Swati Dey

Combined Analysis of Cardiac Repolarization Entropy and Magnetic Resonance Imaging Enhances Risk Stratification of Patients Receiving a Primary-Prevention ICD

Tanmay Gokhale, Swati Dey, Worawan B. Limpitikul, Nitesh Gautam et autres

BACKGROUND: , a nonlinear electrocardiographic (ECG) measure of cardiac repolarization dynamics, predict ventricular tachyarrhythmias (VTs) and sudden cardiac arrest. OBJECTIVES: are fundamentally distinct structural and electrical measures, we hypothesized that they add major independent prognostic value to conventional clinical predictors of sudden …

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Evaluating Free AI Chatbots on Civic and Human-Rights Topics: A 15-Country Expert Study

Marius Dragomir, Charles Autheman, Jorge Bossio, Luis Miguel Carriedo et autres

Large language models (LLMs) increasingly shape how journalists, researchers, and the general public access information on high-stakes topics such as elections, human rights, identity politics, historical memory, and public services. People around the world now turn to free AI assistants to understand …

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Evaluating Free AI Chatbots on Civic and Human-Rights Topics: A 15-Country Expert Study

Marius Dragomir, Charles Autheman, Jorge Bossio, Luis Miguel Carriedo et autres

Large language models (LLMs) increasingly shape how journalists, researchers, and the general public access information on high-stakes topics such as elections, human rights, identity politics, historical memory, and public services. People around the world now turn to free AI assistants to understand …

at, es, dk, ee, pe, ar, br (code pays fourni par la source)

Evaluating Free AI Chatbots on Civic and Human-Rights Topics: A 15-Country Expert Study

Marius Dragomir, Charles Autheman, Jorge Bossio, Luis Miguel Carriedo et autres

Large language models (LLMs) increasingly shape how journalists, researchers, and the general public access information on high-stakes topics such as elections, human rights, identity politics, historical memory, and public services. People around the world now turn to free AI assistants to understand …

at, es, dk, ee, pe, ar, br (code pays fourni par la source)

Abstract 4136181: Automated Personalized Modulation of the Sympathetic “fight-or-flight” Reflex In Vivo Using Implantable Microdevices for Enhancing Neurocardiac Function and Reducing Mortality Risk.

D. Kundu, Steven Richard Jones, Swati Dey, Deeptankar DeMazumder

Background: The sympathetic nervous system (SNS) is a critical regulator of cardiovascular function. Whereas acute SNS activation elicits positive inotropy and confers survival advantage, persistent SNS hyperactivity is maladaptive and can lead to arrhythmias, cardiac arrest and heart failure. Hypothesis: Automated optogenetic …

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Abstract 4136938: Autonomous Personalized Dynamic ECG Analysis Predicts 1-hour Incidence of Sudden Cardiac Arrest

Steven Richard Jones, Swati Dey, Deeptankar DeMazumder

Background: Sudden cardiac arrest (SCA) is a leading cause of death in the USA. Defibrillators prevent SCA by delivering shocks for sustained ventricular tachyarrhythmias (VT). However, current clinical methods for predicting SCA are limited. We have shown that distinct nonlinear fluctuation patterns …

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Design optimization of effective modulus through variation in pore geometries of Stainless Steel 316L

Krishnendu Bhowmik, Swati Dey, Sagnik Datta, Apurba Das et autres

Abstract Three-dimensional finite element analyses are carried out using cubic shaped representative volume element with spherical and ellipsoidal pores. The aim of this present study is to design a metal block with targeted effective modulus of elasticity in different directions with various …

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Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function, and prevents sudden arrhythmic death in failing hearts

Pooja Joshi, Shanea Estes, Deeptankar DeMazumder, Björn C. Knollmann et autres

Sudden cardiac death (SCD) from ventricular tachycardia/fibrillation (VT/VF) is a leading cause of death, but current therapies are limited. Despite extensive research on drugs targeting sarcolemmal ion channels, none have proven sufficiently effective for preventing SCD. Sarcoplasmic ryanodine receptor 2 (RyR2) Ca …

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Author Response: Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function, and prevents sudden arrhythmic death in failing hearts

Pooja Joshi, Shanea Estes, Deeptankar DeMazumder, Björn C. Knollmann et autres

Each year, more than 300,000 people experience cardiac arrest or sudden cardiac death. Sudden cardiac death is caused by irregular heartbeats known as ventricular tachycardia or ventricular fibrillation, which prevent the heart from pumping blood. During a regular heart rhythm, the heart …

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Reviewer #2 (Public Review): Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function and prevents sudden arrhythmic death in failing hearts

Pooja Joshi, Shanea Estes, Deeptankar DeMazumder, Björn C. Knollmann et autres

Sudden cardiac death (SCD) from ventricular tachycardia/fibrillation (VT/VF) are a leading cause of death, but current therapies are limited. Despite extensive research on drugs targeting sarcolemmal ion channels, none have proven sufficiently effective for preventing SCD. Sarcoplasmic ryanodine receptor 2 (RyR2) Ca2+ …

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Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function and prevents sudden arrhythmic death in failing hearts

Pooja Joshi, Shanea Estes, Deeptankar DeMazumder, Björn C. Knollmann et autres

Abstract Introduction Sudden cardiac death (SCD) from ventricular tachycardia/fibrillation (VT/VF) are a leading cause of death, but current therapies are limited. Despite extensive research on drugs targeting sarcolemmal ion channels, none have proven sufficiently effective for preventing SCD. Sarcoplasmic ryanodine receptor 2 …

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Reviewer #1 (Public Review): Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function and prevents sudden arrhythmic death in failing hearts

Pooja Joshi, Shanea Estes, Deeptankar DeMazumder, Björn C. Knollmann et autres

Sudden cardiac death (SCD) from ventricular tachycardia/fibrillation (VT/VF) are a leading cause of death, but current therapies are limited. Despite extensive research on drugs targeting sarcolemmal ion channels, none have proven sufficiently effective for preventing SCD. Sarcoplasmic ryanodine receptor 2 (RyR2) Ca2+ …