Mital N. Patel

DINOcell: learning generalizable perturbation effects through self-distillation

J Li, Nilgun Tasdemir, Sofia Kyriazopoulou Panagiotopoulou, Sophie Xu et autres

A bstract Predicting cellular responses to therapeutics is a promising approach for novel target discovery. However, state-of-the-art computational models designed to predict perturbation effects struggle to generalize and outperform simple baselines. We present DINOcell, a weakly supervised framework that adapts self-distillation to …

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1125 gx1: virtual target identification for overcoming T cell exhaustion

Amaro N Taylor-Weiner, Sofia Kyriazopoulou Panagiotopoulou, Ashley A. Cass, David DeTomaso et autres

Background AI models have been developed to better understand disease through histology or protein structure, however these tools cannot model the impact of therapeutics on disease in a cellular context. AI cell models could simulate cellular responses to therapeutics, enabling exploration of …

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The Promising Potential of Optical Nanosensors in Healthcare

Priyanka S. Prabhu, Anuj Nahata, Mital N. Patel

Nanotechnology has been applied to the field of optical sensors to enhance their sensitivity and specificity, decrease response time, and enable multiplex sensing. Optical nanosensors fabricated using organic, inorganic, carbon-based materials and composites have been explored. Different types of optical nanosensors include …

Harnessing the power of artificial intelligence (AI) for insights into FDA recall patterns: a retrospective analysis

Sahil Jamil Mulla, Mital N. Patel

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Sustainable Stability Analysis of Vibegron: A Novel Chromatographic Method Development and Validation

Nidhi Vadnere, Mital N. Patel

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Comprehensive LC-MS/MS profiling, toxicity assessment, and molecular docking analysis of Vibegron degradation products

Nidhi Vadnere, Rajasekhar Reddy Alavala, Mital N. Patel

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Sustainability assessment of PDE-5 inhibitor analysis: A comparative study using AGREE, AGREEPrep, Complex GAPI, and BAGI

Jeswin Maliyakal, Nidhi Vadnere, Sandesh Bherje, Mital N. Patel

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UV spectrophotometry and HPLC quantification of vibegron: evaluating whiteness, greenness, and blueness

Nidhi Vadnere, Mital N. Patel

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Global Regulatory Perspectives on Sensor-Enabled and Biomaterial-Integrated Medical Devices: A Focus on India, Canada, and Australia

Sahil Jamil Mulla, Mital N. Patel

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Integrating Quality by Design and Green Chemistry for Sustainable Drug Development: Acalabrutinib Stability Study

Anuj N. Nahata, Himanshu Pawar, Mital N. Patel

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Green chemistry approaches in the analytical validation of fosravuconazole using UV spectrophotometry and HPLC

Jeswin Maliyakal, Mital N. Patel

• This study addresses the need for a precise quantitative method to determine Fosravuconazole and developed validated analytical methods using UV spectrophotometry and High-Performance Liquid Chromatography (HPLC). • Both methods were rigorously validated according to ICH Q2(R1) guidelines, demonstrating their suitability for …

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Towards Sustainable Urban Living: Assessing Social Sustainability in the Saurashtra Region of Gujarat, India

Mital N. Patel, Shashikant Kumar, Anand Achari

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