Ge Gao

Study on the Spatio-Temporal Differentiation and Driving Mechanism of Ecological Security in Dongping Lake Basin, Shandong Province, China

Yibing Wang, Ge Gao, Mingming Li, Kuanzhen Mao et autres

Ecological security evaluation serves as the cornerstone for ecological management decision-making and spatial optimization. This study focuses on the Dongping Lake Basin. Based on the Pressure–State–Response (PSR) model framework, it integrates ecological risk, ecosystem health, and ecosystem service indicators. Utilizing methods including …

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Renal Ischemia Reperfusion Injury Severity Differentiation Using Hyperpolarized Imaging

Alexander I. Zavriyev, James H Nguyen, Bukola Y. Adebesin, Molly Sheehan et autres

Purpose: In this work, we investigated the ability of hyperpolarized (HP) carbon-13 (13C) MRI to noninvasively differentiate renal ischemia/reperfusion injury (IRI) severity using co-polarized pyruvate and urea in a female translational mouse model.

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Hydrochemical Characteristics and Controlling Factors of Hengshui Lake Wetland During the Dry Season, North China

Hongyan An, Tianjiao Wang, Xianzhou Meng, Dongyang Song et autres

Wetland lakes are crucial ecosystems that serve as vital ecosystems that harbor rich biodiversity and provide essential ecological services, particularly in regulating regional water resources, purifying water quality, and maintaining ecological equilibrium. This study aims to conduct an in-depth investigation into the …

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Overexpression of LINC00880 promotes colorectal cancer growth

Ge Gao, Peiwen Xu, Chunyu Yang, Mengyuan Qian et autres

Background: in CRC progression. Methods: on cell cycle pathway. Results: . Conclusions: is upregulated in CRC and promotes tumor growth.

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Hydrochemical Characteristics and Genesis of Groundwater in Taoshan Granite Body, Yushan Uplift Area, South Jiangxi, China

Xinfeng Wang, Yan Wang, Ge Gao, Mingming Li et autres

Drawing upon an understanding of the distribution characteristics of groundwater in the Taoshan rock mass within the Yushan Uplift region of southern Jiangxi, this study utilizes mathematical statistics, ion ratio coefficients, factor analysis, and mineral dissolution equilibrium methods to characterize in detail …

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Humanized monoacylglycerol acyltransferase 2 mice develop metabolic dysfunction-associated steatohepatitis

J. Jose Corbalan, Pranavi Jagadeesan, Karla K. Frietze, Rulaiha E. Taylor et autres

) are resistant to diet-induced fatty liver, suggesting hMOGAT2 inhibition is a viable option for treating metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH). We generated humanized hMOGAT2 mice (HuMgat2) for use in pre-clinical studies testing the efficacy of hMOGAT2 inhibitors …

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LINC01852 inhibits the tumorigenesis and chemoresistance in colorectal cancer by suppressing SRSF5-mediated alternative splicing of PKM

Zehua Bian, Fan Yang, Peiwen Xu, Ge Gao et autres

BACKGROUND: Colorectal cancer (CRC) is a major cause of cancer-related deaths worldwide, and chemoresistance is a major obstacle in its treatment. Despite advances in therapy, the molecular mechanism underlying chemoresistance in CRC is not fully understood. Recent studies have implicated the key …

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Low-dose Rivaroxaban: is it a safe alternative in Chinese older patients?

Wei Yang, Wenyuan Li, Ge Gao, Dan Luo et autres

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Atorvastatin Ameliorates Doxorubicin-Induced Cardiomyopathy by Regulating the Autophagy–Lysosome Pathway and Its Upstream Regulatory Factor Transcription Factor EB

Shi-liang Jiang, Wan-Ching Chou, Linqing Tao, Zhaoyang Qiu et autres

ABSTRACT: Doxorubicin is a widely used anticancer drug in clinical practice, and its myocardial toxicity is the main concern in oncotherapy. Statins are commonly used as hypolipidemic drugs. Recent studies have also focused on the effects of statins on autophagy. Autophagy is …

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In vivo and in vitro protective effects of shengmai injection against doxorubicin-induced cardiotoxicity

Peng Zhou, Ge Gao, Chunchun Zhao, Jingya Li et autres

Context Shengmai injection (SMI) has been used to treat heart failure.Objective This study determines the molecular mechanisms of SMI against cardiotoxicity caused by doxorubicin (DOX).Materials and methods In vivo, DOX (15 mg/kg) was intraperitoneally injected in model, Dex (dexrazoxane), SMI-L (2.7 mL/kg), …

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Lysosome-targeting red fluorescent probe for broad carboxylesterases detection in breast cancer cells

Yanyan Sun, Xiaonan Zhou, Liyuan Sun, Xiuxiu Zhao et autres

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Development of an optimal protocol for isolation and purification of human granulosa cells in patients with different ovarian reserves

Ying Han, Ge Gao, Shuang Li, Nan Xiao et autres

The aim of the current study was to develop an accurate and reproducible method for isolation of granulosa cells (GCs) in patients with different ovarian reserves. The cells of healthy individuals and patients with polycystic ovary syndrome (PCOS) were isolated using a …

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