Ana Asenjo‐Bueno

Corrigendum to “Aging-related hyperphosphatemia triggers the release of TNF-α from macrophages, promoting indicators of sarcopenia through the reduction of IL-15 expression in skeletal muscle” [Life Sci. 368 (2025) 123507]

Elena Alcalde‐Estévez, Ariadna Moreno-Piedra, Ana Asenjo‐Bueno, María Martos-Elvira et autres

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Aging-related hyperphosphatemia triggers the release of TNF-α from macrophages, promoting indicators of sarcopenia through the reduction of IL-15 expression in skeletal muscle

Elena Alcalde‐Estévez, Ariadna Moreno-Piedra, Ana Asenjo‐Bueno, María Martos-Elvira et autres

AIMS: The association between aging-related hyperphosphatemia and sarcopenia has been documented, and evidence suggests that inflammaging is involved in the manifestation of sarcopenia. The present study investigates whether hyperphosphatemia triggers inflammation, thereby inducing the appearance of sarcopenia along with the cytokines involved …

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Integrin-Linked Kinase (ILK) Promotes Mitochondrial Dysfunction by Decreasing CPT1A Expression in a Folic Acid-Based Model of Kidney Disease

Mariano de la Serna-Soto, Laura Calleros, María Martos-Elvira, Ariadna Moreno-Piedra et autres

Integrin-linked kinase (ILK) is a key scaffolding protein between extracellular matrix protein and the cytoskeleton and has been implicated previously in the pathogenesis of renal damage. However, its involvement in renal mitochondrial dysfunction remains to be elucidated. We studied the role of …

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Respiratory dysfunction in old mice could be related to inflammation and lung fibrosis induced by hyperphosphatemia

Ana Asenjo‐Bueno, Elena Alcalde‐Estévez, Gemma Olmos, Patricia Martínez‐Miguel et autres

BACKGROUND: With age, lungs undergo typical changes that lead to a deterioration of respiratory function. Our aim was to assess the role of age-associated hyperphosphatemia in these changes. METHODS: We used C57BL6 mice to study an ageing model in vivo and human …

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Dietary phosphate restriction prevents the appearance of sarcopenia signs in old mice

Elena Alcalde‐Estévez, Patricia Sosa, Ana Asenjo‐Bueno, Patricia Plaza et autres

BACKGROUND: Sarcopenia is defined by the progressive and generalized loss of muscle mass and function associated with aging. We have previously proposed that aging-related hyperphosphataemia is linked with the appearance of sarcopenia signs. Because there are not effective treatments to prevent sarcopenia, …

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MO414: Sucroferric Oxyhydroxide (Velphoro®) Treatment Mitigates the Signs of Ageing-Related Sarcopaenia in Old Mice

Elena Alcalde‐Estévez, Ana Asenjo‐Bueno, Patricia Sosa, Patricia Plaza et autres

Abstract BACKGROUND AND AIMS Sarcopaenia, defined as the loss of muscle mass and function, is an ageing-related pathology associated with some important diseases such as chronic kidney disease (CKD). Hyperphosphatemia has been associated with both, ageing and CKD. Old mice show an …

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MO581: Hyperphosphatemia Induces Lung Fibrosis in OLD Mice

Ana Asenjo‐Bueno, Elena Alcalde‐Estévez, Patricia Martínez‐Miguel, Gemma Olmos et autres

Abstract BACKGROUND AND AIM Hyperphosphatemia is a common condition associated with chronic kidney disease (CKD) and also with aging. Furthermore, lung dysfunction is described in both cases; however, the relationship between high phosphate levels and lung function is still unknown. The aim …

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Hyperphosphatemia-Induced Oxidant/Antioxidant Imbalance Impairs Vascular Relaxation and Induces Inflammation and Fibrosis in Old Mice

Ana Asenjo‐Bueno, Elena Alcalde‐Estévez, Mariam El Assar, Gemma Olmos et autres

Aging impairs vascular function, but the mechanisms involved are unknown. The aim of this study was to analyze whether aging-related hyperphosphatemia is implied in this effect by elucidating the role of oxidative stress. C57BL6 mice that were aged 5 months (young) and …

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Aging‐related hyperphosphatemia impairs myogenic differentiation and enhances fibrosis in skeletal muscle

Patricia Sosa, Elena Alcalde‐Estévez, Ana Asenjo‐Bueno, Patricia Plaza et autres

BACKGROUND: Hyperphosphatemia has been related to the development of sarcopenia in aging mice. We describe the intracellular mechanisms involved in the impairment of the myogenic differentiation promoted by hyperphosphatemia and analyse these mechanisms in the muscle from older mice. METHODS: cells were …

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MO596HYPERPHOSPHATEMIA INDUCES ENDOTHELIN-1 SYNTHESIS AND INFLAMMATION IN LUNG FIBROBLASTS

Ana Asenjo‐Bueno, Elena Alcalde‐Estévez, Gemma Olmos, Diego Rodrı́guez-Puyol et autres

Abstract Background and Aims Hyperphosphatemia is an aging-related condition associated to chronic diseases such as chronic kidney disease (CKD). In both cases, aging and CKD, it has been described a decline lung function, however, relationship between high serum levels of phosphate and …

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MO588DECREASED IL-15 PRODUCTION INDUCED BY HYPERPHOSPHATEMIA AS A POSSIBLE MECHANISM OF AGED-RELATED SARCOPENIA*

Elena Alcalde‐Estévez, Ana Asenjo‐Bueno, Gemma Olmos, Diego Rodrı́guez-Puyol et autres

Abstract Background and Aims The loss of muscle mass and function, termed sarcopenia, is an aging-related condition associated to some important diseases such as chronic kidney disease (CKD). Hyperphosphatemia has been related to both pathologies. A chronic subclinical inflammation and a dysregulated …

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Uraemic toxins impair skeletal muscle regeneration by inhibiting myoblast proliferation, reducing myogenic differentiation, and promoting muscular fibrosis

Elena Alcalde‐Estévez, Patricia Sosa, Ana Asenjo‐Bueno, Patricia Plaza et autres

Abstract Uraemic toxins increase in serum parallel to a decline in the glomerular filtration rate and the development of sarcopenia in patients with chronic kidney disease (CKD). This study analyses the role of uraemic toxins in sarcopenia at different stages of CKD, …

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