Johnathan Xiande Lim

Lysine-Specific Demethylase 1 (LSD1) Modulates Hypoxia and Antitumor Immunity Pathways in Triple Negative Breast Cancer

Jabed Iqbal, Dong Yeul Lee, Jing Han Hong, Peiyong Guan et autres

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A comprehensive next generation sequencing tissue assay for Asian-prevalent cancers—Analytical validation and performance evaluation with clinical samples

Cedric Chuan Young Ng, Sandy Lim, Abner Herbert Lim, Nur Diyana Md Nasir et autres

Introduction: A well-validated diagnostic assay with curated biomarkers complements clinicopathological factors to facilitate early diagnosis and ensure timely treatment delivery. This study focuses on an Asian-centric cancer diagnostic assay designed and thoroughly validated against commercially available standard references and a cohort of …

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More microinvasive foci in larger tumours of breast ductal carcinoma in situ

Xiaoyang Chen, Aye Aye Thike, Johnathan Xiande Lim, Boon‐Huat Bay et autres

Introduction: Microinvasion (Mi) is often thought to be an interim stage between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. This study aimed to investigate the potential influence of Mi on survival and assess its correlations with clinicopathological parameters, prognosis and …

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Soft Tissue Leiomyosarcoma With Microsatellite Instability, High Tumor Mutational Burden, and Programmed Death Ligand-1 Expression Showing Pathologic Complete Response to Pembrolizumab: A Case Report

Timothy Kwang Yong Tay, Joe Poh Sheng YEONG, Eileen Xueqin Chen, Xin Xiu Sam et autres

FIG 5. Multiplex immunohistochemistry/immunofluorescence applied to a section of the tumor showed various tumor-infiltrating immune cells: (A) CD3, (B) CD8, (C) CD68, (D) FOXP3, and (E) PD-L1.PD-L1-positive cells (19.7%) were also present.PD-L1, programmed death ligand-1.

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Hypoxia-regulated carbonic anhydrase IX (CAIX) protein is an independent prognostic indicator in triple negative breast cancer

Dong Yeul Lee, Bernett Teck Kwong Lee, Huihua Li, Jeffrey Chun Tatt Lim et autres

BACKGROUND: The effect of extracellular microenvironment (hypoxia and pH) has been regarded as a key hallmark in cancer progression. The study aims to investigate the effects of carbonic anhydrase IX (CAIX), a key hypoxia-inducible marker, in triple-negative breast cancer (TNBC) in correlation …

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Artificial intelligence modelling in differentiating core biopsies of fibroadenoma from phyllodes tumor

Chee Leong Cheng, Nur Diyana Md Nasir, Gary Jian Zhe Ng, Kenny Wei Jie Chua et autres

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Cancer-Testis Antigens in Triple-Negative Breast Cancer: Role and Potential Utility in Clinical Practice

Runyi Adeline Lam, Tracy Zhijun Tien, Craig Ryan Joseph, Johnathan Xiande Lim et autres

Breast cancer cells commonly express tumour-associated antigens that can induce immune responses to eradicate the tumour. Triple-negative breast cancer (TNBC) is a form of breast cancer lacking the expression of hormone receptors and cerbB2 (HER2) and tends to be more aggressive and …

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Correction to: Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma

Jing Quan Lim, Dachuan Huang, Tiffany Pooi Ling Tang, Daryl Chen Lung Tan et autres

A Correction to this paper has been published: https://doi.org/10.1038/s41375-021-01195-4

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Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma

Jing Quan Lim, Dachuan Huang, Tiffany Pooi Ling Tang, Daryl Chen Lung Tan et autres

Antibodies targeting the immune checkpoint axis have been approved by the FDA for the treatment of a broad range of malignancies [ 1 ]. NKTCL is an aggressive hematological malignancy derived from NK or T cells with ubiquitous Epstein–Barr virus (EBV) infection, …

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Tertiary lymphoid structures and associated plasma cells play an important role in the biology of triple-negative breast cancers

Dominique Yuan Bin Seow, Joe Poh-Sheng Yeong, Johnathan Xiande Lim, Noel Chia et autres

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Multiplex immunohistochemistry/immunofluorescence (mIHC/IF) for PD-L1 testing in triple-negative breast cancer: a translational assay compared with conventional IHC

Joe Poh-Sheng Yeong, Tira J. Tan, Zi Long Chow, Qing Cheng et autres

BACKGROUND: patient subgroup of the recent IMpassion130 trial. The SP142 PD-L1 antibody clone was used as a predictive assay in this trial, but this clone was found to be an outlier in previous harmonisation studies in lung cancer. AIMS: To address the …

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Youth in Action for Health Project: Peer Health Promoters Making a Difference

Annette E. Aalborg, Kimberly Orozco, Dennis H. Knight, R. G. C. Ramos et autres