Tomohiro Murata

Real-world use of dotinurad and one-year prescription presence by kidney function in older adults

Ryosuke Saiki, Masaki Tanabe, Tomohiro Murata, Daisuke Yamasaki et autres

Evidence on dotinurad, a selective urate transporter 1 inhibitor, in older adults with reduced kidney function is limited. We conducted a retrospective cohort study using the Japan Medical Data Center elderly claims database from April 2021 to February 2023 to describe real-world …

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295 Keratinocytes Expressing KID Syndrome Mutation Fuel Chronic Candida Infection via Impaired Candida Sensing and Chemokine Production

Alshimaa Mostafa, Tomohiro Murata, Akihiko Kitoh, Kenji Kabashima

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Dotinurad, a Novel Urate Reabsorption Inhibitor, Prolongs Survival in Alport Mice

Ryosuke Saiki, Kan Katayama, Mutsuki Mori, Lupiya Kimena et autres

Key Points Dotinurad treatment slows the progression of kidney disease in a mouse model of Alport syndrome, a genetic model of CKD. Dotinurad may represent a potential therapeutic strategy for CKD management. Background Hyperuricemia contributes to inflammatory conditions such as gout and …

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Coronavirus Disease 2019-associated Minimal Change Disease: Transient Improvement Does Not Preclude the Need for Standard Therapy in a Case Report and Review of the Literature

Ryunosuke Saiki, Kan Katayama, Enyo Akiyama, Tomohiro Murata et autres

Minimal change disease can be associated with coronavirus disease 2019 (COVID-19). We herein report a 38-year-old woman who developed biopsy-proven minimal change disease 5 days after COVID-19 infection. Initial observation showed some spontaneous reduction in proteinuria, which later worsened. Treatment with low-dose …

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Debranching Thoracic Endovascular Aortic Repair (TEVAR) for Thoracoabdominal Aortic Dissecting Aneurysm Involving the Visceral Arteries: A Case Report

Naoto Miyagi, Aiko Hirayama, Tomohiro Murata, Ryosuke Amitani et autres

Surgical repair of thoracoabdominal aortic aneurysms (TAAA) is a complex procedure that is associated with marked morbidity and mortality. Endovascular TAAA repair, initially reserved for patients at high risk, has yielded promising results and is performed on an increasing range of patients. …

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Latent Tubulointerstitial Nephritis with IgM-positive Plasma Cells Uncovered in a Case of IgA Nephropathy and Primary Biliary Cholangitis: Clinical and Histological Insights

Ryosuke Saiki, Kan Katayama, Enyo Akiyama, Keiko Oda et autres

Patients with anti-mitochondrial antibody positivity rarely develop tubulointerstitial nephritis with IgM-positive plasma cells (IgMPC-TIN). A previous report observed elevated serum IgM and urinary β2 microglobulin levels in all cases of IgMPC-TIN. This case involved IgA nephropathy with latent coexisting IgMPC-TIN; however, no …

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Pneumonia-Masked Pulmonary Embolism in Nephrotic Syndrome: Diagnostic Value of V/Q Scintigraphy: A Case Report

Ryunosuke Saiki, Kan Katayama, Tomohiro Murata, Kaoru Dohi

Background and Clinical Significance: Nephrotic syndrome predisposes patients to venous thromboembolism. This case highlights the challenges of diagnosing pulmonary embolism in nephrotic syndrome patients with renal dysfunction, and emphasizes the utility of ventilation–perfusion lung scintigraphy when the contrast is contraindicated. Case Presentation: …

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Correction to: A case of acute kidney injury and Fanconi syndrome while taking multiple supplements, including Red Yeast Rice Cholesterol Help®

Keiko Oda, Tomohiro Murata, Fumika Tanaka, Hidemasa Oda et autres

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A case of acute kidney injury and Fanconi syndrome while taking multiple supplements, including Red Yeast Rice Cholesterol Help®

Keiko Oda, Tomohiro Murata, Fumika Tanaka, Hidemasa Oda et autres

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The Protective Role of KANK1 in Podocyte Injury

Keiko Oda, Kan Katayama, Liqing Zang, Masaaki Toda et autres

Approximately 30% of steroid-resistant nephrotic syndromes are attributed to monogenic disorders that involve 27 genes. Mutations in KANK family members have also been linked to nephrotic syndrome; however, the precise mechanism remains elusive. To investigate this, podocyte-specific Kank1 knockout mice were generated …

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The Protective Role of KANK1 in Podocyte Injury

Keiko Oda, Kan Katayama, Liqing Zang, Masaaki Toda et autres

Approximately 30% of steroid-resistant nephrotic syndromes are attributed to monogenic disorders that involve 27 genes. Mutations in KANK family members have also been linked to nephrotic syndrome; however, the precise mechanism remains elusive. To investigate this, podocyte-specific Kank1 knockout mice were generated …

jp, se (code pays fourni par la source)

Safety and outcomes of surgical treatment of atrial fibrillation in emergency surgery cases

Shun‐ichiro Sakamoto, Tomohiro Murata, Motohiro Maeda, Atsushi Hiromoto et autres

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