Hongshu Jing

IDO1 inhibition enhances CLDN18.2-CAR-T cell therapy in gastrointestinal cancers by overcoming kynurenine-mediated metabolic suppression in the tumor microenvironment

Zhaorong Wu, Hongye Wang, Zhigang Zheng, Yan Lin et autres

BACKGROUND: Chimeric antigen receptor (CAR)-T cell therapy has achieved remarkable success in hematologic malignancies but faces significant limitations in gastrointestinal tumors due to the immunosuppressive tumor microenvironment (TME). Indoleamine 2,3-dioxygenase 1 (IDO1), a key enzyme in the TME, suppresses T cell efficacy …

cn (code pays fourni par la source)

A pre-clinical model combined cryopreservation technique with precision-cut slice culture method to assess in vitro drug response of hepatocellular carcinoma

Yuan Zhang, Zhenyu Wang, Hongshu Jing, Hong-dan Zhang et autres

Background The aim of this study was to create a patient-derived slice model by combining cryopreservation technique with precision-cut slice culture method and explore its effectivity of predicting anti-cancer drug sensitivity in vitro. Methods We prepared 0.3 mm thick tissue slices by …

cn (code pays fourni par la source)

Sprayable, thermosensitive hydrogels for promoting wound healing based on hollow, porous and pH-sensitive ZnO microspheres

Wei Zhang, Hongshu Jing, Qiang Niu, Zhihua Wu et autres

A solvothermal method and the subsequent heat treatment process were developed to fabricate hollow ZnO particles with hierarchical pores on a large scale. The as-obtained hollow, porous ZnO microspheres with tunable sizes, high specific surface areas, pH sensitivity, antibacterial properties, and high …

cn (code pays fourni par la source)

Dissolving microneedles-based programmed delivery system for enhanced chemo-immunotherapy of melanoma

Yu Tian, Hongshu Jing, Quan Wang, Suxian Hu et autres

cn (code pays fourni par la source)

Recent progress in orodispersible films‐mediated therapeutic applications: A review

Yu Tian, Jiangtao Lin, Hongshu Jing, Quan Wang et autres

Abstract Orodispersible films (ODFs) as a relatively novel delivery platform have increasingly attracted enormous attention owing to their various advantages compared to conventional oral dosage forms, including fast disintegration, ease of administration without consumption of water, and rapid absorption of incorporated drug, …

cn (code pays fourni par la source)

Inhibition of atherosclerosis progression by modular micelles

Quan Wang, Yi Duan, Hongshu Jing, Zhihua Wu et autres

cn (code pays fourni par la source)

Programmed prodrug breaking the feedback regulation of P-selectin in plaque inflammation for atherosclerotic therapy

Quan Wang, Hongshu Jing, Jun Lin, Zhihua Wu et autres

cn (code pays fourni par la source)

A pre‑clinical model combining cryopreservation technique with precision‑cut slice culture method to assess the in vitro drug response of hepatocellular carcinoma

Yuan Zhang, Zhenyu Wang, Hongshu Jing, Hong‐Dan Zhang et autres

Models considering hepatocellular carcinoma (HCC) complexity cannot be accurately replicated in routine cell lines or animal models. We aimed to evaluate the practicality of tissue slice culture by combining it with a cryopreservation technique. We prepared 0.3‑mm‑thick tissue slices by a microtome …

cn (code pays fourni par la source)

cRGD Peptide-Modified Nanocarriers for Targeted Delivery of Angiogenesis Inhibitors to Attenuate Advanced Atherosclerosis

Zhaojun Li, Quan Wang, Hongshu Jing, Xianghong Luo et autres

Neovascularization in plaque is the main driving factor for the formation of vulnerable plaque. It is an effective strategy to alleviate atherosclerosis by intervening neovascularization. Herein, we constructed a cRGD peptide (cyclo(Arg–Gly–Asp– d -Phe–Cys))-modified nanodelivery systems (RNPs) for targeted delivery of an …

cn (code pays fourni par la source)

An extracorporeal bioartificial liver embedded with 3D-layered human liver progenitor-like cells relieves acute liver failure in pigs

Weijian Li, Xuejing Zhu, Tianjie Yuan, Zhenyu Wang et autres

= 0.003). The blood ammonia concentrations, as well as the biochemical and coagulation indices, were reduced in Ali-BAL-treated pigs. Ali-BAL treatment attenuated liver damage, ameliorated inflammation, and enhanced liver regeneration in the ALF porcine model and could be considered as a potential …

cn (code pays fourni par la source)

Cryopreserved biopsy tissues of rectal cancer liver metastasis for assessment of anticancer drug response in�vitro and in�vivo

Yuan Zhang, Weijian Huang, Qiu‐Rui Yang, Hong‐Dan Zhang et autres

Living tumors are of great scientific value for clinical medicine and basic research, especially for drug testing. An increasing number of drug tests fail due to the use of imperfect models. The aim of the present study was to develop a novel …

cn (code pays fourni par la source)

A DMSO-free hepatocyte maturation medium accelerates hepatic differentiation of HepaRG cells in vitro

Zhenyu Wang, Weijian Li, Qigen Li, Hongshu Jing et autres

The most essential tools for studying drug hepatotoxicity, liver diseases, and bioartificial livers have always been models that can recapitulate liver physiology in vitro. The liver progenitor cell line HepaRG represents an effective surrogate of the primary hepatocyte. However, the differentiation of …

cn (code pays fourni par la source)