Michael A. Sandholzer

Determining Volumetric Shrinkage Trends of Burnt Bone Using Micro‐CT

Sarah Ellingham, Michael A. Sandholzer

Understanding the degree and pattern of shrinkage undergone by bone when subjected to heating is crucial to accurately deduce a biological profile from incinerated remains. X-ray microtomography (micro-CT) enables a nondestructive insight into hard tissue structural changes, while allowing for an accurate …

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Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers

Jonathan M. Tsai, Rahul Sinha, Jun Seita, Nathaniel B. Fernhoff et autres

mesothelium responded to hypoxia by early up-regulation of hypoxia-inducible factor 1 alpha (HIF1α) that preceded adhesion development. Inhibition of HIF1α with small molecules ameliorated the injury program in damaged mesothelium and was sufficient to diminish adhesion severity in a mouse model. Analyses …

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High-resolution μCT of a mouse embryo using a compact laser-driven X-ray betatron source

J. M. Cole, Daniel Symes, N. Lopes, Jonathan Wood et autres

photons per pulse), small (diameter <1 μm), and has a critical energy >15 keV. Stable X-ray performance enabled tomographic imaging of equivalent quality to that of the μCT scanner, an important confirmation of the suitability of the laser-driven source for applications. The …

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Images And Supporting Data For High-Resolution Μct Of A Mouse Embryo Using A Compact Laser-Driven X-Ray Betatron Source

J. M. Cole, Daniel Symes, N. Lopes, Jonathan Wood et autres

A high resolution x-ray CT scan of an embryonic mouse sample was performed with the betatron x-ray source produced by a laser wakefield accelerator. This data deposition includes all of the raw images of the mouse sample, information regarding their indexing, featured …

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Images And Supporting Data For High-Resolution Μct Of A Mouse Embryo Using A Compact Laser-Driven X-Ray Betatron Source

J. M. Cole, Daniel Symes, N. Lopes, Jonathan Wood et autres

A high resolution x-ray CT scan of an embryonic mouse sample was performed with the betatron x-ray source produced by a laser wakefield accelerator. This data deposition includes all of the raw images of the mouse sample, information regarding their indexing, featured …

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The Use of Micro-Computed Tomography to Determine Volumetric Shrinkage Patterns of Thermally Damaged Bone

Sarah Ellingham, Michael A. Sandholzer, Tim Thompson, Meezanul Islam et autres

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice

Kan Xie, Frauke Neff, Astrid Markert, Jan Rozman et autres

Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than …

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The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.

Helmut Fuchs, Sibylle Sabrautzki, Gerhard K. H. Przemeck, Stefanie Leuchtenberger et autres

mutant mouse line may serve as a new model for further studying the effect of impaired SCUBE3 gene function.

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Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation

Sibylle Sabrautzki, Michael A. Sandholzer, Bettina Lorenz‐Depiereux, Robert Brommage et autres

Animal models resembling human mutations are valuable tools to research the features of complex human craniofacial syndromes. This is the first report on a viable dominant mouse model carrying a non-synonymous sequence variation within the endothelin receptor type A gene (Ednra c.386A>T, …

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High-resolution tomographic imaging using coherent hard x-rays from compact laser driven accelerators

Symes, Z. Najmudin, J. M. Cole, Jonathan Wood et autres

Extremely bright coherent femtosecond x-ray pulses are generated in compact laser-driven electron accelerators. Micro-tomography obtained with the Gemini laser indicates the usefulness of these sources in research and clinical applications.

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Understanding nature’s residual strain engineering at the human dentine–enamel junction interface

Tan Sui, Alexander J.G. Lunt, Nikolaos Baimpas, Michael A. Sandholzer et autres

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High-resolution Tomographic Imaging Using Coherent Hard x-rays From Compact Laser Driven Accelerators

D. R. Symes, Z. Najmudin, J. M. Cole, Jonathan Wood et autres

Extremely bright coherent femtosecond x-ray pulses are generated in compact laserdriven electron accelerators. Micro-tomography obtained with the Gemini laser indicates the usefulness of these sources in research and clinical applications.

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