Mary Margaret Davis

Exercise as an Aging Mimetic: A New Perspective on the Mechanisms Behind Exercise as Preventive Medicine Against Age-Related Chronic Disease

Wesley K. Lefferts, Mary Margaret Davis, Rudy J. Valentine

Age-related chronic diseases are among the most common causes of mortality and account for a majority of global disease burden. Preventative lifestyle behaviors, such as regular exercise, play a critical role in attenuating chronic disease burden. However, the exact mechanism behind exercise …

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Exercise is aging: a new perspective on the mechanisms behind exercise as preventive medicine against age-related chronic disease

Mary Margaret Davis

Classic and “Dissecting” Gonadoblastoma in a Phenotypic Girl With a 46, XX Peripheral Karyotype and No Evidence of a Disorder of Sex Development

Lawrence Max Roth, Mary Margaret Davis, Bernard Czernobilsky

Herein, we report a case of a 9-yr-old girl who had a 46, XX peripheral karyotype and apparent developmentally normal ovaries. She presented with abdominal pain and a right adnexal mass. No clinical or pathologic evidence of gonadal dysgenesis or undifferentiated gonadal …

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Enchondroma Protuberans of the Ulna in a Pediatric Patient

Peter Lasater, Matthew R. Steensma, Cameron Patthanacharoenphon, Mary Margaret Davis

CASE: We report the case of a 3-year-old boy who presented with a distal ulnar fracture through a mixed sclerotic and lytic expansile lesion. The underlying lesion, an enchondroma protuberans, can mimic either benign or malignant bone tumors. It was successfully treated …

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Leptin decreases heart rate associated with increased ventricular repolarization via its receptor

Yen‐Chang Lin, Jianying Huang, Stan Hileman, Karen H. Martin et autres

Leptin has been proposed to modulate cardiac electrical properties via β-adrenergic receptor activation. The presence of leptin receptors and adipocytes in myocardium raised a question as to whether leptin can directly modulate cardiac electrical properties such as heart rate and QT interval …

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Surveillance after initial surgery for Stage I pediatric and adolescent boys with malignant testicular germ cell tumors: Report from the Children’s Oncology Group

Frederick J. Rescorla, Jonathan H. Ross, Deborah F. Billmire, Bryan J. Dicken et autres

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Novel FUS‐KLF17 and EWSR1‐KLF17 fusions in myoepithelial tumors

Shih‐Chiang Huang, Hsiao‐Wei Chen, Lei Zhang, Yun‐Shao Sung et autres

Myoepithelial (ME) tumors of soft tissue and bone display a heterogeneous histologic spectrum and in about half of the cases harbor EWSR1 gene rearrangements. Despite rare case reports, the prevalence of fused in sarcoma (FUS) gene abnormalities and its related fusion partners …

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Targeting receptor-activator of nuclear kappaB ligand in aneurysmal bone cysts: verification of target and therapeutic response

Dominic W. Pelle, Jonathan W. Ringler, Jacqueline D. Peacock, Kevin Kampfschulte et autres

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Surveillance After Initial Surgery for Pediatric and Adolescent Girls With Stage I Ovarian Germ Cell Tumors: Report From the Children's Oncology Group

Deborah F. Billmire, John W. Cullen, Frederick J. Rescorla, Mary Margaret Davis et autres

PURPOSE: To determine whether overall survival (OS) can be preserved for patients with stage I pediatric malignant ovarian germ cell tumor (MOGCT) with an initial strategy of surveillance after surgical resection. PATIENTS AND METHODS: Between November 2003 and July 2011, girls age …

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Clinical, histologic, and genetic features of mesothelioma in a 7‐Year‐old child

Aaron Sugalski, Mary Margaret Davis, Latha Prasannan, Victor A. Saldivar et autres

Malignant mesothelioma (MM) is a highly aggressive malignancy that is extremely rare in children. This case report documents a 7-year-old male without previous asbestos exposure with peritoneal MM that initially responded to chemotherapy with cisplatin and gemcitabine but ultimately metastasized to his …

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Gemistocytic Astrocytoma With PNET Tumor Arising Within a Mature Ovarian Teratoma and Seeding Metastasis in a Premenarchal Girl

Candice Fraiser, Monique M. Regard, Mehmet Fevzi Ozkaynak, Mary Margaret Davis

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Diffuse Lung Disease in Young Children

Gail H. Deutsch, Lisa R. Young, Robin R. Deterding, Leland L. Fan et autres

RATIONALE: Considerable confusion exists regarding nomenclature, classification, and management of pediatric diffuse lung diseases due to the relative rarity and differences in the spectrum of disease between adults and young children. OBJECTIVES: A multidisciplinary working group was formed to: (1) apply consensus …

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