A. W. Dekker

Intensified chemotherapy inspired by a pediatric regimen combined with allogeneic transplantation in adult patients with acute lymphoblastic leukemia up to the age of 40

Anita W. Rijneveld, Bronno van der Holt, Simon M. G. J. Daenen, Bart J. Biemond et autres

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High Dose Intensive Chemotherapy, as Is Standard in Childhood Leukemia, Is Feasible and Efficacious in Adult Patients with Acute Lymphoblastic Leukemia (ALL) up to the Age of 40

Anita W. Rijneveld, Bronno van der Holt, Simon M.J.G. Daenen, Bart J. Biemond et autres

Treatment of Older Patients, 40 to 70 Years of Age, with Acute Lymphoblastic Leukemia According to a Chemotherapy Regimen That Includes a Novel Pre-Phase for Rapid Tumor Load Reduction. Results of the Dutch-Belgian HOVON-71 Study.

Simon M. G. J. Daenen, Bronno van der Holt, A. W. Dekker, Roelof Willemze et autres

Abstract Abstract 2028 Poster Board II-5 Background. Based on the dismal outcome of older patients with ALL and a promising pilot study in a single institution, HOVON started a multicenter phase 2 feasibility study to assess efficacy and safety of a novel …

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High Dose Intensive Chemotherapy, as Is Standard in Childhood Leukemia, Is Feasible and Efficacious in Adult Patients with Acute Lymphoblastic Leukemia (ALL) up to the Age of 40: Results From the Dutch-Belgian HOVON-70 Study.

Anita W. Rijneveld, Bronno van der Holt, Simon M. G. J. Daenen, Bart J. Biemond et autres

Abstract Abstract 323 Event-free survival (EFS) at 5 years in pediatric ALL is > 80% with dose intensive multi-agent chemotherapy. In contrast, adult ALL still has an unsatisfactory outcome, which may partly be due to less cumulative dosing of chemotherapeutic agents and …

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Erythropoietin synthesis is primarily regulated by the PHD2-HIF-2alpha-VHL axis as documented by HIF-2alpha associated familial erythrocytosis

Melanie J. Percy, Paul W. Furlow, Philip A. Beer, Gavin Campbell et autres

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Treatment of Primary CNS Lymphoma in the Elderly, a Multicenter Retrospective Analysis

Jacoline E. C. Bromberg, Jeanette Doorduyn, Macha Schuurmans, Philip M. Poortmans et autres

Abstract Patients with primary CNS lymphoma (PCNSL) are preferably treated with high-dose Methotrexate (HD-MTX)-based chemotherapy followed by consolidation radiotherapy in many centers. As elderly patients have an increased risk of complications with this approach, they are frequently treated with chemotherapy or radiotherapy …

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HIF-2alpha Associated Familial Erythrocytosis Supports the PHD2-HIF- 2alpha-VHL Axis as the Major Regulator of Erythropoietin Production

Melanie J. Percy, Paul W. Furlow, Philip A. Beer, Gavin Campbell et autres

Abstract Transcriptionally erythropoietin (Epo) synthesis is tightly regulated by the hypoxia inducible factor (HIF), which is composed of one alpha and one beta subunit that are constitutively expressed. The beta subunit is non-variable, but three different alpha subunits give rise to three …

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Myeloablative allogeneic versus autologous stem cell transplantation in adult patients with acute lymphoblastic leukemia in first remission: a prospective sibling donor versus no-donor comparison

Jan J. Cornelissen, Bronno van der Holt, Gregor E. G. Verhoef, Mars B. van ’t Veer et autres

While commonly accepted in poor-risk acute lymphoblastic leukemia (ALL), the role of allogeneic hematopoietic stem cell transplantation (allo-SCT) is still disputed in adult patients with standard-risk ALL. We evaluated outcome of patients with ALL in first complete remission (CR1), according to a …

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High acquisition and environmental contamination rates of CC17 ampicillin-resistant Enterococcus faecium in a Dutch hospital

Marieke J. A. de Regt, L. E. van der Wagen, Janetta Top, Hetty E. M. Blok et autres

BACKGROUND: Enterococcus faecium has rapidly emerged as a nosocomial pathogen worldwide, and the majority of these isolates belong to clonal complex-17 (CC17). In Europe, CC17 isolates are usually ampicillin-resistant, but most are still vancomycin-sensitive. We aimed to study ampicillin-resistant E. faecium (ARE) …

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Single-centre experience with nonmyeloablative allogeneic stem cell transplantation in patients with multiple myeloma: prolonged remissions induced.

Suzanne van Dorp, Ellen Meijer, Niels W.C.J. van de Donk, A. W. Dekker et autres

BACKGROUND: The role of allogeneic stem cell transplantation in multiple myeloma is not yet established. METHODS: We retrospectively evaluated the outcome of nonmyeloablative allogeneic stem cell transplantation (NMA) in patients with multiple myeloma treated at the Department of Haematology of the University …

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Phonology as human behavior

A. W. Dekker, Bob de Jonge

The authors analyze the distribution in the lexicon of nine Peninsular Spanish consonants (/p, t, k, b, d, g, f, ?, ?/) within the framework of Phonology as Human Behavior with respect to two hypothesised factors: Complexity of Articulation and Visibility. In …

Frequent Detection of Respiratory Viruses in Adult Recipients of Stem Cell Transplants with the Use of Real-Time Polymerase Chain Reaction, Compared with Viral Culture

Marian G.J. van Kraaij, Leontine J. R. van Elden, Anton M. van Loon, Karin A. W. Hendriksen et autres

BACKGROUND: Respiratory virus infections have been recognized as important causes of severe pneumonia in patients who have undergone stem cell transplantation (SCT). Reported incidences of respiratory virus infection in adult SCT recipients vary in the literature from 3.5% to 36% when determined …

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