Barbara J. Martin

Risk Prediction Model for Postoperative Acute Kidney Injury in a Broad Surgical Population

Matthew S. Shotwell, Cassandra Hennessy, Barbara J. Martin, Stephen W. Behrman et autres

BACKGROUND: Postoperative acute kidney injury (AKI) significantly impacts patient recovery, increasing morbidity, mortality, and healthcare costs. This study aims to develop and validate a supervised learning model to predict the risk of AKI in patients undergoing surgical procedures, using data from the …

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Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort

Edric Winford, Jenny Lutshumba, Barbara J. Martin, Donna M. Wilcock et autres

Abstract Background and purpose The immune response changes during aging and the progression of Alzheimer’s disease (AD) and related dementia (ADRD). Terminally differentiated effector memory T cells (called T EMRA ) are important during aging and AD due to their cytotoxic phenotype …

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Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort

Edric Winford, Jenny Lutshumba, Barbara J. Martin, Donna M. Wilcock et autres

Abstract Background and Purpose The immune response changes during aging and the progression of Alzheimer’s disease (AD) and related dementia (ADRD). Terminally differentiated effector memory T cells (called T EMRA ) are important during aging and AD due to their cytotoxic phenotype …

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Alzheimer's disease and inflammatory biomarkers positively correlate in plasma in the UK‐ADRC cohort

Kate E. Foley, Zachary Winder, Tiffany L. Sudduth, Barbara J. Martin et autres

INTRODUCTION: Protein-based plasma assays provide hope for improving accessibility and specificity of molecular diagnostics to diagnose dementia. METHODS: Plasma was obtained from participants (N = 837) in our community-based University of Kentucky Alzheimer's Disease Research Center cohort. We evaluated six Alzheimer's disease …

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Factors and Barriers to Goals-of-Care Conversations for Patients With Cancer and Inpatient Mortality

Margaret Wheless, Julie Jiyun Lee, Henry J. Domenico, Barbara J. Martin et autres

PURPOSE Conversations about personal values and goals of care (GOC) at the end of life are essential in caring for patients with advanced cancer. However, GOC conversations may be influenced by patient and oncologist factors during transitions of care. METHODS We electronically …

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Goals-of-care and serious illness conversations for patients with cancer with inpatient mortality.

Julie Jiyun Lee, Margaret Wheless, Henry J. Domenico, Barbara J. Martin et autres

184 Background: Goals-of-care (GOC) and serious illness conversations are an integral part of personalized cancer care, particularly toward the end of life (EOL). Eliciting patients (pts)’ preferences and values facilitates informed decision-making throughout the disease course and enables oncologists to provide patient-centered …

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Nursing Workforce Challenges in the Postpandemic World

Ellen T. Kurtzman, Lauren V. Ghazal, Shirley Girouard, Chenjuan Ma et autres

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Factors Influencing Compliance in Independent In-Home Exercise Trial for Older Adults (P2-6.002)

Margaret R. Kelly, Katherine Snyder, Justin M. Barber, Barbara J. Martin et autres

An exploration of factors influencing participant compliance in an independent, in-home exercise program for older adults.

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Examining the association between blood‐based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort

Zachary Winder, Tiffany L. Sudduth, Sonya Anderson, Ela Patel et autres

INTRODUCTION: Clinically, detection of disease-causing pathology associated with Alzheimer's disease (AD) and vascular contributions to cognitive impairment and dementia (VCID) is limited to magnetic resonance imaging and positron emission tomography scans, which are expensive and not widely accessible. Here, we assess angiogenic, …

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Palliative Care Exposure Relative to Predicted Risk of Six-Month Mortality in Hospitalized Adults

Rajiv Agarwal, Henry J. Domenico, Sreenivasa R Balla, Daniel W. Byrne et autres

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The Impact of Functional Dependence and Related Surgical Complications on Postoperative Mortality

Jacob C. Clifton, Milo Engoren, Matthew S. Shotwell, Barbara J. Martin et autres

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Pain Management and Opioid Therapy: Persistent Knowledge Gaps Among Primary Care Providers

Chad Williamson, Barbara J. Martin, Charles E. Argoff, Christopher Gharibo et autres

INTRODUCTION: Given the opioid epidemic in the US, it is vital that clinicians who prescribe opioids for pain management to do so in an evidence-based manner, eg considering all pharmacologic and non-pharmacologic options, assessing risk of opioid use disorder prior to initiating …

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