Jia Ouyang

SKP2 protein as a prognostic biomarker for glioma and promotes tumor progression by regulating the cell cycle

Lei Guan, Haima Li, Yezu Liu, Jia Ouyang et autres

SKP2 (S-phase kinase-associated protein 2) plays an important role in the regulation of the cell cycle, tumorigenesis, progression, and metastasis. However, its functional role in gliomas is currently unclear. This study aimed to investigate the relationship between SKP2 and the progression of …

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Association between monocyte-to-high-density lipoprotein cholesterol ratio and all-cause mortality in stroke patients: Exploring the potential mediating role of serum creatinine in a NHANES-based study

Bo Hei, Jia Ouyang, Jixia Fang, Bin Wang et autres

Identifying reliable prognostic biomarkers is crucial for the effective management of stroke patients. The monocyte-to-high-density lipoprotein cholesterol ratio (MHR), calculated as the ratio of blood monocyte count to high-density lipoprotein levels, is commonly used to assess the relationship between inflammation and cardiovascular …

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Platycodin D Enhances Glioma Sensitivity to Temozolomide by Inhibition of the Wnt/β-Catenin Pathway

Haima Li, Jia Ouyang, Xuelian Wang, Chao Qian

Background: Temozolomide (TMZ) is a first-line chemotherapeutic agent for gliomas. However, its efficacy is limited by drug resistance. Platycodin D (PD) exhibits notable anti-glioma activity The objective of this study was to investigate the potential of PD to augment glioma sensitivity to …

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Predictive Factors for Herpes Simplex Virus Reactivation in Patients with Trigeminal Neuralgia After Surgery

Zihao Zhang, Qingpei Hao, Gang Wu, Jia Ouyang et autres

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Platycodin D inhibits glioblastoma cell proliferation, migration, and invasion by regulating DEPDC1B-mediated epithelial-to-mesenchymal transition

Jia Ouyang, Haima Li, Guangyong Wu, Bo Hei et autres

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Comparison of GPi-DBS, STN-DBS, and pallidotomy in primary Meige syndrome

Qingpei Hao, Gaoquan Lv, Wentao Zheng, Zihao Zhang et autres

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Platycodin D suppresses proliferation, migration, and invasion of human glioblastoma cells through regulation of Skp2

Haima Li, Jia Ouyang, Ruen Liu

BACKGROUND: Platycodin D (PD) is a major bioactive component of Platycodon grandiflorum, a medicinal herb that is widely used in China, and is effective against various human cancers, including glioblastoma multiforme (GBM). S phase kinase-related protein 2 (Skp2) is oncogenic and overexpressed …

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Doxorubicin Delivered via ApoE-Directed Reduction-Sensitive Polymersomes Potently Inhibit Orthotopic Human Glioblastoma Xenografts in Nude Mice

Jia Ouyang, Yu Jiang, Chao Deng, Zhiyuan Zhong et autres

PURPOSE: Glioblastoma multiforme (GBM) poorly responds to chemotherapy owing to the existence of blood-brain barriers (BBB). It has been a long desire to develop BBB-permeable vehicles to facilitate drug targeting to GBM. METHOD AND RESULTS: Here, we report that doxorubicin hydrochloride loaded …

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Pallidal deep brain stimulation in primary Meige syndrome: clinical outcomes and psychiatric features

Qingpei Hao, Dongliang Wang, Jia Ouyang, Hu Ding et autres

OBJECTIVES: To study the efficacy and safety of bilateral globus pallidus internus deep brain stimulation (GPi-DBS) in refractory Meige syndrome (MS) and evaluate the psychiatric disorders before and after surgery. METHODS: Twenty-two patients with MS treated with bilateral GPi-DBS were retrospectively analysed …

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Subthalamic Nucleus Deep Brain Stimulation in Primary Meige Syndrome: A 1-Year Follow-Up Study

Jia Ouyang, Qingpei Hao, Runze Zhu, Guangyong Wu et autres

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Selective Cell Penetrating Peptide‐Functionalized Envelope‐Type Chimeric Lipopepsomes Boost Systemic RNAi Therapy for Lung Tumors

Min Qiu, Jia Ouyang, Yaohua Wei, Jian Zhang et autres

Small interfering RNA (siRNA) is considered a highly specific and potent biotherapeutic that holds tremendous potential for the treatment of various diseases. The clinical translation of siRNA is, however, greatly impeded by the lack of safe and efficient delivery vehicles in vivo. …

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Verbascoside suppresses the migration and invasion of human glioblastoma cells via targeting c-Met-mediated epithelial-mesenchymal transition

Bo Hei, Jia Wang, Guangyong Wu, Jia Ouyang et autres

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