Jianyuan Zhao

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Yuan Zhang, Cancan Yao, Y S Chen, Ke Cai et autres

G3BP1, GTPase activating protein (SH3 domain) binding protein 1, is a core component of stress granules. Homozygous null mutations in the G3bp1 gene result in embryonic lethality, underscoring its essential role in development. While various post-translational modifications regulate G3BP1 activity, here we …

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RUNX1 N6-methyladenosine methylation enhances cytoskeleton remodelling and boosts cardiac fibrosis

Ji-Fei Ding, Zhenyu Liu, Bin Tu, Lei Gao et autres

AIMS: The RUNX family of transcription factors is critical for heart development, physiology, and cardiovascular disease. However, current models of transcription factor binding seldom incorporate RNA modifications, and the latest methods that include them remain limited. This gap impedes accurate profiling of …

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Redefining the Global Landscape of Methicillin-Resistant Staphylococcus aureus Infection Burdens: Epidemiology, Challenges, and Future Directions

Zhanghua Yin, Jintong Tan, Xinzhu Liu, Yanjun Li et autres

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SLFN14 functions as a P-TEFb inhibitor to modulate the transcription of HIV-1 and cellular genes

Ling Ma, Zhen Wang, Quanjie Li, Rui Zhou et autres

) gene family encodes different growth regulatory factors known to participate in cell growth, differentiation, tumorigenesis, and the immune response against virus infection. However, the molecular mechanisms underlying their functions remain largely incomplete. In this study, we report that the SLFN family …

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Epigenetics of mitochondrial and inflammation in cardiac fibrosis

Huanhuan He, Li-Chan Lin, Zhenyu Liu, Peng Liu et autres

Cardiac fibrosis (CF) is a reactive remodeling process that occurs in response to myocardial injury. It is characterized by the accumulation of extracellular matrix (ECM) proteins in the cardiac interstitium, resulting in thickening of the myocardial wall and impaired cardiac function. This …

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New insights into applications of base editor in hereditary disorders

Maoping Cai, Linhui Zhang, Liqing Li, Guoyun Liu et autres

Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even …

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Host lncRNA assists the nuclear import of influenza A virus protein PB2 in a species-specific manner

Jing Wang, Saisai Guo, Jianyuan Zhao, Tingting Sun et autres

Long noncoding RNAs (lncRNAs) have been reported to modulate immune responses to viral infections. However, it remains largely unexplored how viruses exploit host lncRNAs to promote viral replication. Here, we found that an lncRNA, called lnc-ALOX12, is upregulated specifically in cells infected …

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SLFN11 Restricts LINE-1 Mobility

Zhongjie Ye, Yuqing Duan, Ao Zhang, Zixiong Zhang et autres

Long interspersed element-1 (LINE-1) is the only active autonomous transposon comprising about 17% of human genomes. LINE-1 transposition can cause the mutation and rearrangement of the host's genomic DNA. The host has, therefore, developed multiple mechanisms to restrict LINE-1 mobility. Here, we …

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Maximal inhibitory effect of MOV10 on LINE-1 retrotransposition requires both the MOV10/LINE-1 association and granule formation

Qian Liu, Yaqi Liu, Yang Mao, Dongrong Yi et autres

LINE-1 is the only active autonomous mobile element in the human, and its mobilization is tightly restricted by the host to maintain genetic stability. We recently reported that human MOV10 recruits DCP2 to decap LINE-1 RNA by liquid-liquid phase separation (LLPS), resulting …

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High fructose levels inhibit the proliferation of cardiomyocytes via the Notch1 signaling pathway

Fei Ma, Xiji Qin, Junjie Yang, Xin Zhou et autres

Fructose, as a natural and simple sugar, is not significantly harmful to the human body when consumed in moderation and can provide energy for the body. High-fructose diets have been linked to an increased risk of a range of metabolic disorders, including …

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Novel virulence determinants in VP1 regulate the assembly of enterovirus-A71

Wenjing Zhang, Quanjie Li, Dongrong Yi, Ruifang Zheng et autres

Enterovirus-A71 (EV-A71) is the second most common causative agent after coxsackievirus A16 of hand, foot, and mouth disease. The capsids of EV-A71 consist of 60 copies of each of the four viral structural proteins (VP1-VP4). VP1 is highly exposed and surface accessible, …

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Identification of immune-associated genes involved in latent Mycobacterium marinum infection

Pingping Jia, Shize Peng, Yi Zhang, Jianyuan Zhao et autres

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