Rennert Gad

Targeted Prostate Cancer Screening in Carriers of BRCA1 or BRCA2 Pathogenic Germline Variants Detects Clinically Relevant Disease: 5-year Results from the IMPACT Study

Elizabeth K. Bancroft, Elizabeth C. Page, Jana McHugh, Sarah Thomas et autres

BACKGROUND AND OBJECTIVE: BRCA1 and BRCA2 pathogenic germline variants (PGVs) are associated with higher risk of prostate cancer (PC). The IMPACT study evaluated the utility of targeted prostate-specific antigen (PSA) screening in BRCA1/BRCA2 PGV carriers. Here we report outcomes after five rounds …

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Genetic risk factors modulate the association between physical activity and colorectal cancer

Anita R. Peoples, Mireia Obón-Santacana, Andre E. Kim, Eric S. Kawaguchi et autres

Physical activity is an established protective factor for colorectal cancer (CRC), but it is unclear if genetic variants modify this effect. To investigate this possibility, we conducted a genome-wide gene–physical activity interaction analysis. Using logistic regression (1-d.f), two-step screening and testing method …

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Genomic risk model to implement precision prostate cancer screening in clinical care: the ProGRESS study

Jason L. Vassy, Anna Dornisch, Roshan Karunamuni, Michael Gatzen et autres

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HLA Heterozygosity Influences Colorectal Cancer Risk and Survival Outcome

Ya-Yu Tsai, Claire E. Thomas, Philip J. Law, Zhishan Chen et autres

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Germline HLA heterozygosity is associated with decreased lung cancer risk

Taotao Tan, Vikram R. Shaw, Jinyoung Byun, Hyun-Sung Lee et autres

Heterozygosity at human leukocyte antigen (HLA) loci may improve lung cancer immunosurveillance by increasing recognition of the tumor by the immune system. Previous studies utilizing data from population-level biobanks, such as the United Kingdom Biobank and FinnGen, have identified an association between …

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Genetic variation and regulation of MICA alters natural killer cell-mediated immunosurveillance in early-onset colorectal cancer.

Heather Michelle McGee, Joseph D. Bonner, Colt A. Egelston, Yubo Fu et autres

207 Background: One of the most concerning trends in oncology is the rapid increase in the incidence of early-onset cancers, such as colorectal cancer, in patients <50 years old. Patients with early-onset colorectal cancer (EO-CRC) often present with more advanced disease and …

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Chronic Disease Prevalence in Immigrants to Israel from the Former USSR

Rennert Gad, Luz Nurit, Ada Tamir, Yitzhak Peterburg

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