Yuge Wang

Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy by modulating the MeCP2/NLGN1 pathway

Bowen Hu, Yuge Wang, Ying Yang, Hua Wei et autres

PURPOSE: Sepsis-associated encephalopathy (SAE) is a common and serious complication in septic patients that significantly reduces quality of life. Besides its sedative and analgesic effects, dexmedetomidine has been suggested to have potential neuroprotective benefits. This study aims to determine whether dexmedetomidine guards …

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Adherence to the Dietary Index for Gut Microbiota and reduced risk of nephrolithiasis: a case–control study of Chinese adults

Xing Jin, Jia Li, Yuanqi Zhao, Kun Xu et autres

Objective: Nephrolithiasis represents a substantial clinical burden worldwide. The Dietary Index for Gut Microbiota (DI-GM) assesses dietary impacts on gut microbiota. However, its association with the risk of nephrolithiasis remains unclear in Chinese adults. Methods: We conducted a case-control study using the …

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Healthy Lifestyle, Genetic Susceptibility and Risk of Kidney Stone Disease in the UK Biobank: A Prospective Cohort Study

Kun Xu, Zichuan Yao, Yuge Wang, Lei Na et autres

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Meningeal lymphatics orchestrate vertebral neutrophils via a Hex1Cer-NETs axis to promote autoimmune neuroinflammation

Wenxuan Sun, Hanzhang Tan, Shishi Shen, Li Xiao et autres

Abstract Meningeal enhancement is observed on cranial and spinal magnetic resonance image in a subset of patients with multiple sclerosis (MS) and is associated with a higher risk of future disease progression, however, the underlying mechanisms by which it promotes such progression …

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Gastrointestinal dysfunction associated with autoimmune glial fibrillary acidic protein astrocytopathy

Li Xiao, Bing Qin, Yuefei Guo, Ping Zhang et autres

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Multifunctional dual drug-loaded Gel-Alg/MINO/MEL composite hydrogel for combating three-dimensional multi-species biofilm and experimental periodontitis treatment

Yuqing Yang, Yuge Wang, Min Zhi, Yixuan Wang et autres

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Data on Flash Flood Simulation and Runoff Generation Mechanisms in the Shewei River Basin

Yuge Wang, Xiekang Wang

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Data on Flash Flood Simulation and Runoff Generation Mechanisms in the Shewei River Basin

Yuge Wang, Xiekang Wang

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Identification of Conserved Cross-Reactive B-Cell Epitopes in CPV1 and CPV2 L1 Proteins with Vaccine Potential

Yuge Wang, Yingyi Chen, Kaixin Wang, Youqing Yuan et autres

Background/Objectives: Canine papillomavirus (CPV) is an important viral pathogen associated with papillomatosis in dogs, with canine papillomavirus type 1 (CPV1) and type 2 (CPV2) among the most prevalent and clinically relevant genotypes. The L1 capsid protein is a major immunogenic antigen of …

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Hypoxic preconditioning drives metabolic reprogramming to increase the therapeutic efficacy of adipose mesenchymal stem cells in diabetic wounds

Haiyue Ren, Hankun Cao, Cai He, Qiqi Zhang et autres

BACKGROUND: Hypoxic pretreatment improves the efficacy of adipose-derived mesenchymal stem cells (ADSCs) in the repair of chronic refractory wounds; however, the underlying molecular mechanisms remain poorly understood. Energy metabolism serves as a crucial regulatory factor that influences stem cell fate, proliferation, and …

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Establishment of a passive-transfer mouse model of anti-NMDAR encephalitis and delineation of the PI3K-AKT-HIF-1α Axis in antibody-induced neuronal injury

Huilu Li, S Y Zhang, Yaqing Shu, Yipeng Zhao et autres

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A crRNA/Cas12a complex-driven rapid and visual detection method for four porcine diarrhea viruses

Lei Lei, Lei Tan, Yingjie Chen, Xiaoye Peng et autres

BACKGROUND: Porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), porcine delta-coronavirus (PDCoV), and porcine rotavirus-A (PoRV) G9 are major swine pathogens primarily responsible for gastrointestinal diseases, particularly affecting lactating piglets and resulting in significant economic losses, especially in China. This study …

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