Christopher M. Cannon

Single-colony resolution of CRISPR–Cas adaptation in E. coli reveals altered spacer-source bias during solid-phase growth

J. Vernon Braithwaite, Christopher M. Cannon, Ronald Chalmers, Harold T. Edwards

CRISPR-Cas systems provide adaptive immunity by integrating short DNA fragments from mobile genetic elements into host arrays. While the core biochemical mechanism of adaptation is well defined, its modulation by physiological contexts is less well understood. Here, we present a visual papillation …

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A Gap Between Willingness and Uptake: Findings From Mixed Methods Research on HIV Prevention Among Black and Latina Transgender Women.

Mannat Malik, Erin E. Cooney, Tonia Poteat, William D. Hardy et autres

BACKGROUND: Black and Latina transgender women (BLTW) face significant HIV disparities with estimated HIV prevalence up to 50% and annual incidence rates as high as 2.8 per 100 person-years. However, few studies have evaluated the acceptability and uptake of high-impact HIV prevention …

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Biopsychosocial Mechanisms Linking Gender Minority Stress to HIV Comorbidities Among Black and Latina Transgender Women (LITE Plus): Protocol for a Mixed Methods Longitudinal Study

Robert‐Paul Juster, Nicole Davis, Tonia Poteat, Keri N. Althoff et autres

BACKGROUND: Black and Latina transgender women (TW) experience a disparate burden of HIV and related comorbidities, including poor mental health and cardiovascular disease (CVD) risks. Pervasive multilevel stigma and discrimination operate as psychosocial stressors for TW living with HIV and shape health …

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Perceived HIV Acquisition Risk and Low Uptake of PrEP Among a Cohort of Transgender Women With PrEP Indication in the Eastern and Southern United States

Keri N. Althoff, Erin E. Cooney, Asa E. Radix, Jason S. Schneider et autres

INTRODUCTION: Preexposure prophylaxis (PrEP) is effective in preventing HIV among adherent users. However, PrEP uptake among transgender women is low, and current prescribing guidelines from the Centers for Disease Control and Prevention (CDC) are not specific to transgender women. Self-perceived risk of …

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PrEP initiation and discontinuation among transgender women in the United States: a longitudinal, mixed methods cohort study

Keri N. Althoff, Christopher M. Cannon, Rodrigo A. Aguayo‐Romero, Andrew J. Wawrzyniak et autres

INTRODUCTION: Transgender women in the United States experience high HIV incidence and suboptimal Pre-exposure prophylaxis (PrEP) engagement. We sought to estimate PrEP initiation and discontinuation rates and characterize PrEP discontinuation experiences among a prospective cohort of transgender women. METHODS: Using a sequential, …

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Preference for Long-Acting Injectable PrEP Compared With Daily Oral PrEP Among Transgender Women in the U.S.: Findings From a Multisite Cohort

Erin E. Cooney, Sari L. Reisner, Tonia Poteat, Asa E. Radix et autres

Introduction: Pre-exposure prophylaxis (PrEP) use among transgender women in the U.S. has not reached levels optimal to change the trajectory of the HIV epidemic owing to multilevel barriers. Long-acting injectable PrEP received Food and Drug Administration approval in 2021 and may potentially …

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Preference for Long-Acting HIV Prevention Methods Among Transgender Women Vulnerable to HIV in Eastern and Southern United States: Findings from the LITE Study

Erin E. Cooney, Megan M. Stevenson, Rodrigo A. Aguayo‐Romero, G. Guerra Valera et autres

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Hormones, Stress, and Heart Disease in Transgender Women with HIV in LITE Plus

Tonia Poteat, Molly R Ehrig, Hedyeh Ahmadi, Mannat Malik et autres

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Site-Based and Digital Cohort Participation Among Transgender Women in the Eastern and Southern United States: Findings From the LITE Study

Sari L. Reisner, Elizabeth Humes, Megan M. Stevenson, Erin E. Cooney et autres

BACKGROUND: Transgender women (TW) are highly burdened by HIV. There is increasing interest in digital (ie, through Internet-based interfaces) HIV research; yet few studies have assessed potential biases of digital compared with site-based data collection. This study examined differences in characteristics between …

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Brief Report: Interest in Long-acting Injectable PrEP Among Transgender Women in Eastern and Southern United States

Erin E. Cooney, Sari L. Reisner, Tonia Poteat, Keri N. Althoff et autres

BACKGROUND: Among communities with elevated HIV burden, increased uptake of PrEP, including long-acting injectable (LAI) PrEP, could lower HIV incidence. Lack of data on LAI PrEP interest among transgender women in the United States has limited scientific understanding of the potential impact …

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Racial/ethnic differences in the association between transgender-related U.S. state policies and self-rated health of transgender women

Wesley M. King, Kristi E. Gamarel, Nancy L. Fleischer, Asa E. Radix et autres

BACKGROUND: Policy protections for transgender adults in the United States are consistently associated with positive health outcomes. However, studies over-represent non-Latinx White transgender people and obscure variation in policies' intended goals. This study examined racial differences in the relationship between transgender-related policies …

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Access to healthcare among transgender women living with and without HIV in the United States: associations with gender minority stress and resilience factors

Talia A. Loeb, Sarah McIvor Murray, Erin E. Cooney, Tonia Poteat et autres

BACKGROUND: Transgender women (TW) experience significant inequities in healthcare access and health disparities compared to cisgender populations. Access to non-transition related healthcare is understudied among TW. We aimed to assess the association between access to care and gender minority stress and resilience …

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