Lin Xiao

Harnessing conductive hydrogels for spinal cord injury repair: From bioelectrical design to neural circuit reconstruction

Dong Guo, Lin Xiao, Ke Xu, Hui Li et autres

Spinal cord injury (SCI) causes permanent neurological impairment as it disrupts both tissue structure and endogenous bioelectrical signaling. While traditional biomaterial scaffolds offer structural support, they often fall short of actively modulating the local electrophysiological environment needed for neural regeneration. In this …

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Coaxially electrospun silk fibroin scaffold incorporating kartogenin via β-cyclodextrin for rotator cuff repair

Q. W. Ping, Z Wang, Tao Yang, Xiaoxuan Wu et autres

Rotator cuff tears (RCT) constitute a prevalent and clinically challenging musculoskeletal pathology. Medications, such as anti-inflammatory drugs, only alleviate symptoms without addressing the underlying cause, and their delivery efficiency is relatively low. Surgical interventions often fail to restore the native gradient structure …

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In Situ Reinforcement of Polysilazane in the Preservation of Excavated Water-Bearing Decayed Ivory Based on Biointerface Water-Triggered Reactions

Ting Wang, Yifan Zhang, Runge Liu, Shilin Xiang et autres

The excavated ivory from the Sanxingdui archeological site is typically found in a water-bearing and extremely fragile state due to prolonged exposure to complex burial conditions, posing significant challenges for conservation efforts. Particularly concerning are severely decayed and water-bearing ivory specimens, whose …

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Polyrotaxanes Send Shuttling Signals

Xinlin Jiang, Yuting Tan, Yi‐Chen Lin, Wenjie Fu et autres

Mimicking intercellular communication by dynamically presenting signaling molecules to cells is central to understanding biological processes and building artificial life systems. However, precise replication and control of such communication at the molecular level in synthetic environments remain largely unexplored. Here, we present …

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Self-Amplifying Metal–Covalent Organic Framework for Programmable Antibacterial-Regenerative Therapy via ROS Cascades

Ya Li Hu, Lin Xiao, M.C. Zang, Jinhong Zhang et autres

Herein, we present an infection microenvironment (IME)-adaptive covalent organic framework (COF), termed Cu–B–COF, engineered through dynamic assembly of a bidentate N -substituted salicylimine-Cu complex [Cu(SALANIH-boronic acid) 2 ] and 5,10,15,20-tetrakis(2,3-dihydroxyphenyl)porphyrin. Cu–B–COF, integrating the characteristics of both metal–organic frameworks (MOFs) and COFs, could …

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Dual-Mode Colorimetric and Fluorescent Detection of Tumor Cells Based on Gold Nanoparticles-Loaded Phosphine Covalent Organic Frameworks

Bilian Li, Min Zhou, Chun Zhi Zhao, Lin Xiao et autres

Abstract Circulating tumor cells (CTCs) are important markers for cancer. The part of tumor cells that are detached from the primary tumor or metastatic tumor and enter the blood circulation is called CTCs. It is crucial to develop a rapid, accurate, and …

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Combination of surfactants and enzyme cocktails for enhancing woody biomass saccharification and bioethanol production from lab-scale to pilot-scale

Wei Qi, Qifa Feng, Wen Wang, Yu Zhang et autres

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Supplementary Tables 1-5 from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma

Lin Xiao, Klaartje Somers, Jayne E. Murray, Ruby Pandher et autres

Supplementary Tables S1-S5

Supplementary Video S3 from Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma

Lin Xiao, Klaartje Somers, Jayne E. Murray, Ruby Pandher et autres

HT10806TG_Panobinostat treatment

Combination of Surfactants and Enzyme Cocktails for Enhancing Woody Biomass Saccharification and Bioethanol Production from Lab-Scale to Pilot-Scale

Wei Qi, Qifa Feng, Wen Wang, Yu Zhang et autres

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Engineering the biomechanical microenvironment of chondrocytes towards articular cartilage tissue engineering

Weichang Xu, Jing Fei Zhu, Jiawei Hu, Lin Xiao

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Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population

Xi Wang, Lin Xiao, Zhiyuan Wang, Liqiang Zhi et autres

Abstract Osteoarthritis (OA) is one of the most popular degenerative joint diseases. The nucleolar GTP binding protein 3 (GNL3) gene encodes guanine nucleotide binding protein-like 3, which is related in cell proliferation, differentiation, and cell cycle regulation. Our study aimed to examine …

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