Meixia He

RkMsn4, a zinc finger transcription factor, regulates carotenoid and lipid metabolism to enhance tolerance to environmental stress in Rhodosporidium kratochvilovae

Meixia He, Mingjing Yang, Xinyan Xiong, 甘鈺瑄 et autres

ABSTRACT Red yeasts serve as indispensable microbial resources for the production of carotenoids and lipids; however, environmental stress factors often limit their performance during industrial fermentation. The zinc-finger transcription factors Msn2/Msn4 act as central regulators of stress responses in yeasts. However, researchers …

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Two-Step Cascade Process for Efficient Isolation of Cellulose from Sugarcane Trash

Jian Zhang, Jiang-Lin Yin, Liu-Yi Chen, Jie Gao et autres

Efficient and sustainable isolation of cellulose from sugarcane tops (ST), a major sub-fraction of sugarcane trash, is of great significance for the high-value valorization of cellulose and its subsequent conversion into substrates for biomaterials. This study introduces a novel two-step cascade process …

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Integrated transcriptomics and metabolomics analysis reveal the regulatory mechanisms underlying the combined effects of heat and glucose starvation on carotenoid biosynthesis in Rhodotorula glutinis YM25079

Xingyu Huang, Caina Guo, Xiaolan Huang, Meixia He et autres

Rhodotorula glutinis is an important oleaginous yeast that can synthesize various valuable compounds, including carotenoids, lipids, and exopolysaccharides. The effect of combined heat stress and glucose starvation on carotenoid biosynthesis in R. glutinis was investigated in this study. Carotenoid production in R. …

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Divergent roles of the acetyl-CoA synthetases RkACS1 and RkACS2 in carotenoid and lipid biosynthesis in Rhodosporidium kratochvilovae

Meixia He, Xiaoxia Yang, Chao Xiong, Yuxuan Gan et autres

Red yeasts demonstrate considerable potential in industrial and biotechnological applications, particularly in the biosynthesis of carotenoids and lipids, which are valuable secondary metabolites with a wide range of applications. In the oleaginous red yeast Rhodosporidium kratochvilovae YM25235, the acetyl-CoA synthetases RkACS1 and …

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Preparation of agarose microspheres with large pore size and high load and purification of antibody in serum based on microfluidic technology

Guanglei Chang, Miaomiao Yang, Zhaobin Xu, Xinling Wang et autres

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Comprehensive Response of Rhodosporidium kratochvilovae to Glucose Starvation: A Transcriptomics-Based Analysis

Meixia He, Rui Guo, Gongshui Chen, Chao Xiong et autres

Microorganisms adopt diverse mechanisms to adapt to fluctuations of nutrients. Glucose is the preferred carbon and energy source for yeast. Yeast cells have developed many strategies to protect themselves from the negative impact of glucose starvation. Studies have indicated a significant increase …

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The Noninvasive Sonothermogenetics Used for Neuromodulation in M1 Region of Mice Brain by Overexpression of TRPV1

Lulu Wang, Guanglei Chang, Miaomiao Yang, Zhaobin Xu et autres

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Mir-421 and mir-550a-1 are potential prognostic markers in esophageal adenocarcinoma

Yun Seong Ji, Lulu Wang, Guanglei Chang, Juan Yan et autres

OBJECTIVE: To identify the prognostic indicators of esophageal adenocarcinoma (EAC) for future EAC diagnosis and treatment. METHODS: The EAC dataset from The Cancer Genome Atlas was screened for differentially expressed microRNAs (miRNAs) and mRNAs associated with EAC. Weighted gene coexpression network analysis …

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Hybrid histidine kinase HisK2301 modulates carotenoid production to counteract cold-induced oxidative stress in Rhodosporidium kratochvilovae YM25235 under low temperature

Meixia He, Xiaoxia Yang, Tao Liu, Xiaoqing Zhang et autres

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Genome-Wide Transcriptional Changes of Rhodosporidium kratochvilovae at Low Temperature

Rui Guo, Meixia He, Xiaoqing Zhang, Xiuling Ji et autres

Rhodosporidium kratochvilovae strain YM25235 is a cold-adapted oleaginous yeast strain that can grow at 15°C. It is capable of producing polyunsaturated fatty acids. Here, we used the Nanopore Platform to first assemble the R. kratochvilovae strain YM25235 genome into a 23.71 Mb …

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Correction to “Suppression of Esophageal Squamous Cell Carcinoma Development by Mechanosensitive Protein Piezo1 Downregulation”

Lu Gao, Yun Seong Ji, Lulu Wang, Meixia He et autres

In the last line of Acknowledgments, the Grant No. YYYJK201803 in brackets is corrected to 2021BP0101.

Suppression of Esophageal Squamous Cell Carcinoma Development by Mechanosensitive Protein Piezo1 Downregulation

Lu Gao, Yun Seong Ji, Lulu Wang, Meixia He et autres

Esophageal squamous cell carcinoma (ESCC) is a malignant epithelial cancer of the esophageal epithelium. Piezo-type mechanosensitive ion channel component 1 (Piezo1), an essential mechanosensitive protein, plays an important role in maintaining cell biological functions under the stimulation of physiological force. Immunohistochemical and …

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