewing sarcoma with RECIST 1.1 criteria correlation. Absolute apparent diffusion coefficient (ADC), normalized ADC (nADC) and tumor diameter …