Yuki Sekido

GDF15 promotes 5-Fluorouracil and Oxaliplatin resistance by promoting stem cell-like phenotype in colorectal cancer

Masahiro Hashimoto, Shoichiro Urabe, Tsuyoshi Hata, Yoshinao Chinen et autres

BACKGROUND: Despite recent advances in chemotherapy for colorectal cancer (CRC), chemotherapy-sensitive tumours often develop resistance to treatment, which remains a major clinical challenge. This acquired chemoresistance limits the efficacy of subsequent therapies and is associated with a poor prognosis. Therefore, this study …

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The long-term central venous port for home parenteral nutrition was removed under cardiopulmonary bypass: a case report

Kurumi Tsuchihashi, Takayuki Ogino, Daisuke Yoshioka, Yuki Sekido et autres

Abstract Introduction: Potential complications of long-term use of a central venous port include catheter related bloodstream infection, thrombus formation, and vena cava occlusion. Here, we report an extremely rare case of a patient with Crohn’s disease in whom a central venous port …

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Laparoscopic Sacrectomy as Part of En Bloc Resection for Locally Recurrent Rectal Cancer

Mamoru Uemura, Chikako Kusunoki, Masakatsu Paku, Nobuo Takiguchi et autres

INTRODUCTION: Achieving margin-negative complete resection in locally recurrent rectal cancer often requires en bloc resection involving adjacent structures such as the sacrum. However, sacrectomy is technically demanding and poses a high risk of significant intraoperative bleeding and postoperative pelvic sepsis due to …

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Evaluation of internal iliac vein branching variations in the pelvis using MDCT with precisely defined scanning parameters

Nobuo Takiguchi, Mamoru Uemura, Akira Kida, Mao Osaki et autres

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[The current landscape of surgical treatment for Crohn's disease focusing on laparoscopic surgery].

Takayuki Ogino, Yuki Sekido, Mitsunobu Takeda, Tsuyoshi Hata et autres

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Intraoperative Evaluation of Bladder Perfusion Using Indocyanine Green Fluorescence Imaging During Total Pelvic Exenteration After Interruption of Blood Flow From the Internal Iliac Vessels

Mamoru Uemura, Chikako Kusunoki, Mao Osaki, Hiroshi Kusafuka et autres

ABSTRACT Background In lateral lymph node dissection (LLND) for locally advanced or recurrent rectal cancer, concomitant resection of the internal iliac vessels is sometimes required. Because the bladder receives its primary blood supply from branches of the internal iliac artery, concerns arise …

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Efficacy and Safety of S-1 and Oxaliplatin With Radiotherapy for Anorectal Cancer

Noriko Wada, Naohiro Nishida, Mitsunobu Takeda, Yuki Sekido et autres

BACKGROUND/AIM: Neoadjuvant chemoradiotherapy (CRT) is the standard treatment for locally advanced rectal adenocarcinoma, the optimal regimen remains unknown. For squamous cell carcinoma (SCC), 5-fluorouracil (5-FU) plus mitomycin C (MMC) with radiotherapy (RT) is commonly used; however, alternative medicines are needed for patients …

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ASO Visual Abstract: Inhibition of ACVR1 in Cancer-Associated Fibroblasts Suppresses Colorectal Cancer Cell Growth

Shinya Kato, Norikatsu Miyoshi, Shiki Fujino, Masafumi Horie et autres

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Inhibition of ACVR1 in Cancer-Associated Fibroblasts Suppresses Colorectal Cancer Cell Growth

Shinya Kato, Norikatsu Miyoshi, Shiki Fujino, Masafumi Horie et autres

BACKGROUND: Colorectal cancer (CRC) is the third most common malignancy worldwide and a leading cause of cancer-related mortality. Stromal signatures in CRC are correlated with poor prognosis and resistance to chemotherapy, affecting tumor progression and relapse. Although single-cell analyses have identified subpopulations …

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Intraoperative visualization of lymphatic flow along the ileocolic artery using ICG fluorescence imaging and its implications for right-sided colon cancer surgery

Mamoru Uemura, Chikako Kusunoki, Shoichiro NAKAJO, Mao Osaki et autres

BACKGROUND: In colorectal cancer surgery, especially for right-sided colon cancer, understanding the anatomical course of lymphatic flow along the ileocolic artery (ICA) is crucial for safe and oncologically adequate mesenteric dissection. However, the precise spatial relationship between the ICA and the accompanying …

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Appendectomy Mitigates Ulcerative Colitis Activity and Delays Colorectal Cancer Onset: A Retrospective Cohort Study

Yusuke Izutani, Takayuki Ogino, Makoto Fujii, Yuki Sekido et autres

Background/Aim: Ulcerative colitis (UC) is an idiopathic inflammatory disease with rising global incidence, influenced by genetic, environmental, and immunological factors whose interactions remain unclear. Although the appendix appears to influence UC onset and disease activity, few studies have investigated how the timing …

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Surgery for Rectal Cancer With Mixed Reality of 3D Model During Operation: A Case Report

RIE HAYASHI, Norikatsu Miyoshi, Shiki Fujino, Soichiro Minami et autres

Background/Aim: Recently, robotic surgery for rectal cancer has become a common minimally invasive surgery. In addition, the technology of augmented and mixed reality is applied in various living environments, including medicine. We successfully performed robotic surgery for rectal cancer with three-dimensional (3D) …

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