M S Knapp

Implementing National Institute for Health and Care (NICE) Guidelines in Long-term Care in England and Wales: “Is it worth it?”- A theory-informed economic evaluation

Annette Bauer, Joaquín Mayorga Camus, Ties Hoomans, Erica Breuer et autres

Background: Providing affordable, good-quality long-term care is a pertinent challenge. Little is known about how councils implement good practice guidelines, resources required and the benefits of implementation. Objective: To assess the processes, cost and consequences of implementing guidelines by the National Institute …

Implementing National Institute for Health and Care (NICE) Guidelines in Long-term Care in England and Wales: “Is it worth it?”- A theory-informed economic evaluation

Helen Weatherly, Ties Hoomans, Sarah Jasim, Juliette Malley et autres

Background: Providing affordable, good-quality long-term care is a pertinent challenge. Little is known about how councils implement good practice guidelines, resources required and the benefits of implementation. Objective: To assess the processes, cost and consequences of implementing guidelines by the National Institute …

Chronobiology and the Kidney

M S Knapp

The kidney plays a critical role in maintaining a stable internal environment by balancing output and intake, circadian variations in the contents of intracellular and extracellular fluids, the levels of some pharmaceuticals and total body water volume. Variations in the quantities of …

Clock Proteins and Circadian Rhythms in Immunity

Annie M. Curtis, M S Knapp

The circadian clock influences many, if not all, aspects of immunity. Variations across daily time scales have been observed in immune cell migration, differentiation and effector function, including cytokine/chemokine production, phagocytosis, antigen presentation, lymphocyte proliferation and the allergic response. Circadian clock disruption …

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Rhythmicity In Immunity And In Factors Influencing Immune Responses

M S Knapp

Rhythmic changes often approximate to sinusoidal, and analysis by the least squares method of analysis, sometimes referred to as the Cosinor method in chronobiological literature, are often adequate to establish rhythmicity, but do not exclude it when rhythmic change is non-sinusoidal or …

Time of administration of treatment for hypertension in renal patients

M S Knapp

Wang et al.1 make a valuable contribution to an aspect of blood pressure management often ignored. In 1961, in blood pressure studies over 24 h, we observed blood pressure did not fall at night in patients with malignant (accelerated) hypertension who had …

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Computing in Medical Chronobiology; practical aspects of data collection, analysis and instrumentation

M S Knapp, Kerry Gordon

Monitoring change in renal function

M S Knapp

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Lymphocytes are rhythmic: is this important?

M S Knapp, R Pownall

The epidemiology of tuberculosis in physicians.

Saline depletion, pre-renal failure and acute renal failure

M S Knapp

Mathematical and statistical aids to evaluate data from renal patients

M S Knapp, Martin S. Knapp, A. F. M. Smith, Ian M. Trimble et autres

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Introduction; Computing, mathematics, and the nephrologist

M S Knapp