Accès ouvert
2023
article
OpenAlex
Sofia Morfopoulou, Sarah Buddle, Oscar Enrique Torres Montaguth, Laura Atkinson et autres
. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, …
gb, de, fr, sa
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Accès ouvert
2023
article
OpenAlex
Antonia Ho, Richard Orton, Rachel Tayler, Patawee Asamaphan et autres
An outbreak of acute hepatitis of unknown aetiology in children was reported in Scotland1 in April 2022 and has now been identified in 35 countries2. Several recent studies have suggested an association with human adenovirus with this outbreak, a virus not commonly …
gb, us
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Accès ouvert
2022
article
OpenAlex
Elen Vink, Christopher Davis, Alasdair Maclean, David J. Pascall et autres
Background: We conducted this study to assess the prevalence of viral coinfection in a well characterized cohort of hospitalized coronavirus disease 2019 (COVID-19) patients and to investigate the impact of coinfection on disease severity. Methods: Multiplex real-time polymerase chain reaction testing for …
gb, us
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Accès ouvert
2020
article
OpenAlex
Arran Turnbull, Çiğdem Selli, Carlos Martínez-Pérez, Anu Fernando et autres
BACKGROUND: High-throughput transcriptomics has matured into a very well established and widely utilised research tool over the last two decades. Clinical datasets generated on a range of different platforms continue to be deposited in public repositories provide an ever-growing, valuable resource for …
gb, tr, us
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Accès ouvert
2015
article
OpenAlex
John P. Thomson, Angie Fawkes, Raffaele Ottaviano, Jennifer M. Hunter et autres
Modification of DNA resulting in 5-methylcytosine (5 mC) or 5-hydroxymethylcytosine (5hmC) has been shown to influence the local chromatin environment and affect transcription. Although recent advances in next generation sequencing technology allow researchers to map epigenetic modifications across the genome, such experiments …
gb
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1985
article
OpenAlex
Audrey Coutts, Ken Grigor, James W. Fowler
Sixty-five patients had a cystectomy for a solitary bladder tumour (28) or multifocal lesions (37). The histological extent of the disease within the bladder was correlated with mucosal abnormalities within the urethra. The presence of multifocal or solitary bladder disease was not …
gb
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