Chang Sup Lee

The Relationship Between Immunogenic Cell Death and Cellular Senescence in Cancer Immunotherapy

Seong-Ah Shin, Minji Kim, Moonsu Kim, Seyeon Choi et autres

Despite rapid advances in anticancer therapy, cancer incidence and mortality remain substantial worldwide. Although immune checkpoint inhibitors (ICIs), including anti-PD-1/PD-L1 and anti-CTLA-4 therapies, have transformed cancer treatment by harnessing host antitumor immunity, their efficacy remains limited to a subset of patients, largely …

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Immunogenic Cell Death Induced by EEO in Breast Cancer Cells Promotes Dendritic Cell Activation in a CRT-Dependent Manner

Seong-Ah Shin, Sun Young Moon, Seyeon Choi, Minji Kim et autres

Cancer immunotherapy faces significant challenges in treating “cold” tumors, which respond poorly to current strategies. Breast cancer is a major cause of cancer-related mortality in women and is a representative immunosuppressive cold tumor. The luminal A subtype of breast cancer exhibits an …

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Evaluation of plant-expressed human PD-1 as an immunogen capable of inducing native PD-1 recognizing antibodies

Hong Ju Moon, Gyeongik Ahn, Seong-Ah Shin, Chang Sup Lee et autres

Abstract Programmed cell death protein-1 (PD-1) is a key immune checkpoint receptor and an important target for therapeutic antibody development. A critical factor in the development of therapeutic monoclonal antibodies is the selection and preparation of the target antigen. Here, we established …

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Ethyl-2-oxo-2H-chromene-3-carboxylate exhibits anti-allergic effects by inhibiting IgE-mediated mast cell activation and passive cutaneous anaphylaxis in mice

Serim Lee, Moonsu Kim, Seong-Ah Shin, Sun Young Moon et autres

Abstract An allergy is an exaggerated immune response to an otherwise harmless substance. These reactions are triggered largely by mast cell activation and the subsequent release of inflammatory mediators. Although current allergy therapies effectively relieve symptoms, they are generally accompanied by side …

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Anti-cancer effects of wistin on malignant melanoma cells

Minjoo Han, Seong-Ah Shin, Huiji Kim, Mi‐Jeong Ahn et autres

Abstract Malignant melanoma (MM) is a severe skin cancer that arises from melanocytes, primarily caused by exposure to ultraviolet radiation. Although MM occurs less frequently than other skin cancers, its metastasis is easily activated, leading to a high mortality rate. MM incidence …

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Anti-allergic effect of 5,7-dihydroxy-4-methylcoumarin in IgE-mediated RBL-2H3 cells and PCA murine model

Sugeun Gwon, Seong-Ah Shin, Moonsu Kim, Sun Young Moon et autres

Abstract Allergy is an immune-mediated disorder characterized by an exaggerated response of the immune system to non-hazardous substances, resulting in allergic symptoms such as rash, itching, and runny nose. Current therapeutic interventions include antihistamines and steroids; however, they induce several side effects. …

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3-bromo-4-(2-hydroxyethyl)-7-methoxy-2H-chromen-2-one inhibits allergic reactions in IgE-mediated RBL-2H3 cells and a passive cutaneous anaphylaxis mouse model

Moonsu Kim, Huiji Kim, Sun Young Moon, Seong-Ah Shin et autres

Abstract Allergic reactions occur when the immune system overreacts to generally harmless substances, leading to both acute and chronic diseases, which can be fatal. Mast cells are critical mediators of allergic reactions as they bind allergens and trigger the release of inflammatory …

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Structural analysis of a bacterial ankyrin-like protein secreted by Acinetobacter baumannii

Ji Hye Sung, So Yeon Lee, Chang Sup Lee, Jun Hyuck Lee et autres

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Short Caco-2 model for evaluation of drug permeability: A sodium valerate-assisted approach

Naveed ur Rehman, Seong-Ah Shin, Chang Sup Lee, Miyoung Song et autres

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Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages

Min‐Ji Kim, Jangeun An, Seong-Ah Shin, Sun Young Moon et autres

Abstract Inflammation is an essential defense mechanism in health; however, excessive inflammation contributes to the pathophysiology of several chronic diseases. Although anti-inflammatory drugs are essential for controlling inflammation, they have several side effects. Recent findings suggest that naturally derived compounds possess physiological …

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An Improved In Vitro Blood-Brain Barrier Model for the Evaluation of Drug Permeability Using Transwell with Shear Stress

Jun-Hyeong Kim, Seong-Ah Shin, Chang Sup Lee, Hye Jin Chung

The development of drugs targeting the central nervous system (CNS) is challenging because of the presence of the Blood-Brain barrier (BBB). Developing physiologically relevant in vitro BBB models for evaluating drug permeability and predicting the activity of drug candidates is crucial. The …

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DB3 from Antarctic lichen inhibits the growth of B16F10 melanoma cells in vitro and in vivo

Seyeon Choi, Huiji Kim, Seong-Ah Shin, Moonsu Kim et autres

Abstract Malignant melanoma is a fatal disease with an increasing global incidence. Despite numerous studies focused on anti-cancer drugs, a variety of side effects of cancer treatment remain challenging. Thus, there is a pressing need to identify novel anti-cancer agents with minimal …

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