Joseph A. Thomas

Real-World Treatment Patterns and Survival in Patients with ROS1-Positive Advanced Non-Small Cell Lung Cancer in Canada and Europe

Winson Y. Cheung, Adam Lee, Helena Bote de Cabo, Kathrin Burdenski et autres

Real-world data on patients with ROS1-positive advanced non-small cell lung cancer (NSCLC) remain scarce. In this descriptive observational retrospective cohort study, we describe characteristics, treatments, and real-world progression-free survival (rwPFS) and overall survival (OS) among patients with ROS1-positive advanced NSCLC (de novo …

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EPH155 KRAS Alterations in Advanced Non-Small Cell Lung Cancer (NSCLC): Temporal Trends in Testing Patterns and Targeted Treatment Use Across Europe Between 2018 and 2024

Jens Benn Sørensen, Alan Chalk, Joseph A. Thomas, Joana Guedes de Jesus et autres

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Ethnoracial Disparities in Grey Matter Atrophy in Multiple Sclerosis Are Mediated by Structural Disconnectivity (P9-1.002)

Ahmed Bayoumi, Joseph A. Thomas, John A. Lincoln

To investigate ethnoracial disparities in grey matter (GM) atrophy in multiple sclerosis (MS), and the contribution of white matter lesions and consequent structural disconnectivity.

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Ethnoracial disparities in gray matter atrophy are mediated by structural disconnectivity in multiple sclerosis

Ahmed Bayoumi, Joseph A. Thomas, Breanna Alonzo, Juan Eugenio Jiménez et autres

OBJECTIVE: To investigate ethnoracial disparities in gray matter (GM) atrophy, the contribution of white matter lesions and consequent structural disconnectivity among patients with multiple sclerosis (MS). METHODS: This retrospective study included 297 patients with MS (pwMS), 98 Hispanic/Latinx (H-MS), 82 non-Hispanic Black …

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Assessing White Matter Structural Integrity in MS-Related Tremor Using Diffusion Tensor Imaging

Juan Eugenio Jiménez, Ahmed Bayoumi, Breanna Alonzo, Joseph A. Thomas et autres

Objective To characterize degree of damage along white matter (WM) tracts implicated in multiple sclerosis-related tremor (MS-T). Background Tremor affects up to 50% of patients with multiple sclerosis (pwMS). Current treatments inadequately address etiology and outcomes of MS-T. Diffusion Tensor Imaging (DTI) …

Glymphatic dysfunction in multiple sclerosis and its association with disease pathology and disability

Ahmed Bayoumi, Khader M. Hasan, Joseph A. Thomas, Akram Yazdani et autres

Background: The role of the glymphatic system in multiple sclerosis (MS)-related disability remains underexplored. Diffusion-tensor image analysis along the perivascular space (DTI-ALPS) offers a non-invasive method to assess glymphatic function. Objective: To evaluate glymphatic function in MS patients with lower and higher …

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Magnetic Resonance Image Processing and Analysis Platform (MRI-PAP): A Windows-based Automated Pipeline for Multiple Sclerosis

Alia S. Khaled, Ahmed Bayoumi, Joseph A. Thomas, Refaat E. Gabr et autres

Neurologists and researchers rely on several software tools for neuroimaging data analysis. Limitations in these tools often necessitate the use of more than one program, spanning different coding languages and operating systems, which requires time, effort, and programming skills. MRI-PAP is a …

A case report of severe hypertriglyceridemia induced acute pancreatitis managed with continuous insulin infusion

Joseph A. Thomas

31-year-old male, chronic alcoholic presented to the emergency room with epigastric pain, nausea and vomiting. On examination he was febrile, had abdominal distention with tenderness in the epigastric region. His lipase was elevated and computed tomography of abdomen showed evidence of acute …

Identifying the white matter pathways involved in multiple sclerosis-related tremor using diffusion tensor imaging

Ahmed Bayoumi, Khader M. Hasan, Jorge Patiño, Zafer Keser et autres

Background Tremor affects up to 45% of patients with Multiple Sclerosis (PwMS). Current understanding is based on insights from other neurological disorders, thus, not fully addressing the distinctive aspects of MS pathology. Objective To characterize the brain white matter (WM) correlates of …

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Customized social media-based oncology education.

Uday Kumar Punukollu, Jyothi Jonnadula, Abdul A Rasheed, Purvish Mahendra Parikh et autres

11038 Background: Social media has profoundly impacted our professional lives. Quick access to reliable sources of information and engaging with like-minded experts certainly aids in professional development. The purpose of this study is to assess the perception of oncology experts towards social …

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Challenges in Ethical Medical Practice

Joseph A. Thomas

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A FATAL CASE OF BILATERAL INTERSTITIAL PNEUMONIA (BLIP): INTERFERON ALPHA 2 A INDUCED.

Balaji Ommurugan, Laxminarayana Kurady Bairy, Amita Priya, Joseph A. Thomas et autres

Adult T-cell leukemia/lymphoma (ATLL) is a rare lymph proliferative disorder of mature CD4 T-cells caused by the human T-lymph tropic type 1 (HTLV 1) of retrovirus family. Combination of zidovudine and interferon Alfa combination is one of most commonly used regimen. Many …

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