Huseyin Mehmet

Supplementary Figures 1-2 from The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

Kristel Kemper, Martin Ronald Sprick, Martijn de Bree, Alessandro Scopelliti et autres

Supplementary Figures 1-2 from The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

Supplementary Figure Legends 1-2 from The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

Kristel Kemper, Martin Ronald Sprick, Martijn de Bree, Alessandro Scopelliti et autres

Supplementary Figure Legends 1-2 from The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

Supplementary Figures 1-2 from The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

Kristel Kemper, Martin Ronald Sprick, Martijn de Bree, Alessandro Scopelliti et autres

Supplementary Figures 1-2 from The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

Supplementary Figure Legends 1-2 from The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

Kristel Kemper, Martin Ronald Sprick, Martijn de Bree, Alessandro Scopelliti et autres

Supplementary Figure Legends 1-2 from The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

Data from The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

Kristel Kemper, Martin Ronald Sprick, Martijn de Bree, Alessandro Scopelliti et autres

Abstract Colon cancer stem cells (CSC) can be identified with AC133, an antibody that detects an epitope on CD133. However, recent evidence suggests that expression of CD133 is not restricted to CSCs, but is also expressed on differentiated tumor cells. Intriguingly, we …

Data from The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation

Kristel Kemper, Martin Ronald Sprick, Martijn de Bree, Alessandro Scopelliti et autres

Abstract Colon cancer stem cells (CSC) can be identified with AC133, an antibody that detects an epitope on CD133. However, recent evidence suggests that expression of CD133 is not restricted to CSCs, but is also expressed on differentiated tumor cells. Intriguingly, we …

Late-Onset Pharmacological or Dietary Interventions Improve Healthspan and Lifespan in Male and Female Mice

Sarah Jayne Mitchell, Michael Robert MacArthur, Alice E. Kane, Margaret E. Torrence et autres

Abstract While late-onset dietary or pharmacological interventions can extend longevity in rodents, whether or not they can be used to reverse or forestall onset of aging-related symptoms (i.e. frailty) remains untested. Here, we employed three interventions to test this hypothesis. Male and …

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Longevity-Extending MetAP2 Inhibitors Induce Caloric Restriction Through P53-Dependent Induction of GDF-15

Michael Robert MacArthur, Sarah Jayne Mitchell, Jon Jung, Margaret E. Torrence et autres

Abstract MetAP2 is a 67kDa protein which sits at the translation initiation complex and cleaves N-terminal methionine off of nascent peptides. Inhibitors of MetAP2 cause profound weight loss secondary to decreased food intake. These inhibitors also significantly extend longevity in mice in …

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Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia

Faisal Ahmad Al-Allaf, Zainularifeen Abduljaleel, Mohammad Athar, Mohiuddin M. Taher et autres

Internal ribosome entry site (IRES) sequences have become a valuable tool in the construction of gene transfer and therapeutic vectors for multi-cistronic gene expression from a single mRNA transcript. The optimal conditions for effective use of this sequence to construct a functional …

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Fas-ligand and interleukin-6 in the cerebrospinal fluid are early predictors of hypoxic-ischemic encephalopathy and long-term outcomes after birth asphyxia in term infants

Kristín Leifsdóttir, Huseyin Mehmet, Staffan Eksborg, Eric Herlenius

BACKGROUND: Cerebral ischemia generates neuroinflammation that can induce neural cell death. This cohort study assessed whether Fas-ligand (FasL) and interleukin (IL)-6 levels in the cerebrospinal fluid (CSF) after hypoxic-ischemic encephalopathy (HIE) can serve as biomarkers of hypoxic brain injury in neonates. METHODS: …

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Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity

Yanxia Guo, Kenzie D. MacIsaac, Yi Chen, Richard J. Miller et autres

Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation of Th17 differentiation and function. RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival of CD4 + CD8 + (DP) thymocytes. While RORγ antagonists are currently …

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TLR4, TLR7/8 agonist-induced miR-146a promotes macrophage tolerance to MyD88-dependent TLR agonists

Md A. Nahid, L Benso, John D. Shin, Huseyin Mehmet et autres

TLRs facilitate the recognition of pathogens by immune cells and the initiation of the immune response, leading to the production of proinflammatory cytokines and chemokines. Production of proinflammatory mediators by innate immune cells, such as macrophages, is tightly regulated to facilitate pathogen …

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