Yukihiro Shimizu

Effects of Rehabilitation and Hospital Art on Mood of Inpatients in a Rehabilitation Ward: A Preliminary Study

Hiroo Koshisaki, Makoto Oura, Daishi Ogawa, Sachiko Nakai et autres

INTRODUCTION: Improvements in activities of daily living are closely linked to patients' moods. While hospital art has been reported to have a positive influence on mood, its effectiveness in rehabilitation settings remains unclear. PURPOSE: This study investigates the effects of rehabilitation and …

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Objective Response and Progression-Free Survival Contribute to Prolong Overall Survival in Atezolizumab plus Bevacizumab Treatment for Unresectable Hepatocellular Carcinoma

Kazuto Tajiri, Kenichiro Tsukada, Yoshiharu Tokimitsu, Yuchi Motofuji et autres

INTRODUCTION: Atezolizumab plus bevacizumab (Atez/Bev) is a standard treatment for unresectable hepatocellular carcinoma (HCC) due to its good antitumor and survival prolongation effects. Post-progression survival (PPS) has been reported to be a great contributor in the treatment with tyrosine kinase inhibitors for …

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Long term changes in thrombocytopenia and leucopenia after HCV eradication with direct-acting antivirals

Kazuto Tajiri, Kazuhiko Okada, Hiroyuki Ito, Kengo Kawai et autres

BACKGROUND: Thrombocytopenia due to hypersplenism is a major complication of hepatitis C virus (HCV)-associated cirrhosis. HCV eradication improves these complications in some patients, but the long-term effects of HCV eradication on these complications remain unclear, especially in patients treated with direct acting …

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Identification and Prognostication of End-of-Life State Using a Japanese Guideline-Based Diagnostic Method: A Diagnostic Accuracy Study

Masahisa Arahata, Hidesaku Asakura, Eriko Morishita, Shinji Minami et autres

Purpose: Prognostic uncertainty can be a barrier to providing palliative care. Accurate prognostic estimation for patients at the end of life is challenging. This study aimed to evaluate the accuracy of end-of-life diagnosis using our unique diagnostic method. Patients and Methods: A …

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Supplementary Material for: Objective response and progression free survival contribute to prolong overall survival in atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma.

Kazuto Tajiri, Kenichiro Tsukada, Yoshiharu Tokimitsu, Yuchi Motofuji et autres

Introduction: Atezolizumab plus bevacizumab (Atez/Bev) is a standard treatment for unresectable hepatocellular carcinoma (HCC) due to its good anti-tumor and survival prolongation effects. Post-progression survival (PPS) has been reported to be a great contributor in the treatment with tyrosine kinase inhibitors for …

Impact of Post-progression Survival on Outcomes of Lenvatinib Treatment for Unresectable Hepatocellular Carcinoma: A Systematic Review and Retrospective Cohort Study

Kazuto Tajiri, Yoshiharu Tokimitsu, Kengo Kawai, Yuchi Motofuji et autres

BACKGROUND/AIM: Lenvatinib is a tyrosine kinase inhibitor (TKI) more effective against hepatocellular carcinoma (HCC) than sorafenib, making lenvatinib a first-line treatment option for patients with unresectable HCC. In patients treated with sorafenib, post-progression survival (PPS) rather than progression-free survival (PFS) is essential …

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MO10-4 Novel non-invasive biomarkers for the detection of myelofibrosis in patients with myeloproliferative neoplasms

Takaaki Maekawa, Tomoyuki Yoshikawa, Miki Moriiwa, Aoi Hirata et autres

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Direct-acting antivirals for hepatitis C virus-infected patients with hepatocellular carcinoma

Kazuto Tajiri, Hiroyuki Ito, Kengo Kawai, Yoshiro Kashii et autres

BACKGROUND: Hepatocellular carcinoma (HCC) in hepatitis C virus (HCV)-infected patients has a high risk of recurrence. Although eradication of HCV is expected to reduce this risk, the risk in patients with a history of HCC may be high after treatment with direct-acting …

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Accurate Identification and Prognostication of End-of-Life State in Japan Using A Guideline-Based Diagnostic Method: A Diagnostic and Prognostic Study

Masahisa Arahata, Hidesaku Asakura, Eriko Morishita, Shinji Minami et autres

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Pulmonary Pleomorphic Carcinoma Mimicking Primary Sarcoma of the Neck: A Case Report and Literature Review

Daishi Ogawa, Masahisa Arahata, Masato Kuriyama, Shunji Shinagawa et autres

We describe our challenge in diagnosing an unusual and rapidly progressing case of pulmonary pleomorphic carcinoma (PPC)-a rare, poorly differentiated, or undifferentiated non-small-cell carcinoma that can metastasize locally or distantly and has a poor prognosis. Our patient was an elderly man with …

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Understanding the immunopathogenesis of COVID-19: Its implication for therapeutic strategy

Yukihiro Shimizu

and suppressing the progression to cytokine storm. Blocking the action of cytokines with dexamethasone or anti-interleukin-6 could have a pivotal role in treatment of those patients. Therapeutic strategy should therefore be based on viral kinetics and the immunopathology of COVID-19.

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Nadir lymphocytopenia as a risk factor of bloodstream infection during molecular targeting pharmacotherapy in multiple myeloma

Yukihiro Shimizu, Hiroaki Inoue, Shigeru Hishinuma, Masaru Shoji

OBJECTIVE: Molecular targeting pharmacotherapy (MTP) with proteasome inhibitors and immunomodulatory drugs has led to a remarkable improvement in the effectiveness of multiple myeloma (MM) therapy. However, the effect of MTP on the occurrence of infections in patients with MM remains unclear. We …