Ji Shin Lee

Clinical significance of TAM receptor in the minor salivary glands of patients with Sjögren’s disease

Sung-Eun Choi, Ji‐Hyoun Kang, Dong-Jin Park, Nah Ihm Kim et autres

Sjögren's disease is a chronic autoimmune disorder characterized by lymphocytic infiltration of the salivary and lacrimal glands, often accompanied by systemic manifestations. Dysregulation of immune homeostasis, including impaired clearance of apoptotic cells and aberrant type I interferon (IFN) signaling, plays a key …

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Evaluating accuracy and concordance of pathologists and the utility of AI assistance software for digital HER2 IHC assessment in breast cancer including HER2-ultralow scoring: An international multicenter observational study.

Gabriela Acosta Haab, Chee Leong Cheng, Le-Van Quang, Mai Soliman et autres

1078 Background: The emergence of novel therapeutic agents demonstrating improved progression-free survival (PFS) and overall survival (OS) in breast cancer patients with low HER2 expression underscores the need for accurate and reproducible HER2 status assessment. However, challenges such as subjective interpretation of …

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Cystic Breast Lesions: Diagnostic Approach and US Assessment

Hyo Soon Lim, Hyo‐jae Lee, Ji Shin Lee, Min Ho Park et autres

Radiologists must be familiar with the precise definitions and appropriate assessment and management recommendations for various cystic breast lesions to reduce unnecessary follow-up and biopsies while preventing cancers from being missed or dismissed.

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Claudin 18.2 expression profile in primary tumors and their ovarian metastases: implications for targeted therapy

Nah Ihm Kim, John Y. M. Koo, Sung Sun Kim, Ji Young Lee et autres

BACKGROUND: Claudin 18.2 (CLDN18.2), a tight junction protein predominantly expressed in the normal gastric epithelium, has recently emerged as a potential therapeutic target in various solid tumors. Despite growing interest, comprehensive data on CLDN18.2 expression across primary tumors from different organs and …

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Radiological and Pathological Challenges in Diagnosing Pleomorphic Lobular Carcinoma In Situ With Focal Invasion: A Case Report

Hyo‐jae Lee, Chan Park, Won Gi Jeong, Ji Shin Lee et autres

Pleomorphic lobular carcinoma ;in situ (PLCIS) is a relatively uncommon subtype of lobular neoplasia, characterized by large pleomorphic discohesive cells exhibiting marked nuclear atypia, frequent central comedo-necrosis, and microcalcifications. Owing to these features, PLCIS is difficult to distinguish using radiological and histological …

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Multiple Hepatic Metastases Following Breast Surgery for Ductal Carcinoma in Situ without Invasive Recurrence: A Case Report

Min Ho Park, Ji Shin Lee, Yong Min Na

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Prediction of early clinical response to neoadjuvant chemotherapy in Triple-negative breast cancer: Incorporating Radiomics through breast MRI

Hyo‐jae Lee, Jeong Hoon Lee, Jong Eun Lee, Yong Min Na et autres

This study assessed pretreatment breast MRI coupled with machine learning for predicting early clinical responses to neoadjuvant chemotherapy (NAC) in triple-negative breast cancer (TNBC), focusing on identifying non-responders. A retrospective analysis of 135 TNBC patients (107 responders, 28 non-responders) treated with NAC …

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Abstract PO1-24-11: Distinct patterns of MHC class I, PD-L1 expression, and T-cell infiltration in different subtypes of ductal carcinoma in situ of the breast

Nah Ihm Kim, Min Ho Park, Ji Shin Lee

Abstract Background: Ductal carcinoma in situ (DCIS) of the breast encompasses various subtypes with distinct behaviors. Immune cell infiltration within the tumor microenvironment is thought to influence DCIS progression. Tumor-infiltrating lymphocytes (TILs) serve as a surrogate marker for the adaptive immune response. …

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The Subcutaneous Variant Dermatofibrosarcoma Protuberans of the Breast With Nipple Areolar Complex Invasion Treated With Central Lumpectomy: A Case Report

Yong Min Na, Yong Bin Kwon, Sang Yun An, Hye Un et autres

Dermatofibrosarcoma protuberans (DFSP) is a rare low-grade soft tissue sarcoma and the breast is less commonly affected than the torso. DFSP can be misdiagnosed as neurofibroma, desmoid tumor, malignant melanoma, or Kaposi sarcoma. A variant of DFSP originates from the subcutaneous layer …

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Uterine rupture due to adenomyosis in an adolescent: A case report and review of literature

Nah Ihm Kim, Ji Shin Lee, Jong Hee Nam

BACKGROUND: Uterine rupture is a fatal medical complication with a high mortality rate. Most cases of uterine rupture occur in late pregnancy or during labor and are mainly related to uterine scarring due to previous surgical procedures. Adenomyosis is a possible risk …

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Data from SPIN90 Depletion and Microtubule Acetylation Mediate Stromal Fibroblast Activation in Breast Cancer Progression

Eunae You, Yun Hyun Huh, Ahreum Kwon, So Hee Kim et autres

Abstract Biomechanical remodeling of stroma by cancer-associated fibroblasts (CAF) in early stages of cancer is critical for cancer progression, and mechanical cues such as extracellular matrix stiffness control cell differentiation and malignant progression. However, the mechanism by which CAF activation occurs in …

Supplementary Figures and Legends from SPIN90 Depletion and Microtubule Acetylation Mediate Stromal Fibroblast Activation in Breast Cancer Progression

Eunae You, Yun Hyun Huh, Ahreum Kwon, So Hee Kim et autres

Figure S1 (Related to Fig. 1). Low expression of SPIN90 in cancer stroma and CAFs. Figure S2 (Related to Fig. 2). CAFs derived from Spin90-/- mice show increased activation. Figure S3 (Related to Fig. 3). Loss of SPIN90 induces CAF differentiation. Figure …