Yusuke Nakamura

L-Carnitine has a liver-protective effect through inhibition of inducible nitric oxide synthase induction in primary cultured rat hepatocytes

Yusuke Nakamura, Hiroya Iida, Richi Nakatake, Tatsuma Sakaguchi et autres

Background: L-Carnitine has protective effects on various injured organs. However, it has not been reported whether L-carnitine influences the induction of inducible nitric oxide synthase (iNOS) expression during inflammation. Nitric oxide (NO) produced by iNOS is an inflammatory indicator in organs which …

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Cancer Precision Medicine; Where We Should Go?

Yusuke Nakamura

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Effect of a third-generation oncolytic herpes simplex virus on the growth of human hepatocellular carcinoma.

Richi Nakatake, Masaki Kaibori, Yusuke Nakamura, Hideyuki Matsushima et autres

321 Background: Multimodality therapies are used to manage patients with hepatocellular carcinoma (HCC), although advanced HCC is incurable. The third-generation oncolytic herpes simplex virus type 1 (HSV-1) T-01 replicates efficiently and selectively in tumor cells, kills tumor cells without damaging the surrounding …

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Stress evaluation method by pupil size for companion animals

Natsuki Uchida, Kato Ayako, Shimizu Kazuki, Yusuke Nakamura et autres

Third‐generation oncolytic herpes simplex virus inhibits the growth of liver tumors in mice

Richi Nakatake, Masaki Kaibori, Yusuke Nakamura, Yoshito Yannick Tanaka et autres

Multimodality therapies are used to manage patients with hepatocellular carcinoma (HCC), although advanced HCC is incurable. Oncolytic virus therapy is probably the next major breakthrough in cancer treatment. The third-generation oncolytic herpes simplex virus type 1 (HSV-1) T-01 kills tumor cells without …

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Sustained oligoclonal T cell expansion correlates with durable response to anti-PD1 therapy.

Sope Omowale Olugbile, Kazuma Kiyotani, Jae Hyeon Park, Philip C. Hoffman et autres

3061 Background: Immune checkpoint blockers have demonstrated durable response in many tumor types including lung cancer. This clinical benefit is however restricted to a subset of patients in whom longitudinal assessments of their tumor microenvironment have revealed increase CD8+ T cell infiltration. …

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Spontaneous rupture of a splenic abscess in a 2-year-old boy

Mai Okano, Tatsuma Sakaguchi, Kazuyoshi Nakatani, Hiroshi Hamada et autres

• A splenic abscess ruptured spontaneously during conservative treatment. • A surgical procedure for a splenic abscess should be considered at an early stage. • Bacteroides fragilis was isolated from the ascitic fluid.

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Abstract 1267: Identification and characterization of oncogenic methyltransferase ESOC1 as a diagnostic and therapeutic target for esophageal cancer

Yataro Daigo, Atsushi Takano, Yusuke Nakamura

Abstract Esophageal cancer is one of the most lethal malignancies of the digestive tract, and at the time of diagnosis most of the patients are at advanced stages. In spite of the use of current surgical techniques combined with various treatment modalities, …

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Abstract 3480: Germline PARP4 mutations in patients with primary thyroid and breast cancers

Yuji Ikeda, Kazuma Kiyotani, Poh Yin Yew, Taigo Kato et autres

Abstract Breast and thyroid cancers occur more frequently in the same individual than what is expected due to random occurrence, implying the presence of genetic susceptible factors. Germline mutations in the PTEN gene, which cause Cowden syndrome (CS), are known to be …

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T-LAK cell-originated protein kinase (TOPK) as a prognostic factor and a potential therapeutic target in ovarian cancer.

Yuji Ikeda, Jae Hyeon Park, Takashi Miyamoto, Naofumi Takamatsu et autres

e17091 Background: TOPK (T-lymphokine-activated killer cell-originated protein kinase) status in ovarian cancer is not well known. We aimed to clarify the clinical significance of TOPK expression in ovarian cancer and evaluate the possible effect of TOPK inhibitors, OTS514 and OTS964, on ovarian …

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Characterization of T-cell Receptor Repertoire in Inflamed Tissues of Patients with Crohnʼs Disease Through Deep Sequencing

Christopher G. Chapman, Rui Yamaguchi, Kenji Tamura, Jerome G. Weidner et autres

BACKGROUND: Intestinal tissues of patients with Crohn's disease (CD) contain expanded populations of T cells which are believed to mediate inflammation. We performed a detailed characterization of these T-cell repertoires. METHODS: We obtained biopsies from the neoterminal ileum of 12 patients undergoing …

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The current and future applications of immunopharmacogenomics.

Yusuke Nakamura

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