Margaret Haugh

A trivalent, inactivated influenza vaccine (Vaxigrip®): summary of almost 50 years of experience and more than 1.8 billion doses distributed in over 120 countries

Margaret Haugh, Viviane Gresset-Bourgeois, Bérengère Macabeo, Anne Woods et autres

INTRODUCTION: Vaxigrip, a trivalent split-virion, inactivated vaccine available since 1968 has been in use longer than any other influenza vaccine. It is the most widely-used influenza vaccine, with more than 1.8 billion doses distributed in more than 120 countries. Areas covered: The …

fr (code pays fourni par la source)

The level of evidence for the use of biomarkers in the early detection of prostate cancer

Pierre‐Jean Lamy, Anne‐Sophie Gauchez, Laurent Salomon, Margaret Haugh et autres

To systematically review the evidence for the use of PSA and other biomarkers in the early detection of prostate cancer, we searched PubMed for clinical trials and studies assessing PSA and other biomarkers in the early detection of prostate cancer, published between …

fr, ca, mq (code pays fourni par la source)

Herpes zoster-associated mortality in Europe: a systematic review

Hélène Bricout, Margaret Haugh, Olugbenga Olatunde, Ruth Prieto

BACKGROUND: Reactivation of latent varicella zoster virus, partly due to age-related immunosenescence and immunosuppressive conditions, results in herpes zoster (HZ) and its associated complications. The management of the most important complication, post-herpetic neuralgia (PHN), is challenging, particularly in the elderly, and is …

fr, us, gb, es (code pays fourni par la source)

Comparison of an effect-model-law-based method versus traditional clinical practice guidelines for optimal treatment decision-making: application to statin treatment in the French population

Riad Kahoul, François Gueyffier, Emmanuel Amsallem, Margaret Haugh et autres

Healthcare authorities make difficult decisions about how to spend limited budgets for interventions that guarantee the best cost-efficacy ratio. We propose a novel approach for treatment decision-making, OMES-in French: Objectif thérapeutique Modèle Effet Seuil (in English: Therapeutic Objective-Threshold-Effect Model; TOTEM). This approach …

fr, cl (code pays fourni par la source)

Ki-67: level of evidence and methodological considerations for its role in the clinical management of breast cancer: analytical and critical review

Élisabeth Luporsi, Fabrice André, Frédérique Spyratos, Pierre‐Marie Martin et autres

Clinicians can use biomarkers to guide therapeutic decisions in estrogen receptor positive (ER+) breast cancer. One such biomarker is cellular proliferation as evaluated by Ki-67. This biomarker has been extensively studied and is easily assayed by histopathologists but it is not currently …

fr, ch (code pays fourni par la source)

Towards Personalized Medicine: Exploring the Consequences of the Effect Model-Based Approach

Jean‐Pierre Boissel, Riad Kahoul, Emmanuel Amsallem, François Gueyffier et autres

Although personalized medicine has been a subject of research and debate in recent years, it has been underused in medical practice, except in some cancers. We believe that the main reason for the gap between the potential of personalized medicine and its …

fr (code pays fourni par la source)

Factor Xa Inhibition: Correlation between the Plasma Levels of Anti-Xa Activity and Occurrence of Thrombosis and Haemorrhage

Alain Leizorovicz, L. Bara, M Samama, Margaret Haugh

A multicentre, double-blind, randomised trial was conducted to compare the efficacy of a low-molecular-weight (LMW) heparin, Logiparin, with that of an unfractionated (UF) heparin in the prophylactic treatment of thrombosis in patients undergoing general surgery. A total of 1,290 patients were randomised …

us, fr (code pays fourni par la source)

Heterogeneous Effect of Quinidine on the Ventricular Depolarization Process Assessed by the Spatial Velocity Electrocardiogram of the QRS Complex

Samir Fareh, P Arnaud, Jocelyne Fayn, Patrice Nony et autres

The negative conduction effect of quinidine on each of the successive phases of the ventricular depolarization was investigated using an original noninvasive method: the spatial velocity electrocardiogram of the QRS complex (SVECG-QRS). We performed a randomized placebo-controlled trial in 10 healthy subjects …

fr (code pays fourni par la source)

Evaluation of two evidence‐based knowledge transfer interventions for physicians. A cluster randomized controlled factorial design trial: the CardioDAS Study

Emmanuel Amsallem, Christelle Kasparian, Michel Cucherat, Sylvie Chabaud et autres

To investigate the potential benefits of two modes of evidence-based knowledge transfer ('active' and 'passive' modes) in terms of improvement of intention of prescription, knowledge, and real prescription in practice, we performed an open randomized controlled trial (CardioDAS) using a factorial design …

fr (code pays fourni par la source)

Adaptation of clinical guidelines: literature review and proposition for a framework and procedure

Bèatrice Fervers, Jako Burgers, Margaret Haugh, Jean Latreille et autres

PURPOSE: The development and updating of high-quality clinical practice guidelines require substantial resources. Many guideline programmes throughout the world are using similar strategies to achieve similar goals, resulting in many guidelines on the same topic. One method of using resources more efficiently …

ch (code pays fourni par la source)

Predictors of high quality clinical practice guidelines: examples in oncology

Bèatrice Fervers, Jako Burgers, Margaret Haugh, Melissa Brouwers et autres

OBJECTIVE: Clinical practice guidelines are widely used as effective tools for improving the management of patients with cancer. However, there is increasing concern about variation in guideline quality. In this study we identified predictors for high-quality guidelines in oncology. DESIGN: The quality …

fr (code pays fourni par la source)

Bridging the gap between therapeutic research results and physician prescribing decisions: knowledge transfer, a prerequisite to knowledge translation

Jean‐Pierre Boissel, Emmanuel Amsallem, Michel Cucherat, Patrice Nony et autres