Andrew Phillips

A highly virulent variant of HIV-1 circulating in the Netherlands

Chris Wymant, Daniela Bezemer, François Blanquart, Luca Ferretti et autres

increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical …

gb, nl, fr, se, de, ch, us, fi (code pays fourni par la source)

Determining the Origins of Human Immunodeficiency Virus Type 1 Drug-resistant Minority Variants in People Who Are Recently Infected Using Phylogenetic Reconstruction

Jean L. Mbisa, Peter Kirwan, Anna Tostevin, Juan Ledesma et autres

BACKGROUND: Drug-resistant minority variants (DRMinVs) detected in patients who recently acquired human immunodeficiency virus type 1 (HIV-1) can be transmitted, generated de novo through virus replication, or technical errors. The first form is likely to persist and result in treatment failure, while …

gb, Kenya (code pays fourni par la source)

CD4 T cell decline following HIV seroconversion in individuals with and without CXCR4-tropic virus

J Ghosn, Tatiana Bayan, Karolin Meixenberger, Laurent Tran et autres

Background: The natural clinical and immunological courses following HIV seroconversion with CXCR4-tropic or dual-mixed (X4/DM) viruses are controversial. We compared spontaneous immunological outcome in patients harbouring an X4/DM virus at the time of seroconversion with those harbouring a CCR5-tropic (R5) virus. Methods: …

fr, de, it, at, es, gb (code pays fourni par la source)

A Phylogenetic Analysis of Human Immunodeficiency Virus Type 1 Sequences in Kiev: Findings Among Key Populations

Esther Fearnhill, Annabelle Gourlay, Ruslan Malyuta, Ruth Simmons et autres

Background: The human immunodeficiency virus (HIV) epidemic in Ukraine has been driven by a rapid rise among people who inject drugs, but recent studies have shown an increase through sexual transmission. Methods: Protease and reverse transcriptase sequences from 876 new HIV diagnoses …

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Plasma HIV‐1 tropism and risk of short‐term clinical progression to AIDS or death

Maria Casadellà Fontdevila, Alessandro Cozzi‐Lepri, Andrew Phillips, Marc Noguera-Julián et autres

INTRODUCTION: It is uncertain if plasma HIV-1 tropism is an independent predictor of short-term risk of clinical progression / death, in addition to the CD4 count and HIV RNA level. We conducted a nested case-control study within EuroSIDA to assess this question …

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The Contribution of Viral Genotype to Plasma Viral Set-Point in HIV Infection

Emma B. Hodcroft, Jarrod D. Hadfield, Esther Fearnhill, Andrew Phillips et autres

Disease progression in HIV-infected individuals varies greatly, and while the environmental and host factors influencing this variation have been widely investigated, the viral contribution to variation in set-point viral load, a predictor of disease progression, is less clear. Previous studies, using transmission-pairs …

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Symptomatic Illness and Low CD4 Cell Count at HIV Seroconversion as Markers of Severe Primary HIV Infection

Sara Lodi, Martin Fisher, Andrew Phillips, Andrea De Luca et autres

BACKGROUND: The risk/benefit of initiating ART in primary HIV infection (PHI) is unclear. The benefits are more likely to outweigh the risks in patients with severe PHI. An accepted definition of severe PHI is, however, lacking. METHODS: CASCADE patients with HIV test …

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Prevention of HIV-1 Infection with Antiretroviral Therapy

Alison Rodger, Andrew Phillips, Jens Lundgren

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Immunologic marker paths for seroconversion: single determinations of immunoglobulin A and [beta]2-microglobulin are not adequate to estimate time of HIV infection: multicohort analysis project workshop, part 2

Gary S. Bird, R. Frank Cook, Daniela DeAngelis, Vernon T. Farewell et autres

Immunologic markers of AIDS progression - consistency across 5 HIV-infected cohorts: multicohort analysis project workshop, part 1

Geoffrey L. Bird, Ryan Cook, Daniela DeAngelis, Vernon T. Farewell et autres