Kimberly Albert

Safety, tolerability, pharmacokinetic and pharmacodynamic effects of the muscarinic M1 positive allosteric modulator VU0467319 for Alzheimer’s disease: a single ascending-dose study in healthy participants

Alexander C. Conley, Alexandra P. Key, Jennifer Urbano Blackford, Jason K Russell et autres

Abstract The development of cholinergic neurotransmitter based cognitive enhancers for Alzheimer’s disease and other neuropsychiatric disorders have focused recently on allosteric modulation of specific muscarinic acetylcholine receptor (mAChR) subtypes to reduce dose-limiting side-effects that have been the hallmark of earlier orthosteric mAChR …

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Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Effects of the Muscarinic M 1 Positive Allosteric Modulator VU0467319 for Alzheimer’s disease: A Single Ascending-Dose Study in Healthy Participants

Alexander C. Conley, Alexandra P. Key, Jennifer Urbano Blackford, Jason K Russell et autres

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A pilot study of transdermal nicotine effects on facial emotion responding in non-smoking healthy controls and individuals with schizophrenia: Feasibility and effect size estimates

Alexander C. Conley, Kimberly Albert, Kristan Armstrong, Jodie V. Johnson et autres

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Estradiol treatment in young postmenopausal women with self‐reported cognitive complaints: Effects on cholinergic‐mediated cognitive performance

Alexander C. Conley, Kimberly Albert, Brenna C. McDonald, Andrew J. Saykin et autres

OBJECTIVE: Older women are at increased risk of developing Alzheimer's disease compared to men. One proposed reason is that following menopause there is a decline in estrogens. Estrogens are important for cholinergic functioning and attenuate the impact of cholinergic antagonists on cognitive …

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Differential effects of estradiol on neural and emotional stress response in postmenopausal women with remitted Major Depressive Disorder

Kimberly Albert, Brian D. Boyd, Warren D. Taylor, Paul Newhouse

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Subjective cognition and mood in persistent chemotherapy-related cognitive impairment

Jennifer N. Vega, Kimberly Albert, Ingrid A. Mayer, Warren D. Taylor et autres

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Venus and Mars: The Importance of Sex In Late-Life Neuropsychiatric Disorders

Paul Newhouse, Kimberly Albert, Julie A. Dumas, Sepideh Shokouhi

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Differential effects of estradiol on neural and emotional stress response in postmenopausal women with remitted Major Depressive Disorder

Kimberly Albert, Brian D. Boyd, Warren D. Taylor, Paul Newhouse

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Brain network functional connectivity changes following psychosocial stress in subjective cognitive decline

Kimberly Albert, Brian D. Boyd, Paul Newhouse, Warren D. Taylor

Abstract Background Neurodegenerative processes in early AD may disrupt the coordinated activity of brain networks important for the regulation of endocrine and emotional stress response. Stress reactivity and the effect of psychosocial stress on brain network function may thus be useful markers …

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Cognitive symptoms in early postmenopausal women: Impact on estrogen‐sensitive cholinergic function

Paul Newhouse, Alexander C. Conley, Kimberly Albert, Brenna C. McDonald et autres

Abstract Background Menopause is associated with increasing cognitive complaints and older women are at increased risk of developing Alzheimer’s disease (AD) compared to men. One proposed reason for this reduced cognitive performance is the loss of estrogen following the menopause transition. Estradiol …

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Cognitive symptoms in early postmenopausal women: Relationship to brain structure

Paul Newhouse, Alexander C. Conley, Kimberly Albert, Brenna C. McDonald et autres

Abstract Background Menopause is associated with increasing cognitive complaints and older women are at increased risk of developing Alzheimer’s disease (AD) compared to men. One proposed reason for this reduced cognitive performance is the loss of estrogen following the menopause transition. However, …

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Cognitive complaints are associated with smaller right medial temporal gray-matter volume in younger postmenopausal women

Alexander C. Conley, Kimberly Albert, Brian D. Boyd, Shin Gyeom Kim et autres

OBJECTIVE: Menopause is associated with increasing cognitive complaints and older women are at increased risk of developing Alzheimer disease compared to men. However, there is difficulty in early markers of risk using objective performance measures. We investigated the impact of subjective cognitive …

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