Accès ouvert
2026
article
OpenAlex
Tian-Hao Yuan, Yi-Fan Fang, Haiyan Zhang, Hao-Rui Zhang et autres
Background Non-alcoholic fatty liver disease (NAFLD) and diabetic retinopathy (DR) are common clinical complications of metabolic syndrome in different organ systems. However, the relationship between NAFLD and DR remains controversial, and more high-level evidence is needed to clarify the causal link between …
cn
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Accès ouvert
2026
article
OpenAlex
Zhen Yang, Qiuting Li, Zhen‐Sheng Yue, Zhi-Wen Li et autres
BACKGROUND & AIMS: As the global prevalence of obesity continues to rise, metabolic dysfunction-associated steatohepatitis (MASH) has emerged as a significant burden on healthcare systems worldwide. Liver sinusoidal endothelial cells (LSECs) are recognized as crucial regulators of hepatic homeostasis. However, their role …
cn
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Accès ouvert
2025
article
OpenAlex
Yu‐Wei Ling, Juanli Duan, Zijian Jiang, Jingjing Liu et autres
Approximately half of pancreatic cancer patients present with comorbid diabetes. Diabetes is correlated with adverse prognostic outcomes in pancreatic cancer patients, but the underlying mechanism remains elusive. Here, we demonstrate that the cancer-associated endothelial niche is reshaped in the diabetic pancreatic tumor …
cn
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Accès ouvert
2025
article
OpenAlex
Ming Jing Xu, Hao Xu, Yu‐Wei Ling, Jingjing Liu et autres
• Neutrophil extracellular traps (NETs) accumulate in patients and mouse models with NASH. • Elimination of NETs alleviated hepatocyte senescence and hepatic steatosis in NASH mice. • Notch signaling regulates the formation of NASH-associated NETs and cellular senescence. • Notch signaling mitigates …
cn
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Accès ouvert
2025
article
OpenAlex
Fei He, Wei Du, Yingying Liu, Yu‐Wei Ling et autres
Inflammatory mediators tumor necrosis factor (TNF) and interleukin 1 beta (IL1β), primarily derived from hepatic macrophages in the liver, play a crucial role in the progression of nonalcoholic steatohepatitis (NASH). Meanwhile, intravenously injected exosomes are mainly distributed in the liver and predominantly …
cn
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Accès ouvert
2024
article
OpenAlex
Lin Sun, Zhen‐Sheng Yue, Lin Wang
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition, characterized by a spectrum that progresses from simple hepatic steatosis to nonalcoholic steatohepatitis, which may eventually lead to cirrhosis and hepatocellular carcinoma. The precise pathogenic mechanisms underlying NAFLD and its …
cn
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Accès ouvert
2023
article
OpenAlex
Jian Ding, Ming Jing Xu, Wei Du, Zhiqiang Fang et autres
Rationale: Macrophages play a central role in the development and progression of nonalcoholic fatty liver disease (NAFLD).Studies have shown that Notch signaling mediated by transcription factor recombination signal binding protein for immunoglobulin kappa J region (RBP-J), is implicated in macrophage activation and …
cn
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Accès ouvert
2022
review
OpenAlex
Guo-heng Zhang, Tian-Hao Yuan, Zhen‐Sheng Yue, Lin Wang et autres
Background and Objective: Although growing evidence indicates that non-alcoholic fatty liver disease is related to diabetic retinopathy (DR), research results significantly vary. Therefore, we conducted a meta-analysis to assess the association between the progression of non-alcoholic fatty liver disease and the onset …
cn
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2022
article
OpenAlex
Zhiqiang Fang, Bai Ye Ruan, Jingjing Liu, Juanli Duan et autres
BACKGROUND AND AIMS: Although NASH can lead to severe clinical consequences, including cirrhosis and hepatocellular carcinoma, no effective treatment is currently available for this disease. Increasing evidence indicates that LSECs play a critical role in NASH pathogenesis; however, the mechanisms involved in …
cn
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Accès ouvert
2022
article
OpenAlex
Fei He, Weina Li, Xinxin Li, Kangyi Yue et autres
Rationale: Macrophages play multi-dimensional roles in hepatic fibrosis.Studies have implicated Notch signaling mediated by the transcription factor RBP-J in macrophage activation and plasticity.Additionally, we have previously shown that myeloid-specific disruption of RBP-J can ameliorate hepatic fibrosis in mice.Accordingly, we next asked whether …
cn
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Accès ouvert
2022
article
OpenAlex
Juanli Duan, Ziyi Zhou, Bai Ye Ruan, Zhiqiang Fang et autres
Background & Aims Liver sinusoidal endothelial cells (SECs) promote the proliferation of hepatocytes during liver regeneration. However, the specific subset and mechanisms mediating SECs during the process remain unclear. In this study, we investigated the potential role of c-kit + SECs, a …
cn
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Accès ouvert
2021
article
OpenAlex
Tian-Hao Yuan, Zhen‐Sheng Yue, Guo-Heng Zhang, Lin Wang et autres
The communication between organs participates in the regulation of body homeostasis under physiological conditions and the progression and adaptation of diseases under pathological conditions. The communication between the liver and the eyes has been received more and more attention. In this review, …
cn
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