Li An Lin

Neurophysiolgical implications in sialidosis type 1: a case report

Fei Wang, Li An Lin, Jing Hu, Jianfang Zhang et autres

Sialidosis is a rare autosomal recessive hereditary disease caused by NEU1 gene mutations. A 25-year-old woman developed generalized tonic-clonic seizures since teenage, followed by progressive visional decline and limb myoclonus. Her sister had similar presentations. Both patients were products of a consanguineous …

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Adaptive Randomization for Master Protocols in Precision Medicine

Jianchang Lin, Li An Lin, Veronica Bunn, Rachael Liu

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Exome-wide association study of plasma lipids in >300,000 individuals

Dajiang J. Liu, Gina M. Peloso, Haojie Yu, Adam S. Butterworth et autres

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Exome-wide association study of plasma lipids in > 300,000 individuals

Dajiang J. Liu, Gina M. Peloso, Haojie Yu, Adam S. Butterworth et autres

We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-densitylipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 …

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Georg Ehret, Teresa Ferreira, Daniel I. Chasman, Ellen M. Schmidt et autres

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We …

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

Hieab H.H. Adams, Hadie Adams, Lenore J. Launer, Sudha Seshadri et autres

Abstract Joint analysis of data from multiple studies in collaborative efforts strengthens scientific evidence, with the gold standard approach being the pooling of individual participant data (IPD). However, sharing IPD often has legal, ethical, and logistic constraints for sensitive or high-dimensional data, …

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A General Overview of Adaptive Randomization Design for Clinical Trials

Jianchang Lin, Li An Lin

With the recent release of FDA draft guidance (2010), adaptive designs, including adaptive randomization (e.g. response-adaptive (RA) randomization) has become popular in clinical trials because of its advantages of flexibility and efficiency gains, which also have the significant ethical advantage of assigning …

A Bayesian Response-adaptive Covariate-adjusted Randomization Design for Clinical Trials

Jianchang Lin, Li An Lin

Accordingly to FDA draft guidance (2010), adaptive randomization (e.g. response-adaptive (RA) randomization) has become popular in clinical research because of its flexibility and efficiency, which also have the advantage of assigning fewer patients to inferior treatment arms. However, these designs lack a …

Abstract 148: Whole Exome Sequence Analysis of Cerebral White Matter Hyperintensities on MRI

Myriam Fornage, Vincent Chouraki, Li An Lin, Anita L. DeStefano et autres

White matter hyperintensities (WMH) detected on MRI are commonly identified abnormalities in the adult brain, and are associated with a greater risk of stroke, dementia, and death. Genetic factors play a significant role in WMH etiology, yet, common genetic variants identified by …

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Design and Analysis of Clinical Trials, and Analysis of Correlated Data

Li An Lin