Naijian Ge

A Dynamic Prognostic and Adaptive Treatment Framework for Advanced Biliary Tract Cancer

Jiakun Mei, Xue Han⊗, Kai Zhang, Naijian Ge et autres

BACKGROUND & AIMS: First-line immuno-chemotherapy is standard for advanced biliary tract cancer (BTC), but outcomes vary substantially, necessitating longitudinal monitoring and treatment adaptation. We aimed to develop models that dynamically update survival predictions using evolving clinical data to support real-time prognostic stratification. …

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Machine Learning–Guided Personalized Immunochemotherapy Strategies in Intrahepatic Cholangiocarcinoma

Jiakun Mei, Kai Zhang, Ying Zhang, Zhen Li et autres

BACKGROUND & AIMS: Immunochemotherapy (IO-chemo) has become standard care for patients with unresectable intrahepatic cholangiocarcinoma (iCCA), but benefit of adding IO varies greatly among individuals. We sought to develop a system to identify patients most likely to benefit from this treatment based …

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Portal vein embolization for arterio-portal shunt closure in hepatocellular carcinoma to facilitate selective internal radiation therapy

Xue Liu, Jin-Yan Zhao, Zhen-Yuan Xu, Shuqun Shen et autres

BACKGROUND: Selective internal radiation therapy (SIRT) has been widely used in the treatment of hepatocellular carcinoma (HCC). However, marked intrahepatic shunt (IHS) secondary to arterio-portal shunt (APS) often precludes safe SIRT administration. AIM: To evaluate the efficacy and safety of portal vein …

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Coil-assisted N-butyl cyanoacrylate embolization vs covered stent implantation for delayed hemorrhage in hepatobiliary and pancreatic surgery

Cheng-Jian He, Xiangdong Wang, Naijian Ge, Xue Liu et autres

BACKGROUND Hemorrhage following pancreaticobiliary surgery is a high-risk complication, with a mortality rate of 16%-38%. At present, minimally invasive endovascular intervention comprising superselective arterial embolization (SAE) and covered stent implantation (CSI) is the treatment of choice. However, in certain cases, both SAE …

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Plasma treated NiTi stents for antithrombosis and antibacterial infection by ammonia generation and surface charge regulation

Chao Wei, Ji Tan, Shun Xing, Hongqin Zhu et autres

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Massive gastrointestinal hemorrhage and iodine-125 seed migration due to hepatogastric fistula: a case report and literature review

Chengjian He, Jing Zhou, Naijian Ge, Xiaofeng Zhang et autres

Background: I) seed migration to the stomach through HGF not previously documented. This report explores this unique case and reviews other recent instances of rare gastrointestinal hemorrhage due to HGF. Case Description: I seed implantation, the patient presented with severe upper gastrointestinal …

Apatinib plus hepatic arterial infusion of oxaliplatin and raltitrexed for hepatocellular carcinoma with extrahepatic metastasis: phase II trial

Shiguang Chen, Xiangdong Wang, Bo Yuan, Jianyang Peng et autres

Most patients with advanced hepatocellular carcinoma (HCC) ultimately experience tumor progression after first-line systemic therapies. Systemic therapy is generally recommended as second-line treatment for advanced HCC in the major guidelines. Combining apatinib with hepatic arterial infusion chemotherapy (HAIC) likely drives synergistic activity …

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Radiation-emitting metallic stent for unresectable Bismuth type III or IV perihilar cholangiocarcinoma: a multicenter randomized trial

Qi Chen, Naijian Ge, Yuliang Li, Ming Xing Huang et autres

BACKGROUND AND AIMS: Self-expandable metallic stents (SEMSs) have been recommended for patients with unresectable malignant biliary obstruction, while radiation-emitting metallic stents (REMSs) loaded with 125 I seeds have recently been approved to provide longer patency and overall survival in malignant biliary tract …

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Fusible and Radiopaque Microspheres for Embolization

Jing Li, Jingyi Xu, Yunpeng Wang, Yue Chen et autres

Abstract In this work, fusible microspheres loaded with radiopaque agents as an embolic agent for transcatheter arterial embolization (TAE) are developed. A poly(ethylene glycol) (PEG) and poly(ε‐caprolactone) (PCL) multi‐block copolymer basing polyurethane (PCEU) is synthesized and fabricated into blank microspheres (BMs). The …

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NIR-triggered arsenic-loaded layered double hydroxide-based films for localized thermal synergistic chemotherapy

Shun Xing, Haifeng Zhang, Zhenhao Hou, Feng Peng et autres

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Selective Tumor Inhibition Effect of Drug-Free Layered Double Hydroxide-Based Films via Responding to Acidic Microenvironment

Shun Xing, Haifeng Zhang, Lidan Liu, Donghui Wang et autres

Nickel–titanium alloy stents are widely used in the interventional treatment of various malignant tumors, and it is important to develop nickel–titanium alloy stents with selective cancer-inhibiting and antibacterial functions to avoid malignant obstruction caused by tumor invasion and bacterial colonization. In this …

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Immune checkpoint inhibitors and anti-vascular endothelial growth factor antibody/tyrosine kinase inhibitors with or without transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma (CHANCE2201): a target trial emulation study

Zhi‐Cheng Jin, Jian-Jia Chen, Xiaoli Zhu, Yujing Xin et autres

Background: The role of transarterial chemoembolization (TACE) in the treatment of advanced hepatocellular carcinoma (HCC) is unconfirmed. This study aimed to assess the efficacy and safety of immune checkpoint inhibitors (ICIs) plus anti-vascular endothelial growth factor (anti-VEGF) antibody/tyrosine kinase inhibitors (TKIs) with …

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