Xiufeng Zhao

基于梯度折射率透镜的微型头戴式荧光显微镜设计

Bing-Hui Shan, Xiufeng Zhao, Fan-yu Liu, Jing-yi MA et autres

在对自由移动的动物进行脑神经实时观测时，微型头戴式荧光显微镜是当前最为前沿的脑科学观测仪器之一。但是，现今多数微型荧光显微镜为了达到体积和重量的严格限制，使得视场较小，无法同时观测多个脑区的神经活动，而少数视场大的产品重量较大，无法佩戴在小型动物身上。本研究使用轻量化、平面化和成像质量高的梯度折射率透镜，在保证大视场的前提下，减小了显微镜的重量。本文使用梯度折射率透镜进行大视场微型荧光显微镜设计，推导了倾斜光线入射梯度折射率透镜时的离轴像差公式，分析了梯度折射率透镜的折射率排布模型和像差校正情况，并据此设计了一款微型荧光显微镜，其视场为4 mm×4 mm，NA为0.1，样机重量仅为2.89 g，中心视场分辨率为13.9 μm，初步达到了自由移动小鼠的脑神经细胞分辨率。

Baricitinib ameliorates skin fibrosis via direct fibroblast suppression and endothelial exosome-mediated paracrine signaling

Zhanying Hou, Xiufeng Zhao, Fang Liu, Shi Xu

BACKGROUND: Novel therapies are urgently needed for diffuse cutaneous systemic sclerosis (dcSSc). Aberrant JAK/STAT signaling drives fibrosis, but JAK inhibitors’ effects on vascular pathology and potential synergy with endothelial-derived exosomes remain unclear. METHODS: Utilizing bleomycin (BLM)-induced human skin fibroblast (HSF) activation and …

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Novel compound heterozygous ALPK3 mutations (c.4234C>T and c.3491G>A), causing hypertrophic cardiomyopathy treated with the liwen procedure: case report

Wenjing Liu, Hua Yang, Feng-Hui Jiao, Haiying Hu et autres

Background Hypertrophic cardiomyopathy (HCM) is an autosomal dominant cardiovascular disease characterised by myocardial hypertrophy with a prevalence of approximately 0.2%–0.5%. Recently, in addition to mutations in genes encoding sarcomeric proteins, which have traditionally been implicated in the development of HCM, mutations in …

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Ultrasonic assisted surfactant/HPAM synergistic purification of highly emulsified oilfield produced water

Jinjun Deng, Zeyu Gu, Xin Zhang, Yanbin Tong et autres

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Tafazzin-Mediated Cardiolipin Remodeling Controls Metabolic Stress Response and Effector Function of Inflammatory T Cells

Xiufeng Zhao, Sophia Hochrein, Miriam Eckstein, Hao Wu et autres

SUMMARY Clonal expansion and effector differentiation of T cells require extensive metabolic reprogramming. This includes the restructuring of the inner mitochondrial membrane (IMM) to enhance respiration by increasing chemiosmotic coupling efficiency. Cardiolipin, a unique phospholipid that is exclusively synthesized and localized in …

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Advances in the Experimental Research on the Surface Integrity in the Cutting of Titanium Alloy

Ruifang Huang, Guohe Li, Xiufeng Zhao, Qiuqiu Qiao et autres

Background: Titanium alloy, as a high-strength alloy material, has been widely used in aerospace and other fields due to its high specific strength, good corrosion resistance, super fracture toughness, and fatigue resistance. However, its small elastic modulus, low thermal conductivity, and strong …

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Akkermansia muciniphila : a deworming partner independent of type 2 immunity

Jiaqi Wang, Xiufeng Zhao, Xianhe Li, Xuemin Jin

The gut microbiota has coevolved with the host for hundreds of millions of years, playing a beneficial role in host health.Human parasitic helminths are widespread and pose a pervasive global public health issue.Although Type 2 immunity provides partial resistance to helminth infections, …

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Exploration and Design of Experimental Teaching on Ultrasonic-Enhanced Synergistic Treatment of Ternary Composite Flooding Produced Water

Zhangshu Wang, Xin Zhang, Jixin Han, Xuebing Fang et autres

Ceramides and metabolic profiles of patients with acute coronary disease: a cross-sectional study

Liang Zhang, Da‐Wei Tan, Yang Zhang, Yaodong Ding et autres

Metabolic Syndrome (MS) is a rapidly growing medical problem worldwide and is characterized by a cluster of age-related metabolic risk factors. The presence of MS increases the likelihood of developing atherosclerosis and significantly raises the morbidity/mortality rate of acute coronary syndrome (ACS) …

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Association of age-adjusted Charlson comorbidity index with adverse outcomes in patients undergoing transcatheter aortic valve replacement: A retrospective cohort study

Hua Yang, Limin Meng, Shuanli Xin, Chao Chang et autres

Patients undergoing transcatheter aortic valve replacement (TAVR) have a high comorbid burden. Our objective was to assess the association between the age-adjusted Charlson comorbidity index (Age-CCI) and mortality and readmission rates within 1-year post-TAVR. Data were extracted from the Medical Information Mart …

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Non-linear association between aspartate aminotransferase to alanine aminotransferase ratio and mortality in critically ill older patients: A retrospective cohort study

Hua Yang, Limin Meng, Shuanli Xin, Chao Chang et autres

BACKGROUND: The aspartate aminotransferase to alanine aminotransferase (AST/ALT) ratio has been shown to be associated with poor clinical outcomes across various patient groups. However, little is unclear about the association between the two in critically ill older patients. Therefore, we aim to …

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Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming

Hao Wu, Xiufeng Zhao, Sophia M. Hochrein, Miriam Eckstein et autres

T cell exhaustion is a hallmark of cancer and persistent infections, marked by inhibitory receptor upregulation, diminished cytokine secretion, and impaired cytolytic activity. Terminally exhausted T cells are steadily replenished by a precursor population (Tpex), but the metabolic principles governing Tpex maintenance …

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