Yunyun Jiang

Health and economic effects of increased taxation on tobacco, alcohol, and sugar-sweetened beverages in China: a modelling study

Tiange Chen, Jinyi Zhu, Sian Hsiang‐Te Tsuei, Yunyun Jiang et autres

BACKGROUND: China faces substantial burdens from tobacco, alcohol, and sugar-sweetened beverage (SSB) consumption, yet tax increases on these products have been stagnant. Existing evidence on the health, economic, and fiscal effects of such taxes in China is limited, which hinders tax reforms …

cn, us, ca (code pays fourni par la source)

Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinical trial

Hiddo J.L. Heerspink, José Cardona, Shivinder Jolly, Pablo E. Pérgola et autres

nl, us, pl, es, fi, it, gb (code pays fourni par la source)

#1585 Design and baseline characteristics of MIRO-CKD: a phase IIb, randomised, double-blind clinical trial to evaluate effects of balcinrenone in combination with dapagliflozin vs. dapagliflozin in patients with CKD

Patrick B. Mark, Erika De Sousa Amorim, Anna Eriksson, Nicolás Guzmán et autres

Abstract Background and Aims Despite clinical benefits of sodium glucose co-transporter-2 inhibitors (SGLT2i), recommended by current guidelines for the treatment of chronic kidney disease (CKD), there is still an unmet need for managing residual risk of disease progression. Balcinrenone is a novel …

pl, es, fi, us, nl (code pays fourni par la source)

Efficacy and Safety of Balcinrenone in Combination with Dapagliflozin on Albuminuria in Participants with CKD

Hiddo Jan L. Heerspink, José F. Cardona, Shivinder Jolly, Pablo E. Pérgola et autres

Background: SGLT2is reduce albuminuria and the risk of CKD progression, and the MRA finerenone has similar effects in T2D with CKD. We assessed the albuminuria-lowering efficacy and safety of the novel MRA balcinrenone combined with the SGLT2i dapagliflozin. Methods: In this double-blind, …

nl, us, ca, pl, es, se, it, br, gb (code pays fourni par la source)

Coptisine alleviates high glucose-induced HUVEC dysfunction in vitro and inhibits gestational diabetes mellitus in vivo

Lan Wang, Wei Xiong, Yunyun Jiang

cn (code pays fourni par la source)

Impact of Dapagliflozin on Cardiometabolic Outcomes After Acute Myocardial Infarction According to Baseline Glycemic Status and Body Mass Index: Subanalyses of the DAPA‐MI Trial

Robert F. Storey, John Deanfield, Stefan James, Ramzi Ajjan et autres

Background Dapagliflozin improved cardiometabolic outcomes following myocardial infarction in patients without prior type‐2 diabetes (T2DM) in the DAPA‐MI (dapagliflozin in patients with myocardial infarction) trial. The effect of glycemic status and body mass index (BMI) post–myocardial infarction requires elucidation. Methods Participants with …

gb, se, us, au, br, pl, es, fi (code pays fourni par la source)

Efficacy and safety of balcinrenone and dapagliflozin for CKD: design and baseline characteristics of the MIRO-CKD trial

Patrick B. Mark, Erika De Sousa‐Amorim, Anna L. Eriksson, Maria Leonsson‐Zachrisson et autres

BACKGROUND AND HYPOTHESIS: Despite benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) being recommended for treatment of chronic kidney disease (CKD), there is still an unmet need for managing renal residual risk. Based on pre-clinical data, balcinrenone is a novel mineralocorticoid receptor antagonist …

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Correction to “Systematical Mutational Analysis of FRATtide against Osteoclast Differentiation by Alanine Scanning”

Yi Yang, Chenchen Geng, Huaxing Shen, Jingru Chao et autres

[This corrects the article DOI: 10.1021/acsmedchemlett.4c00127.].

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A Phase 2b Dose-Finding Study to Evaluate Effects of Balcinrenone/Dapagliflozin vs. Dapagliflozin in Patients with CKD and Albuminuria

Patrick B. Mark, Anna Eriksson, Nicolás Guzmán, Maria Leonsson Zachrisson et autres

Background: Despite current standard of care with SGLT2i being recommended for the treatment of chronic kidney disease (CKD), there is still an unmet need for managing residual risk of disease progression. Balcinrenone is a novel selective mineralocorticoid receptor (MR) modulator, expected to …

gb, fi, es, us, se, nl (code pays fourni par la source)

Systematical Mutational Analysis of FRATtide against Osteoclast Differentiation by Alanine Scanning

Yi Yang, Chenchen Geng, Huaxing Shen, Jingru Chao et autres

Osteoporosis, a global bone disease, results in decreased bone density, mass, and microarchitecture deterioration, increasing fracture risk. In previous research, FRATtide, a peptide derived from a glycogen synthase kinase-3 binding protein, effectively hindered osteoclast differentiation to yield therapeutically potent derivatives via single …

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Systematic alanine and stapling mutational analysis of antimicrobial peptide Chem-KVL

Borui Zhen, Chenchen Geng, Yi Yang, Haiyan Liang et autres

Chem-KVL is a tandem repeating peptide, with 14 amino acids that was modified based on a short peptide from a fragment of the human host defense protein chemerin. Chem-KVL increases cationicity and hydrophobicity and shows broad-spectrum antibacterial activity. To determine the molecular …

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Economic optimization of fresh logistics pick-up routing problems with time windows based on gray prediction

Yonghong Liang, Xianlong Ge, Yuanzhi Jin, Zhong Zheng et autres

The rapid development of modern cold chain logistics technology has greatly expanded the sales market of agricultural products in rural areas. However, due to the uncertainty of agricultural product harvesting, relying on the experience values provided by farmers for vehicle scheduling can …

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