Don W. Arnold

Acoustic Ejection Mass Spectrometry for High-Throughput Analysis

Hui Zhang, Chang Liu, Wenyi Hua, Lucien P. Ghislain et autres

We describe a mass spectrometry (MS) analytical platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port interface (OPI), and electrospray ionization (ESI)-MS that creates a transformative system enabling high-speed sampling and label-free analysis. The ADE technology delivers …

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Acoustic Ejection Mass Spectrometry for High-Throughput Analysis

Hui Zhang, Chang Liu, Wenyi Hua, Lucien P. Ghislain et autres

Abstract We describe a mass spectrometry (MS) analytical platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port interface (OPI), and electrospray ionization (ESI) MS that creates a transformative system enabling high-speed sampling and label-free analysis. The ADE …

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A novel microchip‐based imaged CIEF‐MS system for comprehensive characterization and identification of biopharmaceutical charge variants

Scott Mack, Don W. Arnold, Greg Bogdan, Luc Bousse et autres

A microfluidic system has been designed that integrates both imaged capillary isoelectric focusing (iCIEF) separations and downstream MS detection into a single assay. Along with the construction of novel instrumentation and an innovative microfluidic chip, conversion to MS-compatible separation reagents has also …

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Fast quantitation of opioid isomers in human plasma by differential mobility spectrometry/mass spectrometry via SPME/open-port probe sampling interface

Chang Liu, Germán Augusto Gómez‐Ríos, Bradley B. Schneider, J. C. Yves Le Blanc et autres

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Open Port Probe Sampling Interface for the Direct Coupling of Biocompatible Solid-Phase Microextraction to Atmospheric Pressure Ionization Mass Spectrometry

Germán Augusto Gómez‐Ríos, Chang Liu, Marcos Tascón, Nathaly Reyes‐Garcés et autres

High Resolution Image Download MS PowerPoint Slide In recent years, the direct coupling of solid phase microextraction (SPME) and mass spectrometry (MS) has shown its great potential to improve limits of quantitation, accelerate analysis throughput, and diminish potential matrix effects when compared …

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Micro-LC–MS/MS: The Future of Bioanalysis

Don W. Arnold, Shane Needham

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Evaluation of micro ultra high pressure liquid chromatography for pharmaceutical analysis

Monica Yang, Xiaoyi Gong, Wes Schafer, Don W. Arnold et autres

The Eksigent ExpressLC Ultra micro high pressure LC system was evaluated and found to provide separation efficiency and system reproducibility comparable with conventional HPLC instruments, albeit with somewhat higher UV detector noise. The dwell volume of the system was measured and found …

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Micro-LC-MS/MS: the future of bioana lysis "Researchers using current micro-LC-MS systems can realize benefits of high-pressure chromatography and advanced particle technologies in addition to the innate speed, sensitivity and cost benefits of micro-LC in their bioanalytical laboratories."

Don W. Arnold

On-Chip Single-Copy Real-Time Reverse-Transcription PCR in Isolated Picoliter Droplets

N. Reginald Beer, Elizabeth K. Wheeler, Lorenna Lee-Houghton, Nicholas N. Watkins et autres

The first lab-on-chip system for picoliter droplet generation and RNA isolation, followed by reverse transcription, and PCR amplification with real-time fluorescence detection in the trapped droplets has been developed. The system utilized a shearing T-junction in a fused-silica device to generate a …

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Microchip separations of protein biotoxins using an integrated hand‐held device

Julia A. Fruetel, Ronald F. Renzi, Victoria A. VanderNoot, James Stamps et autres

We report the development of a hand-held instrument capable of performing two simultaneous microchip separations (gel and zone electrophoresis), and demonstrate this instrument for the detection of protein biotoxins. Two orthogonal analysis methods are chosen over a single method in order to …

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A VCSEL-based micro-optical fluorescence detection system for capillary electrochromatography

Mial E. Warren, J. R. Wendt, William C. Sweatt, Christopher G. Bailey et autres

Summary form only given. We are currently exploring the use of vertical-cavity surface-emitting lasers (VCSELs) and planar diffractive optics for miniaturized chemical analysis systems that combine capillary separation techniques with optical fluorescence detection. Chemical analysis based on capillary separations, such as capillary …

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COMMUNICATIONS Anion photoelectron spectroscopy of iodine-carbon dioxide clusters

Don W. Arnold, Stephen E. Bradforth, Eun Ha Kim, Daniel M. Neumarkb

Anion photoelectron spectroscopy has proved to be a powerful method for the study of molecular clusters because it combines mass-selectivity and reasonable spectral resolution. Anion photoelectron spectra have been reported for elemental and molecular clusters of the type Ai, in which the …