Cun‐Gen Ma

Hydroxysafflor Yellow A Reduced Neuroinflammation Induced by Astrocyte-Derived IL-17A by Inhibiting the IL-17RA/ACT1/NF-κB/IL-17A Loop After OGD/R

Lijuan Song, Kexin Liu, Yanzhe Duan, Jiezhong Yu et autres

Introduction: Neuroinflammation induced by astrocytes has garnered significant attention recently. The IL-17A/IL-17RA signal pathway plays an important role in ischemic stroke (IS). Hydroxysafflor yellow A (HSYA) has been reported to have anti-apoptotic and anti-inflammatory properties that can protect neurons. In this study, …

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Robotic arm-assisted additive manufacturing of continuous SiCf/SiC ceramic matrix composites with high performance via precursor infiltration and pyrolysis

Tianyang Li, Yao Zhang, Cun‐Gen Ma, Xiaolong Gong et autres

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Biomimetic crossed-lamellar architecture: Elevating mechanical performance of continuous SiCf/SiC composites via robot-assisted 3D printing

Kai Liu, Yao Zhang, Tianyang Li, Xinyang Li et autres

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A Damage Constitutive Model for Rock Considering Crack Propagation Under Uniaxial Compression

Shengnan Li, Yu Li, Xianglong Liu, Jun-Hao Tan et autres

This study aims to accurately characterize the nonlinear stress–strain evolution of rocks under uniaxial compression considering crack propagation. First, the rock meso-structure was generalized into intact rock unit cells, crack propagation damage unit cells, and pore unit cells according to phenomenological theory. …

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Mechanism of sepsis regulation by ELANE via macrophage polarization

Linghan Leng, Ying Yang, Hongye Zhang, Wensheng Peng et autres

To identify the core immune regulatory gene ELANE in sepsis and explore its mechanism in regulating sepsis through macrophage polarization. Peripheral blood RNA sequencing and bioinformatics analysis were performed on 20 sepsis patients and 10 healthy controls. Differential gene expression (DEGs) screening, …

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Retraction of Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis

Jingxian Yang, Zhilong Jiang, Denise C. Fitzgerald, Cun‐Gen Ma et autres

[Inhibitory effect of electroacupuncture on microglial activation via Notch1/Hes1 pathway in Parkinson's disease mice].

Yang Liu, Huijie Fan, Tiansheng Zhang, Liran Wang et autres

Objective: To observe the effects of electroacupuncture (EA) on improving motor function and regulating microglial activation based on Notch receptor 1 (Notch1)/Hes family bHLH transcription factor 1 (Hes1) pathway in mice with Parkinson's disease (PD). Methods: Thirty-six male C57BL/6 mice were randomly …

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Proanthocyanidin B2 Alleviates Cuprizone‐Induced Demyelination by Regulating the Astrocytic xCT/GSH/GPX4 Axis

Yan-Xia Hou, Ying Ian Chen, Meng Pu, Lulu Zheng et autres

BACKGROUND: Multiple sclerosis (MS) is marked by inflammatory demyelination in the central nervous system (CNS), involving diverse glial populations. This pathological process is associated with inflammation and oxidative stress. Proanthocyanidin B2 (PCB2), with its potent antioxidant properties, has been shown to alleviate …

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Translational medicine research on the role of key gene network modulation mediated by procyanidin B2 in the precise diagnosis and treatment of multiple sclerosis

Meng Pu, Di Guo, Ying Xiao, Jinzhu Yin et autres

OBJECTIVE: The present study aimed to investigate the potential role and molecular mechanism of procyanidin B2 (PCB2) in the treatment of multiple sclerosis (MS), with the hope of providing novel strategies for the precision treatment of MS. METHODS: The target genes of …

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[Effects of combined use of active ingredients in Buyang Huanwu Decoction on oxygen-glucose deprivation/reglucose-reoxygenation-induced inflammation and oxidative stress of BV2 cells].

Ying Chen, Qin Su, Maohua Rong, Shining Ge et autres

This study aims to explore the effects and action mechanisms of the active ingredients in Buyang Huanwu Decoction(BYHWD), namely tetramethylpyrazine(TMP) and hydroxy-safflor yellow A(HSYA), on oxygen-glucose deprivation/reglucose-reoxygenation(OGD/R)-induced inflammation and oxidative stress of microglia(MG). Network pharmacology was used to screen the effective monomer …

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Stochastic Perturbation–Galerkin Method for Structural Random Eigenvalue Problems

Bin Huang, Yunchong Chen, Zhiqiang Long, Cun‐Gen Ma et autres

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Impact of virtual reality-based rehabilitation on poststroke depression: A systematic review and meta-analysis

Ying Wei, Hao Tian, Cun‐Gen Ma, Lijuan Song

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