Joseph C.K. Leung

FC 119: Kidney-Specific Silencing of Neat1 Alleviates Diabetic Kidney Injury

Rui Xue, Wai Han Yiu, Joseph C.K. Leung, Loretta Y.Y. Chan et autres

Abstract BACKGROUND AND AIMS Long noncoding RNA Nuclear Enriched Abundant Transcript 1 (Neat1) not only serves as a key structural component of nuclear paraspeckle, but is also involved in a variety of pathophysiological processes. Our previous study shows that increased Neat1 expression …

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Patients’ and clinicians’ expectations on integrative medicine Services for Diabetes: a focus group study

Kam Wa Chan, Pak Wing Lee, Crystal Pui Sha Leung, Gary C.W. Chan et autres

BACKGROUND: Difference of perspective between patients and physicians over integrative medicine (IM) research and service provision remains unclear despite significant use worldwide. We observed an exceptionally low utilisation of IM and potential underreporting in diabetes. We aimed to explore the barriers and …

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P1045MISALIGNED EXPECTATIONS ON INTEGRATIVE MEDICAL SERVICE FOR DIABETES AND DIABETIC KIDNEY DISEASE: A COMPARATIVE FOCUS GROUP SERIES OF PATIENTS AND PHYSICIANS

Kam Wa Chan, Pak Wing Lee, Crystal Pui Sha Leung, Gary C.W. Chan et autres

Abstract Background and Aims Difference of perspective between patients and physicians over integrative medicine (IM) research and service provision remains unclear despite significant use worldwide. We sought to explore the barriers and recommendations regarding IM service among diabetes and diabetic kidney disease …

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Semi-individualised Chinese medicine treatment as an adjuvant management for diabetic nephropathy: a pilot add-on, randomised, controlled, multicentre, open-label pragmatic clinical trial

Kam Wa Chan, Tai‐Pang Ip, Alfred Siu Kei Kwong, Sing Leung Lui et autres

INTRODUCTION: Diabetes mellitus and diabetic nephropathy (DN) are prevalent and costly to manage. DN is the leading cause of end-stage kidney disease. Conventional therapy blocking the renin-angiotensin system has only achieved limited effect in preserving renal function. Recent observational data show that …

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Effect of Subcutaneous and Intraperitoneal Administration of Recombinant Human Erythropoietin on Blood Pressure and Vasoactive Hormones in Patients on Continuous Ambulatory Peritoneal Dialysis

Kar Neng Lai, Siu Fai Lui, Joseph C.K. Leung, Eric Law et autres

The effect of subcutaneous and intraperitoneal administration of recombinant human erythropoietin (rHuEPO) on blood pressure was evaluated in 20 patients with renal failure on continuous ambulatory peritoneal dialysis. The two groups of patients were commenced on a 16-week course of twice weekly …

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Charge-dependent binding of polymeric IgA1 to human mesangial cells in IgA nephropathy

Joseph C.K. Leung, Sydney C.W. Tang, Man Fai Lam, Tak Mao Chan et autres

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Interleukin-5 messenger RNA expression in peripheral blood CD4+ cells in asthma

Christopher K. W. Lai, Alice Ho, Christopher H.S. Chan, Janet Tang et autres

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Increased binding of polymeric λ-IgA to cultured human mesangial cells in IgA nephropathy

Kar Neng Lai, Wah Yuen To, Philip Kam‐Tao Li, Joseph C.K. Leung

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Biliary IgA secretion in obstructive jaundice: The effects of endoscopic drainage

Joseph J.�Y. Sung, Joseph C.K. Leung, CP Tsui, S. C. S. Chung et autres

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Serum Concentration of Soluble Interleukin 2 Receptors in Asthma

Christopher K. W. Lai, Christopher H.S. Chan, Joseph C.K. Leung, Kar Neng Lai

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Cytokine production by peripheral blood mononuclear cells in IgA nephropathy

Kar Neng Lai, Joseph C.K. Leung, P. K.-T. Li, Siu Fai Lui

The regulation of cytokine production and T cell proliferation by other cytokines is mandatory in mediating inflammatory responses but the full understanding is far from complete. We have previously reported increased production of IL-2 and IL-2 receptors (IL-2R) in IgA nephropathy. The …

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In vitro study of expression of interleukin-2 receptors in T-lymphocytes from patients with IgA nephropathy.

Kar Neng Lai, Joseph C.K. Leung, F M Lai

The present study was undertaken to examine the expression of interleukin-2 receptor (IL-2R)/CD25 antigen in cultured T-lymphocyte subsets in IgA nephropathy. Twenty-four IgA nephritic patients, 12 patients with chronic glomerulonephritis (non-IgA nephropathy), and 17 healthy controls were studied in an infection-free interval. …

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