Olumide Adeleye

Circulating proteins to predict COVID-19 severity

Chen‐Yang Su, Sirui Zhou, Edgar Gonzalez‐Kozlova, Guillaume Butler‐Laporte et autres

Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully understood. To approach this problem, we measured 4701 circulating human protein abundances in two independent cohorts totaling 986 individuals. We then trained prediction models including protein abundances and clinical …

ca, us, jp, gb, de, ch (code pays fourni par la source)

Correction: The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals

Guillaume Butler‐Laporte, Edgar Gonzalez‐Kozlova, Chen‐Yang Su, Sirui Zhou et autres

ca, us, jp, gb, de (code pays fourni par la source)

The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals

Guillaume Butler‐Laporte, Edgar Gonzalez‐Kozlova, Chen‐Yang Su, Sirui Zhou et autres

INTRODUCTION: Severe COVID-19 leads to important changes in circulating immune-related proteins. To date it has been difficult to understand their temporal relationship and identify cytokines that are drivers of severe COVID-19 outcomes and underlie differences in outcomes between sexes. Here, we measured …

ca, us, jp, gb, de (code pays fourni par la source)

A first update on mapping the human genetic architecture of COVID-19

COVID-19 Host Genetics Initiative, COVID-19 Host Genetics Initiative, Leadership, Gita A. Pathak et autres

The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative 1 . Here we present …

us, fi, pl, be, ca, jp (code pays fourni par la source)

Whole-genome sequencing reveals host factors underlying critical COVID-19

Athanasios Kousathanas, Erola Pairo‐Castineira, Konrad Rawlik, A. Stuckey et autres

after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically …

gb, au, cn, ca, ie, us, hk, Ouganda, br (code pays fourni par la source)

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

Matteo D’Antonio, Jennifer Nguyen, Timothy D. Arthur, Hiroko Matsui et autres

Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an …

us (code pays fourni par la source)

Circulating proteins to predict adverse COVID-19 outcomes

Chen‐Yang Su, Sirui Zhou, Edgar Gonzalez‐Kozlova, Guillaume Butler‐Laporte et autres

Abstract Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully understood. To approach this problem, we measured 4,701 circulating human protein abundances in two independent cohorts totaling 986 individuals. We then trained prediction models including protein abundances and …

ca, us, jp, gb, de (code pays fourni par la source)

Mapping the human genetic architecture of COVID-19

Mari Niemi, Juha Karjalainen, Rachel G. Liao, Benjamin M. Neale et autres

Abstract The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may …

fi, us, es, de, it, gb, nl, ca, kr, jp, ae, fr, au, pl, in, be, qa, dk, cl, pr, mx (code pays fourni par la source)

Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study

Guillaume Butler‐Laporte, Tomoko Nakanishi, Vincent Mooser, David Morrison et autres

BACKGROUND: Increased vitamin D levels, as reflected by 25-hydroxy vitamin D (25OHD) measurements, have been proposed to protect against COVID-19 based on in vitro, observational, and ecological studies. However, vitamin D levels are associated with many confounding variables, and thus associations described …

ca, jp, il, it, gb (code pays fourni par la source)

A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity

Sirui Zhou, Guillaume Butler‐Laporte, Tomoko Nakanishi, David Morrison et autres

ca, jp, gb, us, se, de (code pays fourni par la source)

A Neanderthal OAS1 isoform Protects Against COVID-19 Susceptibility and Severity: Results from Mendelian Randomization and Case-Control Studies

Sirui Zhou, Guillaume Butler‐Laporte, Tomoko Nakanishi, David Morrison et autres

Abstract Proteins detectable in peripheral blood may influence COVID-19 susceptibility or severity. However, understanding which circulating proteins are etiologically involved is difficult because their levels may be influenced by COVID-19 itself and are also subject to confounding factors. To identify circulating proteins …

ca, jp, gb, us, se, de (code pays fourni par la source)

Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study

Guillaume Butler‐Laporte, Tomoko Nakanishi, Vincent Mooser, David Morrison et autres

Abstract Background Increased vitamin D levels, as reflected by 25OHD measurements, have been proposed to protect against COVID-19 disease based on in-vitro , observational, and ecological studies. However, vitamin D levels are associated with many confounding variables and thus associations described to …

ca, jp, il, it, gb (code pays fourni par la source)