Silvana Di Palma

Extrathoracic thymoma at the level III neck level

Hugo Smith, Hitesh Mathew, David Walker, Silvana Di Palma

A male patient in his 60s was investigated for a suspicious mass in the level 3 neck space. His initial core biopsy was reported elsewhere as metastatic squamous cell carcinoma. Histological review as part of the multidisciplinary team (MDT) discussion policy at …

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Evolving Concepts in Salivary Duct Carcinoma: A Narrative Review

Marvin C. Masalunga, Patrick J. Bradley, Carla van Herpen, Toshitaka Nagao et autres

Salivary duct carcinoma (SDC) is an aggressive neoplasm that typically involves the major salivary glands. This rapidly growing tumor is known to recur and metastasize to the neck nodes and to distant sites. Given its poor prognosis, researchers have focused on identifying …

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Aggressive acinic cell carcinoma with and without high-grade transformation: a report of two cases

Dharani Kanagarajah, Sakura Abeygunawardhane, Silvana Di Palma

Diagnostic interobserver variability of atypia assessment in columnar cell lesions among a group of expert breast pathologists in the United Kingdom and the Republic of Ireland, on behalf of the UK national coordinating committee for breast pathology

Soha El Sheikh, Mohamed A Mansour, Elena Provenzano, Abeer M. Shaaban et autres

AIMS: Atypical ductal hyperplasia and flat epithelial atypia (FEA) have defined diagnostic criteria, yet there is variation in the interpretation of these criteria, particularly when the atypia is present in a background of columnar cell lesions (CCLs). This study focuses upon cases …

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Is it time for molecular assessment of breast biomarkers?

Farrokh Pakzad, Jon Horsnell, Tracey Irvine, Polly Partlett et autres

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Breast Cancer Molecular Subtyping in Practice: A Real-World Study of the APIS Breast Cancer Subtyping Assay in a Consecutive Series of Breast Core Biopsies

Silvana Di Palma, Panagiotis Koliou, Alex Simonovic, Daniela Costa et autres

The APIS Breast Cancer Subtyping Kit is an mRNA-based assessment of the seven parameters including three biomarkers routinely assessed in all the newly diagnosed breast cancers (BC), oestrogen receptor (ER), progesterone receptor (PR) and HER-2 and an additional four genes that create …

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Breast Cancer Molecular Subtyping in Practice: A Real-World Study of the APIS Breast Cancer Subtyping Assay in a Consecutive Series of Breast Core Biopsies

Silvana Di Palma, Panagiotis Koliou, Alex Simonovic, Daniela Costa et autres

The APIS Breast Cancer Subtyping Kit is an mRNA-based assessment of the three biomarkers routinely assessed in all newly diagnosed breast cancers (BC), estrogen receptor (ER), progesterone receptor (PR), and HER2 as well as an additional four genes that create a novel …

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Nutritional status of patients with advanced gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENS) in Spain: Nutrigetne study

Lorena Hernandez-Rienda, A. Casterás, M. Giribés, María Soledad Librizzi et autres

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Concordance of HER2-low scoring in breast carcinoma among expert pathologists in the United Kingdom and the republic of Ireland –on behalf of the UK national coordinating committee for breast pathology

Mohamed Zaakouk, Cecily Quinn, Elena Provenzano, Clinton Boyd et autres

BACKGROUND: Recent clinical evidence showed that breast cancer with low HER2 expression levels responded to trastuzumab deruxtecan therapy. The HER2-low cancers comprise immunohistochemistry (IHC) score 1+ and 2+ ISH non-amplified tumours, currently classified as HER2 negative. Little data exists on the reproducibility …

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Salivary Gland Secretory Carcinoma

Martina Baněčková, Lester D.�R. Thompson, Martin Hyrcza, Tomáš Vaněček et autres

Salivary gland secretory carcinoma (SC), previously mammary analog SC, is a low-grade malignancy characterized by well-defined morphology and an immunohistochemical and genetic profile identical to SC of the breast. Translocation t(12;15)(p13;q25) resulting in the ETV6 :: NTRK3 gene fusion is a characteristic …

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Management of breast incidentalomas: A closed loop audit experience at royal surrey foundation trust

Abigail Burrows, Shramana Banerjee, Kirakoula Georgas, Meera Joshi et autres

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Impact of COVID-19 on the practice of breast pathologists: a survey of breast pathologists in the UK and Ireland

Mirna Elghobashy, Lutful Wahab, Anu Gunavardhan, Emma O’Sullivan et autres

AIMS: There is little information on the impact of COVID-19 on breast pathologists. This survey assessed the effect of the COVID-19 pandemic on UK and Ireland-based breast pathologists to optimise working environments and ensure preparedness for potential future pandemics. METHODS: A 35-question …

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