Mary Gardiner

Effect of Immunosuppression on the Immune Response to SARS-CoV-2 Infection and Vaccination

Emma J. Leacy, Jia Wei Teh, Aoife M. O’Rourke, Gareth Brady et autres

Immunosuppressive treatment in patients with rheumatic diseases can maintain disease remission but also increase risk of infection. Their response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is frequently blunted. In this study we evaluated the effect of immunosuppression exposure on …

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Sustained VWF-ADAMTS-13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction

Helen Fogarty, Soracha E. Ward, Liam Townsend, Ellie Karampini et autres

BACKGROUND: Prolonged recovery is common after acute SARS-CoV-2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown. VWF/ADAMTS-13 imbalance, dysregulated angiogenesis, and immunothrombosis are hallmarks of acute COVID-19. We hypothesized that VWF/ADAMTS-13 imbalance persists in convalescence together with endothelial cell …

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42 EXPLORING THE IMPACT OF AGE AND FRAILTY STATUS ON THE IMMUNE RESPONSE TO COVID-19 ILLNESS USING DETAILED IMMUNO-PHENOTYPING

Adam H. Dyer, Liam Townsend, Aifric Naughton, Rachel Kiersey et autres

Abstract Background Whilst age and frailty are independently associated with mortality in COVID-19 illness, the underlying immunological mechanisms explaining this remain unexplored. We aimed to explore the impact of age and frailty on the acute immune response to COVID-19 illness. Methods We …

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Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health

Liam Townsend, Adam H. Dyer, Aifric Naughton, Rachel Kiersey et autres

Objectives The immunological and inflammatory changes following acute COVID-19 are hugely variable. Persistent clinical symptoms following resolution of initial infection, termed long COVID , are also hugely variable, but association with immunological changes has not been described. We investigate changing immunological parameters …

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Longitudinal analysis of COVID-19 patients shows age-associated T cell changes independent of ongoing ill-health

Liam Townsend, Adam H. Dyer, Aifric Naughton, Rachel Kiersey et autres

Abstract The trajectory of immunological and inflammatory changes following acute COVID-19 infection are unclear. We investigate immunological changes in convalescent COVID-19 and interrogate their potential relationships with persistent symptoms, termed long COVID . We performed paired immunophenotyping at initial SARS-CoV-2 infection and …

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Use of quantitative polymerase chain reaction (qPCR) for the diagnosis and monitoring of CNS leukaemia

Yasar Mehmood Yousafzai, Linda M. Smith, Amanda M. Smith, Saeeda Bhatti et autres

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Current Approaches and Clinician Attitudes to the Use of Cerebrospinal Fluid Biomarkers in Diagnostic Evaluation of Dementia in Europe

Anne-Marie Miller, Mircea Balasa, Kaj Blennow, Mary Gardiner et autres

BACKGROUND: BIOMARKAPD seeks to diminish the barriers associated with the clinical use of cerebrospinal fluid (CSF) biomarker analysis by reducing variation in CSF laboratory methodologies and generating consensus recommendations on their clinical interpretation and application for dementia diagnosis. OBJECTIVE: To examine the …

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[P1–247]: DIAGNOSTIC UTILITY OF CEREBROSPINAL FLUID BIOMARKERS IN IRISH SUBJECTS WITH COGNITIVE IMPAIRMENT

Mircea Balasa, Anne‐Marie Miller, Sarah O’Dwyer, Siobhán Hutchinson et autres

CSF biomarkers have been recently implemented in Ireland for clinical use in subjects with cognitive impairment with several sites performing the CSF extraction and a single national reference laboratory carrying out the assay. To-date, there are no published data on their clinical …

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