Song-Chou Hsieh

Signal or noise? Apply myositis autoantibody line-blot immunoassays in real-world settings: implications for diagnostic accuracy

Pei-Hsinq Lai, Chiao‐Feng Cheng, Tai-Ju Lee, Jheng-Wei Lin et autres

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Distinct trajectory of gut microbiota driven by a human oral commensal: insights from a murine study

Wei‐Ting Lin, Shiao‐Pieng Lee, Chin Li, Chia-Bin Chang et autres

Background Oral microbes modulate the gut microbiota. Haemophilus parainfluenzae, a core human oral commensal with immunomodulatory properties, is reduced in autoimmune diseases, while mitigating Sjögren's syndrome-like disease with improved oral microbiota in female NOD mice. However, whether it modulates the gut microbiota …

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The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies

Hsin‐Chou Yang, Pui–Yan Kwok, Ling-Hui Li, Yimin Liu et autres

Abstract Han Chinese people comprise nearly 20% of the global population but remain under-represented in genetic studies 1,2 , so there is an urgent need for large-scale cohorts to advance precision medicine. Here we present the Taiwan Precision Medicine Initiative (TPMI), established …

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A systematic review and network meta-analysis of cardiovascular safety of benzbromarone compared to febuxostat and allopurinol in patients with gout

Ting‐Syuan Lin, Yen-Liang Lin, Chiu-Hao Hsu, Song-Chou Hsieh et autres

Background: Gout is caused by hyperuricemia and is associated with cardiovascular diseases. Treatment for hyperuricemia primarily involves urate-lowering medications. Some trials showed higher cardiovascular mortality rates with febuxostat compared to allopurinol in gout patients. However, data on the cardiovascular safety of benzbromarone …

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RISK FACTORS FOR DE NOVO LUPUS NEPHRITIS IN NON-RENAL SLE PATIENTS TREATED WITH AZATHIOPRINE

Tai-Ju Lee, Ting‐Yuan Lan, Chen-Hsun Lu, Chieh‐Yu Shen et autres

PV130 / #54 Poster Topic: AS15 - Lupus Nephritis-Clinical Background/Purpose Lupus nephritis (LN) is 1 of the most common, potentially organ threatening, and even fatal complications for patients living with systemic lupus erythematosus (SLE). The initial signs of lupus nephritis include persistent …

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The Taiwan Precision Medicine Initiative: A Cohort for Large-Scale Studies

Hsin‐Chou Yang, Pui–Yan Kwok, Ling-Hui Li, Yimin Liu et autres

Abstract The Taiwan Precision Medicine Initiative (TPMI), a project initiated by the Academia Sinica in collaboration with 16 major medical centers around Taiwan, has recruited 565,390 participants who consented to provide DNA samples for genetic profiling and grant access to their electronic …

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Advanced Glycation End-Products Acting as Immunomodulators for Chronic Inflammation, Inflammaging and Carcinogenesis in Patients with Diabetes and Immune-Related Diseases

Chieh‐Yu Shen, Cheng‐Hsun Lu, Chiao‐Feng Cheng, Ko‐Jen Li et autres

Increased production of advanced glycation end products (AGEs) among reducing sugars (glucose, fructose, galactose, or ribose) and amino acids/proteins via non-enzymatic Maillard reaction can be found in lifestyle-related disease (LSRD), metabolic syndrome (MetS), and obesity and immune-related diseases. Increased serum levels of …

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Successful Treatment of a Critically Ill COVID-19 Patient Using Continuous Renal Replacement Therapy With Enhanced Cytokine Removal and Tocilizumab: A Case Report

Thomas Tao-Min Huang, Ying‐Chun Chien, Chih‐Hsien Wang, Sui‐Yuan Chang et autres

The COVID-19 pandemic has caused multiple deaths worldwide. Since no specific therapies are currently available, treatment for critically ill patients with COVID-19 is supportive. The most severe patients need sustained life support for recovery. We herein describe the course of a critically …

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Potential serum and urine biomarkers in patients with lupus nephritis and the unsolved problems

Chia‐Li Yu, Song-Chou Hsieh, Chang‐Youh Tsai

Lupus nephritis (LN) is one of the most frequent and serious complications in the patients with systemic lupus erythematosus. Autoimmune-mediated inflammation in both renal glomerular and tubulointerstitial tissues is the major pathological finding of LN. In clinical practice, the elevated anti-dsDNA antibody …

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Swollen Toes with Skin Eruptions

Lung‐Fang Chen, Cheng‐Hsun Lu, Song-Chou Hsieh, Ko‐Jen Li

A 28-year-old man developed erythematous changes in his toes, including swelling with local tenderness after visiting a hot spring one month earlier.The lesions progressively spread to the bilateral foot days later, with onycholysis (Picture A, C), and increased despite the use of …

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Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study

Tai-Ming Ko, Chang‐Youh Tsai, Shih-Yang Chen, Kuo-Shu Chen et autres

OBJECTIVE: To evaluate the use of prospective screening for the HLA-B*58:01 allele to identify Taiwanese individuals at risk of severe cutaneous adverse reactions (SCARs) induced by allopurinol treatment. DESIGN: National prospective cohort study. SETTING: 15 medical centres in different regions of Taiwan, …

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Activated Human Valvular Interstitial Cells Sustain Interleukin-17 Production To Recruit Neutrophils in Infective Endocarditis

Chiou-Yueh Yeh, Chia‐Tung Shun, Yu‐Min Kuo, Chiau‐Jing Jung et autres

The mechanisms that underlie valvular inflammation in streptococcus-induced infective endocarditis (IE) remain unclear. We previously demonstrated that streptococcal glucosyltransferases (GTFs) can activate human heart valvular interstitial cells (VIC) to secrete interleukin-6 (IL-6), a cytokine involved in T helper 17 (Th17) cell differentiation. …

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