Xinyu Zhu

Gut dysbiosis and jejunal injury in olfactory dysfunction: Experimental characterization and genetic epidemiological evidence

Xinyu Zhu, Jiao Zhou, Qi Li, Jiang Yao et autres

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Perinatal bisphenols combined exposure caused working memory impairment by disturbing the ventral hippocampus-medial prefrontal cortex circuit

Ningning Lin, Zimu Li, Lun Zhang, Huiping Tang et autres

Bisphenols (BPs), ubiquitous in food packaging, medical, and personal care products, are pervasive environmental contaminants. As bisphenol A (BPA) is increasingly replaced by its alternatives, the risk of mixed exposure and its impact on critical cognitive functions, such as working memory, remains …

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KCTD1 stabilizes c-Myc to upregulate PD-L1 and suppress anti-tumor immunity in hepatocellular carcinoma

Dongmei Zhong, Shengwen Long, Yilan Dai, Yaru Yin et autres

Hepatocellular carcinoma (HCC) is the predominant histologic subtype of primary liver cancer and accounts for approximately 90% of cases worldwide. Although immune checkpoint blockade (ICB) therapies targeting the PD-1/PD-L1 axis have demonstrated clinical promise in advanced HCC, therapeutic responses remain heterogeneous, underscoring …

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SULF1 and EPB41L3: Potential Biomarkers of Acute Myocardial Infarction and the Vascular Inflammatory Milieu

Houyong Zhu, Xiaoqun Xu, Xinyu Zhu, Jinyu Huang et autres

Background and Objective: Coronary endothelial dysfunction is considered one of the key pathological components in acute myocardial infarction (AMI). This study aimed to explore the expression patterns and potential significance of the differentially expressed genes SULF1 and EPB41L3 in AMI by integrating …

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Semi‐Continuous Versus Continuous Suturing Techniques in Bronchial Anastomosis Following da Vinci Robotic‐Assisted Sleeve Lobectomy

Zhiqiao Chen, Yongxin Fan, Xinyu Zhu, Shuyuan Li et autres

BACKGROUND: In robot-assisted thoracoscopic (RATS) bronchial sleeve lobectomy, despite the continuous suturing (CS) technique's widespread adoption, the safety and advantages of the semi-continuous suturing (SCS) technique remain inconclusive. METHODS: Patients undergoing RATS bronchial sleeve lobectomy for central Non-Small Cell Lung Cancer (NSCLC) …

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Target fishing: from “needle in haystack” to “precise guidance”--new technology, new strategy and new opportunity

Juan Chen, Yafei Guo, Jing Shao, Mei Guo et autres

Drug target discovery is the core breakthrough point of new drug research and development. The chemical complexity and biological network regulation characteristics of natural product systems with a long history of clinical application pose a challenge to the traditional single-target research paradigm. …

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Discovery of a novel napabucasin derivative B16 as a potent STAT3 inhibitor for the treatment of triple-negative breast cancer

Xu Deng, Yao Li, Ling Chen, Yuanzhu Xie et autres

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The She Economy in the New Media Era: Spatial Practice, Women's Mobility Reconstruction and Its Impact on Urban Employment and Industrial Development

Xinyu Zhu

This paper employs mobility as its core analytical lens to investigate how the "She Economy" in China's digital era reshapes consumer discipline, reconfigures female representation, professions, and spatial mobility, and drives urban economic and industrial transformation. However, new media platforms have emerged …

[Optimization of the Bombyx mori baculovirus expression system enhances the expression level of recombinant human keratinocyte growth factor-1 (hKGF-1)].

Shuo Li, Xingyang Wang, Xiaofeng Wu, Yanqiao Xu et autres

cells, establishing an ideal technological platform for the industrial utilization of recombinant hKGF-1. The developed methodology not only provides valuable technical references for the production of other growth factors and complex proteins, but also demonstrates significant implications for employing silkworms as bioreactors …

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An interpretable machine learning model for predicting bone marrow invasion in patients with lymphoma via 18F-FDG PET/CT: a multicenter study

Xinyu Zhu, Denglu Lu, Yang Wu, Yuan Lü et autres

Accurate identification of bone marrow invasion (BMI) is critical for determining the prognosis of and treatment strategies for lymphoma. Although bone marrow biopsy (BMB) is the current gold standard, its invasive nature and sampling errors highlight the necessity for noninvasive alternatives. We …

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Microcontroller Unit ESD-Induced Soft Failure Study

Yipeng Chen, Xinyu Zhu, Shipeng Chen, Ling Zhang et autres

Soft failures caused by system-level electrostatic discharges(ESD) can lead to functional abnormalities of chips in practical applications and have become one of the important forms of chip failures. However, there has always been a lack of a test method that can measure …

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Discovery of a Novel Silybin Derivative for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis

Zhongtai Sui, Mo Li, Xueyi Wang, Cailin Luo et autres

MASH has become the leading cause of liver disease worldwide, and the prevalence of MASH is steadily increasing. The development of new drugs for the treatment of MASH is urgent. Silybin has been used for decades in liver protection, but its insufficient …

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