Alvin Lo

Unraveling Tyrosine-Kinase Inhibitor Resistance in NSCLC Cells via Same-cell Measurement of RNA, Protein, and Morphological Responses

Vivian T. Dien, Connor Thompson, Tristin Rammel, Jaime Roquero et autres

Abstract Non-small cell lung cancer (NSCLC) frequently develops resistance to tyrosine kinase inhibitors (TKIs), limiting the long-term success of targeted therapies. A deeper understanding of resistance mechanisms at the molecular and cellular levels may enable the development of more effective treatment strategies. …

Identification of genetic loci that control mammary tumor susceptibility through the host microenvironment

Pengju Zhang, Alvin Lo, Yurong Huang, Ge Huang et autres

The interplay between host genetics, tumor microenvironment and environmental exposure in cancer susceptibility remains poorly understood. Here we assessed the genetic control of stromal mediation of mammary tumor susceptibility to low dose ionizing radiation (LDIR) using backcrossed F1 into BALB/c (F1Bx) between …

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Characterization of the Stromal and Epithelial Pathways in the Mammary Gland causing Susceptibility to Cancer

Alvin Lo

Author(s): Lo, Alvin Tu | Advisor(s): Bissell, Mina J; Liu, Fenyong | Abstract: It is now known, the microenvironment including the stroma play an important role in both organ specificity and mammary cancer. In characterizing the interactions between stroma and epithelium, it …

An interferon signature identified by RNA-sequencing of mammary tissues varies across the estrous cycle and is predictive of metastasis-free survival

Antoine M. Snijders, Sasha A. Langley, Jian‐Hua Mao, Sandhya Bhatnagar et autres

// Antoine M. Snijders 1 , Sasha Langley 1 , Jian-Hua Mao 1 , Sandhya Bhatnagar 1 , Kathleen A. Bjornstad 1 , Chris J. Rosen 1 , Alvin Lo 1 , Yurong Huang 1 , Eleanor A. Blakely 1 , Gary …

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Epimorphin Is a Novel Regulator of the Progesterone Receptor Isoform-A

Jamie L. Bascom, Derek C. Radisky, Yi Ling Eileen Koh, Jimmie E. Fata et autres

Epimorphin/syntaxin-2 is a membrane-tethered protein localized extracellularly (Epim) and intracellularly (Stx-2). The extracellular form Epim stimulates morphogenic processes in a range of tissues, including in murine mammary glands where its overexpression in luminal epithelial cells is sufficient to drive hyperplasia and neoplasia. …

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Patterned Collagen Fibers Orient Branching Mammary Epithelium through Distinct Signaling Modules

Douglas Brownfield, Gautham Venugopalan, Alvin Lo, Hidetoshi Mori et autres

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Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1

Hidetoshi Mori, Alvin Lo, Jamie L. Inman, Jordi Alcaraz et autres

Epithelial cell invasion through the extracellular matrix (ECM) is a crucial step in branching morphogenesis. The mechanisms by which the mammary epithelium integrates cues from the ECM with intracellular signaling in order to coordinate invasion through the stroma to make the mammary …

Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1

Hidetoshi Mori, Alvin Lo, Jamie L. Inman, Jordi Alcaraz et autres

Epithelial cell invasion through the extracellular matrix (ECM) is a crucial step in branching morphogenesis. The mechanisms by which the mammary epithelium integrates cues from the ECM with intracellular signaling in order to coordinate invasion through the stroma to make the mammary …

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Constructing Three-Dimensional Models to Study Mammary Gland Branching Morphogenesis and Functional Differentiation

Alvin Lo, Hidetoshi Mori, Joni D. Mott, Mina J. Bissell

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Abstract SY02-02: Interaction of MMPs with oncogenic signaling: Disruption of dynamic reciprocity and tissue polarity

Alain Béliveau, Joni D. Mott, Alvin Lo, Emily Chen et autres

Abstract Whether or not epithelial cells organize into three-dimensional structures defines their normal or invasive and malignant status. In a model of human breast morphogenesis, we have shown that inhibiting key signaling pathways in breast cancer cells leads to phenotypic reversion of …

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Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo

Alain Béliveau, Joni D. Mott, Alvin Lo, Emily I. Chen et autres

Organization into polarized three-dimensional structures defines whether epithelial cells are normal or malignant. In a model of morphogenesis, we show that inhibiting key signaling pathways in human breast cancer cells leads to "phenotypic reversion" of the malignant cells. Using architecture as an …

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HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment

Britta Weigelt, Alvin Lo, Catherine C. Park, Joe W. Gray et autres

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