Muhammad Ali

Efficacy and safety of the antithrombin siRNA fitusiran as prophylaxis in haemophilia a and B: A systematic review and meta-analysis

Muhammad Usama, Muhammad Rafay Paracha, Dania Hussain, Amal Khan et autres

Abstract Introduction: The management of bleeding in individuals with Haemophilia A and B has proven to be challenging. Conventional treatments that involve the infusion of clotting factors are both intensive and cost-prohibitive for many patients. Fitusiran, a novel investigational agent, presents a …

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Evaluating the correlation between the quantra hemostasis system and rotational thromboelastometry (ROTEM) for viscoelastic hemostatic assessment: A systematic review and meta-analysis.

Muhammad Usama, Muhammad Rafay Paracha, Dania Hussain, zahra ali haque et autres

Abstract Introduction/Background: Perioperative and trauma-induced coagulopathy considerably contributes to morbidity and mortality. While Rotational Thromboelastometry (ROTEM) remains a cornerstone for viscoelastic coagulation assessment, its operational complexity may limit its utility in emergency and urgent care settings. The Quantra Hemostasis System, a fully …

us, pk, uz (code pays fourni par la source)

S2812 Trends and Disparities in Mortality Related to Fibrosis and Cirrhosis of the Liver Along With Sepsis in Adults ≥65 Years From 1999 to 2023 in the United States

Khizar Hayat, Muhammad Ali, Dania Hussain, Saif Ur Rehman et autres

Introduction: Fibrosis and cirrhosis of the liver are bidirectionally linked with sepsis, with their coexistence leading to worse outcomes and higher mortality. Sepsis promotes hepatic injury through inflammation, dysbiosis, and hepatocyte damage, while cirrhosis and fibrosis worsen sepsis via immune dysfunction and …

S2810 Trends and Disparities in Liver Disease and Renal Failure-Related Mortality in Adults ≥65 Years From 1999 to 2023 in the United States

Khizar Hayat, Muhammad Ali, Komal Khalid, Dania Hussain et autres

Introduction: Liver disease (LD) and renal failure (RF) are interrelated, as their concurrence is associated with dire outcomes and accelerated mortality. Cirrhosis can precipitate RF, as in hepatorenal syndrome, while RF may also exacerbate hepatic dysfunction. Research on LD and RF-related mortality …

The second survey of the Saudi Acute Myocardial Infarction Registry Program: Main results and temporal changes in care (STARS-2 program)

Shukri M. AlSaif, Osama Alhadramy, Mohammed Alshehri, Khalid Al Faraidy et autres

BACKGROUND: The Saudi Acute Myocardial Infarction Registry (STARS) program aims to evaluate the clinical characteristics, management, and outcomes of a representative sample of patients with acute myocardial infarction (AMI) in Saudi Arabia. This second phase evaluates temporal changes in patient care, demographics, …

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PATIENT PERSPECTIVES ON TELEHEALTH CARDIAC REHABILITATION AFTER MYOCARDIAL INFARCTION

Habib Gul, Rizwana Yasmin, Muhammad Ali, Farwa Rizvi et autres

Background: Despite the proven benefits of cardiac rehabilitation (CR) post-myocardial infarction (MI), participation rates remain low due to logistical, geographical, and psychosocial barriers. Telehealth-delivered CR offers a promising solution, especially in resource-constrained settings. However, limited qualitative evidence exists on how patients experience …

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Mechanisms of azithromycin resistance in Salmonella Typhi : molecular insights from dynamics behavior to clinical implications

Syeda Farishta, Rani Faryal, Muhammad Waqas, Muhammad Ali et autres

The widespread use of azithromycin during the COVID-19 pandemic has likely contributed to the increased resistance of Salmonella Typhi to this antibiotic. This study focuses on the extensive drug resistance (XDR) of Salmonella Typhi in Pakistan, analyzing 11,916 suspected typhoid fever cases, …

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Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis

Abdullah Bin Kamran, Ahmed Bazil Bin Khalil, Ayesha Muhammad, Hira Arshad et autres

INTRODUCTION: Acute ischemic stroke (AIS) is a leading cause of morbidity and mortality globally. Standard antiplatelet therapies, while partially effective, do not fully inhibit all pathways of platelet aggregation, leaving patients at risk of recurrent thrombotic events. Tirofiban, a glycoprotein IIb/IIIa receptor …

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Author response for "Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis"

Abdullah Bin Kamran, Ahmed Bazil Bin Khalil, Ayesha Muhammad, Fatima Nazir et autres

Author response for "Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis"

Abdullah Bin Kamran, Ahmed Bazil Bin Khalil, Ayesha Muhammad, Fatima Nazir et autres

p-Cymene inhibits pro-fibrotic and inflammatory mediators to prevent hepatic dysfunction

Muhammad Atif, Muhammad Nasir Hayat Malik, Tariq G. Alsahli, Muhammad Ali et autres

Abstract This study evaluated the hepatoprotective potential of p-cymene (p-CYM) against two models of liver damage: ethanol (EtOH)-induced hepatocellular injury and diethylnitrosamine-carbon tetrachloride (DEN-CCl 4 )-induced liver fibrosis (LF). HepG2 cells were treated with p-CYM or silymarin (SIL) before exposure to 10% …

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Clinical features, socioeconomic status, management, short and long-term outcomes of patients with acute myocardial infarction: Phase I results of PEACE MENA registry

Ayman Al Saleh, Amal Jamee, Kadhim Sulaiman, Mohamed Sobhy et autres

BACKGROUND: The Program for the Evaluation and Management of Cardiac Events in the Middle East and North Africa (PEACE MENA) is a prospective registry program in Arabian countries that involves in patients with acute myocardial infarction (AMI) or acute heart failure (AHF). …

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