W. Todd Abraham

Transcatheter edge-to-edge repair in secondary mitral regurgitation

Josep Rodés‐Cabau, Siddhartha Mengi, Erwan Salaün, Jean‐Michel Paradis et autres

Secondary mitral regurgitation (SMR) is frequent among patients with heart failure (HF) with reduced ejection fraction (HFrEF), and it is strongly associated with increased mortality, frequent hospitalisations, and poor quality of life. The mechanisms underlying SMR are multifactorial. While guideline-directed medical therapy …

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Assessing Medical Therapy Optimization in Cardiovascular-Kidney-Metabolic Clinical Trials

Ankeet S. Bhatt, Diana De Oliveira-Gomes, Mona Fiuzat, Muthiah Vaduganathan et autres

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Building the Iowa Data Drive: A Participatory Approach to Developing Early Childhood Indicators for State and Local Policymaking

Heather L. Rouse, Sharon Zanti, Hannah Kim, Cassandra Dorius et autres

Introduction: Public service leaders face increasing challenges using data effectively due to program silos, limited resources, and the increasing complexity of data. To address these challenges, Iowa's Integrated Data System for Decision-Making (I2D2) partnered with state and local leaders in early childhood …

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Timing of Cardiac Resynchronization Therapy Following Stable Medical Therapy in Patients With Heart Failure

Alessandro Villaschi, Christian Basile, Lina Benson, Paolo Gatti et autres

BACKGROUND: Guidelines' recommendations for cardiac resynchronization therapy (CRT) implantation in selected patients with heart failure (HF) exist. However, data on the best timing for CRT implantation after the achievement of stable medical therapy (SMT) and its association with outcomes are currently lacking. …

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Effect of Pulmonary Artery Pressure-Guided Management on Outcomes of Patients with Heart Failure Outside Clinical Trials: A Systematic Review and Meta-Analysis of Real-World Evidence with the CardioMEMS Heart Failure System

Chris J. Kapelios, Sotiria Liori, Michael Bonios, W. Todd Abraham et autres

AIMS: Pulmonary artery pressure (PAP)-guided heart failure (HF) management using the CardioMEMS HF System improves patient outcomes in randomized controlled trials (RCTs). Our aim was to systematically assess its impact on outcomes of HF patients receiving the device in a non-RCT setting. …

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Clinical phenotypes and outcomes associated with improved left ventricular ejection fraction after biventricular pacing

Sameer Kunte, Lurdes Y. T. Inoue, W. Todd Abraham, John G.F. Cleland et autres

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BARRIERS TO ENROLLMENT OF WOMEN IN HEART FAILURE CLINICAL TRIALS: INSIGHTS FROM THE HEART FAILURE COLLABORATORY

Christian Guilliod, Vanessa Blumer, Christopher M. O’Connor, W. Todd Abraham et autres

DEVELOPING A COMPREHENSIVE MEDICAL THERAPY SCORE FOR CARDIOVASCULAR-KIDNEY-METABOLIC SYNDROME: AN INITIATIVE FROM THE HEART FAILURE COLLABORATORY

Ankeet S. Bhatt, Carine Hamo, Mona Fiuzat, Muthiah Vaduganathan et autres

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Forward Flow in Patients With Heart Failure and Functional Mitral Regurgitation: The COAPT Trial

Zachary M. Gertz, Philippe Pibarot, Zhipeng Zhou, Michael Schonning et autres

Background Heart failure (HF) is characterized by a reduction in forward cardiac output (forward flow), potentially worsened by functional mitral regurgitation (FMR). The impact of reduced forward flow in HF patients with FMR is uncertain, and the outcomes of mitral transcatheter edge-to-edge …

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Impact of Baseline Anteroposterior Mitral Annular Dimensions on Clinical Outcomes after MitraClip for Secondary Mitral Regurgitation

Jason H. Rogers, Thomas W. Smith, Jeroen J. Bax, Federico M. Asch et autres

Background In the randomized Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation (COAPT; NCT01626079) trial, mitral transcatheter edge-to-edge repair (M-TEER) improved clinical outcomes in patients with severe secondary mitral regurgitation (MR). A prior post …

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Standardized Definitions of Changes in Kidney Function in Trials of Heart Failure

Anuradha Lala, Steven G. Coca, Jason Feinman, Carine Hamo et autres

Perturbations in kidney function are frequently encountered in heart failure (HF) across its spectrum in both chronic and acute settings with distinct implications for patient management and prognosis. Lack of consensus on the threshold for clinically meaningful changes in kidney function has …

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Barostim, NT-proBNP, And Clinical Outcomes In Heart Failure

JE Abraham, W. Todd Abraham, JoAnn Lindenfeld, Fred A. Weaver et autres

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