Jiayuan Wu

The microbiome-mitochondria axis: the context-dependent role of urolithin A in aging and cancer via mitophagy

Jiayuan Wu, Xinxin Ye, Wei Hua, Yuyang Yao et autres

cn, us (code pays fourni par la source)

WTAP Histone Lactylation Drives the YTHDF1/ALOX15 Axis to Regulate Ferroptosis in Myocardial Ischemia–Reperfusion Injury

Wei Liu, Yuqin Wang, Jiayuan Wu, Caihong He et autres

ABSTRACT Lactate, a metabolic byproduct of glycolysis, accumulates during myocardial infarction and ischemia/reperfusion (I/R) injury, acting as both a metabolic stress marker and a signaling molecule that influences inflammation and cell fate. Lactate can induce histone lysine lactylation (Kla), a novel post‐translational …

cn (code pays fourni par la source)

Unlocking efficient galactose utilization in Chlorella pyrenoidosa through adaptive laboratory evolution: A sustainable strategy for red seaweed-based microalgal cultivation

Shi‐Kai Wang, Shengjie Wu, Zhifeng Li, Jiayuan Wu

cn (code pays fourni par la source)

DNA methyltransferase 1-mediated methylation of midkine regulate myocardial ischemia-reperfusion injury via the Notch2/Hes1 axis

Wei Liu, Yuqin Wang, Jiayuan Wu, Caihong He et autres

myocardial ischemia-reperfusion injury (MI/RI) threatens people's lives. Midkine (MDK) has a protective effect against MI/RI. DNA methyltransferase 1 (DNMT1) is closely associated with MI/RI. Mouse cardiomyocytes were isolated to establish a model of myocardial ischemia-reperfusion. Subsequently, the viability, apoptosis, and inflammatory factors …

cn (code pays fourni par la source)

Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Kanyin Liane Ong, Damian Francesco Santomauro, A Bhoomadevi, Mohammad Amin Aalipour et autres

BACKGROUND: For more than three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has provided a framework to quantify health loss due to diseases, injuries, and associated risk factors. This paper presents GBD 2023 findings on disease and …

us, au, ae, ir, jo, Nigéria, gb, it, Égypte, sa, Algérie, iq, in, kz, Éthiopie, fi, mx, bd, Ghana, se, pl, br, jp, qa, ps, np, ag, de, Afrique du Sud, bg, id (code pays fourni par la source)

Erk1/2-Nf-Κb Crosstalk Mediates Mechanoregulation Of Dpscs

Yuting Sun, Jian Zhang, Jiayuan Wu

To elucidate how dynamic hydrostatic pressure regulates dental pulp stem cells(DPSCs) behavior and the response mechanisms of ERK1/2 and NF-κB signaling pathways. This project used a cell pressure loading device to simulate occlusal trauma.DPSCs(P3-P5) obtained via the method of tissue block combined …

cn (code pays fourni par la source)

Abscisic acid enhances DNA damage response through the nuclear shuttling of clathrin light chain 2 in plant cells

Jieming Jiang, Qiuhua Zhu, Yang Li, Jiayuan Wu et autres

DNA damage arises from various environmental stresses, and ABA is well known for its roles in plant stress resistance. However, its function in plant DNA damage tolerance remains unclear. In this study, we showed that ABA supplementation significantly enhances plant tolerance to …

cn (code pays fourni par la source)

Lipid-Lowering Potential of Almond Hulls (Quercetin, Baicalein, and Kaempferol): Insights from Network Pharmacology and Molecular Dynamics

Qiming Miao, Lu Sun, Jiayuan Wu, Xinyue Zhu et autres

The advancement of modern lifestyles has precipitated excessive consumption of energy-dense foods, driving the escalating global burden of lipid metabolism dysregulation-related pathologies—including obesity, type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and cardiovascular disorders—which collectively pose a formidable challenge to …

cn, us (code pays fourni par la source)

Expert consensus on management of instrument separation in root canal therapy

Yi Fan, Yuan Gao, Xiangzhu Wang, Bing Fan et autres

Instrument separation is a critical complication during root canal therapy, impacting treatment success and long-term tooth preservation. The etiology of instrument separation is multifactorial, involving the intricate anatomy of the root canal system, instrument-related factors, and instrumentation techniques. Instrument separation can hinder …

cn, us (code pays fourni par la source)

Expert consensus on intentional tooth replantation

Zhengmei Lin, Dingming Huang, Shuheng Huang, Zhi Chen et autres

Intentional tooth replantation (ITR) is an advanced treatment modality and the procedure of last resort for preserving teeth with inaccessible endodontic or resorptive lesions. ITR is defined as the deliberate extraction of a tooth; evaluation of the root surface, endodontic manipulation, and …

cn, hk, us (code pays fourni par la source)

A synthetic biology approach for identifying de‐SUMOylation enzymes of substrates

Junwen Huang, Jiayuan Wu, Mi Zhou, Siyi Luo et autres

A synthetic biology approach using a robust reconstitution system in Escherichia coli enables the identification of plant ubiquitin-like proteases responsible for removing the small ubiquitin-like modifier (SUMO) post-translational modifications from specific protein substrates.

cn (code pays fourni par la source)

E3 ubiquitin ligase Smurf1 promotes cardiomyocyte pyroptosis by mediating ubiquitin-dependent degradation of TRIB2 in a rat model of heart failure

Xin Cai, Shuhan Duan, Jinhua Shen, Jiayuan Wu et autres

OBJECTIVE: Heart failure (HF) causes structural and functional changes in the heart, with the pyroptosis-mediated inflammatory response as the core link in HF pathogenesis. E3 ubiquitin ligases participate in cardiovascular disease progression. Here, we explored the underlying molecular mechanisms of E3 ubiquitin …

cn (code pays fourni par la source)