Ligang Zhou

Hemodynamic effects of finerenone on blood pressure and heart rate in hospitalized patients with type 2 diabetes: a real-world study

Song Wen, Dandan Yun, Yanju He, X I A O Li et autres

Background: While the long-term cardiorenal benefits of finerenone have been established in landmark clinical trials, its immediate impact on hemodynamic parameters in routine clinical practice remains to be fully characterized. This study aimed to evaluate the real-world acute effects of finerenone on …

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The Renal Micro-Vasculopathy and Systemic Aldosterone-Renin Ratio (ARR) in Type 2 Diabetic Patients—A Retrospective Real-World Study

Song Wen, Zhimin Xu, Min Gong, Congcong Wang et autres

Objective: To investigate whether the imbalanced aldosterone to renin ratio (ARR) is associated with renal micro-vasculopathy in type 2 diabetes mellitus (T2DM). Materials and Methods: Data from 471 T2DM patients were retrospectively analyzed from 2019 to 2023. Blood samples were collected for …

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Insulin Resistant States Contributed Differentially to the Earlier Renal tubular Injury in Chinese Young Overweight Individuals with Hyperglucagonemia

Yanhong Huang, Lijiao Chen, Wu Wang, Liang Zeng et autres

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The effects of non-insulin anti-diabetic medications on the diabetic microvascular complications: a systematic review and meta-analysis of randomized clinical trials

Song Wen, Yue Yuan, Yanyan Li, Chenglin Xu et autres

INTRODUCTION: Although the onset and progression of diabetic microvascular complications are linked to glycemic control, various antihyperglycemic drugs with distinct treatment targets may positively impact microvascular lesions beyond their glucose-lowering effects. Therefore, this systematic review emphasizes the clinical therapeutic implications of non-insulin …

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GDF15: An emerging disease target and biomarker of metabolic diseases

Chenyun Yang, Huiling Chen, Xiaojing Huang, Ligang Zhou et autres

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Factors influencing the initial glycemic efficacy of dorzagliatin, a novel glucokinase activator, in type 2 diabetes

Lijiao Chen, Jing Zhang, Song Wen, Ying Wang et autres

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Pilot Study of a Modified DOPS Scale for Insulin Pump and CGM Installation Training in Chinese Medical Students During Endocrinology Rotations

Yue Yuan, Congcong Wang, Song Wen, Yanyan Li et autres

Background: Direct Observation of Procedural Skills (DOPS) is a clinical assessment tool that enables trainers to observe medical students' procedural abilities in real-time clinical settings. It assesses students' knowledge application, decision-making, and skill proficiency during clinical tasks. Methods: This study modifies the …

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Sarcopenia in cirrhosis: From pathophysiology to interventional therapy

Chenyun Yang, Shijie Yan, Xintao Liu, Ligang Zhou et autres

Sarcopenia, characterized by the loss of skeletal muscle mass and function, is a significant complication in patients with cirrhosis. This condition not only exacerbates the overall morbidity and mortality associated with liver disease but also complicates patient management, increasing the risk of …

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The Implication of Elevated Serum Myoglobin Level in Acute Diabetic Complications of Ketoacidosis and Hyperglycemic Hyperosmolar State: A Real-World Study

Chenglin Xu, Song Wen, Min Gong, Meiyuan Dong et autres

Objective: To investigate the implications of elevated myoglobin (MYO) in acute diabetic conditions of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). Materials and methods: This study integrates in-patient data from Shanghai Pudong Hospital from 2019 to 2023. Laboratory data were compared …

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Utilize multi-metabolic parameters as determinants for prediction of skeletal muscle mass quality in elderly type2 diabetic Chinese patients

Huiling Chen, Jingjing Lou, Meiyuan Dong, Xintao Liu et autres

BACKGROUND: Sarcopenia, an age-related disorder characterized by loss of skeletal muscle mass and function, is recently recognized as a complication in elderly patients with type 2 diabetes mellitus (T2DM). Skeletal muscles play a crucial role in glycemic metabolism, utilizing around 80% of …

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Retinal microcirculation: A window into systemic circulation and metabolic disease

Yue Yuan, Meiyuan Dong, Song Wen, Xinlu Yuan et autres

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Utilize multi-metabolic parameters as determinants for prediction of skeletal muscle mass quality in elderly type2 diabetic Chinese patients

Jingjing Lou, Meiyuan Dong, Song Wen, Xintao Liu et autres

Abstract Background: Sarcopenia, an age-related disorder characterized by loss of skeletal muscle mass and function, is recently recognized as a complication in elderly patients with type 2 diabetes mellitus (T2DM). Skeletal muscles play a crucial role in glycemic metabolism, utilizing around 80% …

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