Signe Nielsen

Identification of novel plasma proteomic biomarkers of Dupuytren disease

Blake H. Hummer, Paola Sebastiani, Anastasia Leshchyk, Anastasia Gurinovich et autres

Dupuytren Disease (DD) is a chronic progressive disease that can cause disabling hand deformities. The most common treatments have either high complication rates or high early recurrence rates. Dupuytren lacks a staging biomarker profile to inform the development of preventive therapeutics to …

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From 1D Independence to 3D Coherence: Geostatistical Simulation of Probabilistic TEM Inversions

Signe Nielsen, Rasmus Bødker Madsen, Anders Damsgaard, Thomas Mejer Hansen et autres

Groundwater modelling relies on three-dimensional (3D) geological models as structural input to predict subsurface processes such as groundwater flow and contaminant transport. However, model uncertainty in the geological domain, originating from sparse data coverage and the inherent non-uniqueness of geophysical inverse problems, …

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CORRELATIONS BETWEEN BIOCHEMICAL MARKERS OF CARTILAGE TURNOVER, PAIN CATEGORIES, AND BASELINE CHARACTERISTICS IN A CLINICAL OSTEOARTHRITIS STUDY, EFEX-OA-02

C.P. Miller, Jonathan Jetsmark Bjerre-Bastos, Solveig Skovlund Groen, Signe Nielsen et autres

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Higher Collagen VI Formation Is Associated With All-Cause Mortality in Patients With Type 2 Diabetes and Microalbuminuria

Daniel Guldager Kring Rasmussen, Tine W. Hansen, Bernt Johan von Scholten, Signe Nielsen et autres

OBJECTIVE Type 2 diabetes is a common risk factor for the development of chronic kidney disease (CKD). Enhanced de novo collagen type VI (COL VI) formation has been associated with renal fibrosis and CKD. We investigated the hypothesis that PRO-C6, a product …

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SO014A NOVEL URINARY BIOMARKER OF TYPE VI COLLAGEN FORMATION AND ENDOTROPHIN IS ASSOCIATED WITH LOSS OF KIDNEY FUNCTION IN PATIENTS WITH DIABETIC NEPHROPATHY

Federica Genovese, Daniel Bech Rasmussen, Signe Nielsen, Joseph V. Haas et autres

INTRODUCTION AND AIMS: Diabetic nephropathy (DN) is the leading cause of CKD in the Western world. Around 50 percent of patients who have had diabetes for more than 20 years develop CKD. Glomerulosclerosis and tubulointerstitial fibrosis are histological features as DN progresses …

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Type XIX Collagen

Signe Nielsen, M.A. Karsdal ​

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FP221SERUM AND URINE MARKERS OF COLLAGEN DEGRADATION REFLECT RENAL FIBROSIS IN EXPERIMENTAL KIDNEY DISEASES

Marios Papasotiriou, Federica Genovese, Barbara M. Klinkhammer, Uta Kunter et autres

Introduction and Aims: Currently, renal biopsy is the only specific modality for diagnosis and assessment of renal fibrosis, the common pathway and a robust predictor of progressive kidney diseases. Here we explored the diagnostic potential of specific degradation and formation fragments of …

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Unsaturated zone leaching models for assessing risk to groundwater of contaminated sites

Mads Troldborg, Philip John Binning, Signe Nielsen, Peter Kjeldsen et autres

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